Yanpeng Xu

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Publications (2)5.3 Total impact

  • Article: Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides.
    Xiaozhuo Chen, Peng Xu, Yanpeng Xu, Lu Liu, Yi Liu, Di Zhu, Pingsheng Lei
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    ABSTRACT: A series of novel modified 5-O-desosamine-ketolides were synthesized. The 5-O-desosamine fragment was removed from ketolide by an efficient and mild manipulation. 4-O-substituted desosamine was introduced into the ketolide aglycon and various coupling methods were essayed for the glycosylation. Three novel ketolides were tested for in vitro antibacterial activity against a panel of susceptible and resistant pathogens. Compound 26 showed potent activity against all the methicillin-sensitivity and resistant pathogens.
    Bioorganic & medicinal chemistry letters 10/2012; · 2.65 Impact Factor
  • Article: Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities.
    Dan Zheng, Yuyao Guan, Xiaozhuo Chen, Yanpeng Xu, Xiaoguang Chen, Pingsheng Lei
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    ABSTRACT: To fulfill the structure-activity relationship (SAR) of OSW-1, and aim at finding the simplest structural part while maintaining most of the biological activities, six cholestane saponins were synthesized by introducing OSW-1 disaccharide (2-O-4-methoxybenzoyl-β-D-xylopyranosyl-(1→3)-2-O-acetyl-α-L-arabinopyranosyl) and its 1→4-linked analogue to the 7-hydroxy or 16-hydroxy of steroidal sapogenins. Cytotoxic activities of the products were tested. Compounds 1 and 3 exhibited potent cytotoxicities against five types of human tumor cells, with minimum IC(50) of 2.0 and 75 nM, respectively. And due to its high activity and easy accessibility compound 1 could be a potential candidate for new anti-tumor agents.
    Bioorganic & medicinal chemistry letters 06/2011; 21(11):3257-60. · 2.65 Impact Factor
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