Publications (2)2.53 Total impact
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Article: [Instent restenosis related to vessel injury score degree. Are current experimental models valid for drug-eluting stents analysis?].
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ABSTRACT: Drug-eluting stents are useful for preventing restenosis, but the patho-physiological processes involved in the proliferative response after implantation are still not known in detail. The aim of this study is to compare the coronary vascular histomorphometry after implanting drug-eluting stents and bare metal stents in a swine model. Sixty stents were randomly implanted in 20 Large White female pigs with a ratio of baremetal/drug-eluting stents of 1:2. After 28 days, euthanasia and histomorphometry were performed. We defined the vessel injury score in accordance to whether the internal elastic lamina was intact or ruptured. There were no differences between drug-eluting stents and bare metal stents in the intact internal elastic lamina group regarding neointimal area or % restenosis (1.3 [1.1-2.2]) vs 2.0 [1.3-2.5] mm²; P=.6; and 14.0 [12.1-20.8] vs 22.2 [14.1-23.3] %; P=.5). We assessed statistically significant differences for the ruptured internal elastic lamina group, (neointimal area 1.2 [0.8-2.0] vs 2.9 [2.3-3.7] mm²; P=.001 and % restenosis 16.63 [11.2-23.5] vs 30.4 [26.4-45.7] %; P=.001). In our swine model, we did not find any differences between proliferative response of drug-eluting stents and bare metal stents when the internal elastic lamina is intact; differences are only found when vascular injury is deeper.Revista Espa de Cardiologia 06/2011; 64(9):745-51. · 2.53 Impact Factor -
Article: A jaw model for the study of the mandibular flexure taking into account the anisotropy of the bone
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ABSTRACT: Knowledge of the complex biomechanical behaviour of the human mandible is of great importance in various clinical situations. The biomechanical and physical behaviour of mandibles have been investigated by different approaches. Some research have been done to evaluate the functional character of mandibles. Methods such as indirect measurement of deformations performed by intraoral appliances and by holographic interferometry have being employed. Other studies evaluated the mechanical properties and material parameters of small cubes of mandibles. One disadvantage of the experiments using strain gauges or holographic interferometry is the inability to determine strains at defined positions within the specimen. Additionally, research in biomechanics by these methods is limited to surface deformations and neither stresses nor dislocations can be measured.In the course of this study, we have investigated the mandibular flexure under mechanical loads using the results of a Finite Element Analysis (FEA). In order to obtain more accurate and realistic results, the bone anisotropy has being taken into account for the mathematical modelling of the jaw.The objective of this study was to establish a non-invasive procedure to predict precisely the complex biomechanical reactions of mandibles under mechanical loading. In order to achieve this aim, a comparison of the numerical data obtained with the experimental values of previous studies was performed. It showed a good correlation between in vitro measurements and mathematical modelling. Then the Finite Elements (FE) model was used to evaluate some mandibular movements (corporal approximation, dorsoventral shear, and corporal rotation in edentulous subjects).It is concluded that the applied procedure of generating the FE model is a valid and accurate non-invasive method to predict different parameters of the complex biomechanical behaviour of human mandibles.Mathematical and Computer Modelling.
