Yu-Hong Qi

Fourth Military Medical University, Xi’an, Liaoning, China

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Publications (3)4.82 Total impact

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    ABSTRACT: Several studies have indicated an association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and the risk of hepatocellular carcinoma (HCC). However, the conclusions are inconsistent. Therefore, a meta-analysis was performed. Databases like Pubmed, EMBASE, and EBSCO (up to September 2012) were searched to retrieve case-control trials about MTHFR (C677T or A1298C) polymorphisms and HCC. Literatures were independently screened by two researchers according to the inclusion and exclusion criteria. Data were extracted and analyzed by software STATA 11.0. Nine studies were included with 10 datasets and 5132 cases. C677T polymorphism was associated with HCC risk in a heterozygous model (TT vs. CT: OR=1.20, 95% CI: 1.02-1.40). For the A1298C polymorphism, a significantly decreased HCC risk was found in the dominant, heterozygous and homozygous models (CC vs. AA+AC: OR=0.52, 95% CI: 0.33-0.80; CC vs. AC: OR=0.50, 95% CI: 0.32-0.79; CC vs. AA: OR=0.52, 95% CI: 0.33-0.81). Subgroup analysis stratified by ethnicity and type of control further indicated decreased HCC risks in Asians (CC vs. AA+AC: OR=0.47, 95% CI: 0.26-0.84; CC vs. AC: OR=0.41, 95% CI: 0.24-0.71; CC vs. AA: OR=0.46, 95% CI: 0.27-0.78), studies with controls of healthy people (CC vs. AA: OR=0.54, 95% CI: 0.31-0.93; CC vs. AC: OR=0.54, 95% CI: 0.31-0.94; CC vs. AA+AC: OR=0.55, 95% CI: 0.32-0.94), and controls of non-HCC patients (CC vs. AC: OR=0.43, 95% CI: 0.19-0.96). Homozygous carriers of MTHFR C677T mutation are more susceptible to HCC, but homozygous mutations of MTHFR A1298C may play a protective role for developing HCC.
    Gastroentérologie Clinique et Biologique 12/2013; · 0.80 Impact Factor
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    ABSTRACT: Previously we found that exposure to electromagnetic pulse (EMP) induced an increase in blood-brain-barrier (BBB) permeability and the degradation of tight junction protein ZO-1 in rats. Matrix metalloproteinases (MMPs), in particular gelatinases (MMP-2 and MMP-9), play a key role in degradation of tight junction proteins, are known mediators of BBB compromise. We hypothesized that the degradation of ZO-1 by gelatinases contributed to EMP-induced BBB opening. To test this hypothesis, the mRNA level of ZO-1, protein levels of MMP-2, MMP-9 and tissue inhibitor of metalloproteinases (TIMP-1 and TIMP-2) were detected in rat cerebral cortex after exposing rats to EMP at 200 kV/m for 200 pulses. It was found that the mRNA level of ZO-1 was unaltered at different time points after EMP exposure. The protein levels of MMP-2 and MMP-9 significantly increased at 3 h and 0.5 h, respectively. However, TIMP-1 (inhibitor of MMP-9) and TIMP-2 (inhibitor of MMP-2) only moderately increased after EMP exposure. In addition, in situ zymography results showed that the gelatinase activity increased in cerebral microvessels at 3 h after EMP exposure. When rats were treated with gelatinases inhibitor (SB-3CT) before EMP exposure, the EMP-induced BBB opening was attenuated and the ZO-1 degradation was reversed. Our results suggested that EMP-induced BBB opening was related to gelatinase mediated ZO-1 degradation.
    Toxicology 07/2011; 285(1-2):31-8. · 4.02 Impact Factor
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    ABSTRACT: AIM: The present paper investigated the effect on open-field behavior of male rat 3 months after electromagnetic pulse irradiation. MATERIALS AND RESULTS: Mature male rats were randomly divided into control group, 100P irradiation group and 1000P irradiation group. Rats in the EMP irradiation group were exposed to EMP. The field intensity was 100KV/m with 100 pulses and 100KV/m with 1000 pulses. The changes of behavior were observed with open-field test in rats 3 months after electromagnetic pulse irradiation. Accumulative Distance (AD), Accumulative Time (AT), AD of Walking, AT of Walking, AD of Resting, AT of Resting were recorded. Analysis of open-field test indicated that the activity of the EMP irradiation group has a significant decrease compared with control group (P<0.05), And it was also indicated that there are no significantly difference between 100P irradiation group and 1000P irradiation group. CONCLUSION: It is inferred that Electromagnetic pulse irradiation can cause some disorders of behavior of rats, which may induce a significant decrease in the activity in rats 3 months after EMP irradiation.
    12/2007: pages 473-475;

Publication Stats

7 Citations
4.82 Total Impact Points

Institutions

  • 2013
    • Fourth Military Medical University
      • Department of Radiology
      Xi’an, Liaoning, China