ABSTRACT: The aim of the present study was to evaluate the prevalence of abnormal Pap smears as detected by liquid-based (LBP) and conventional (CPP) techniques in women who were patients in the gynecologic clinic, Thammasat University Hospital.
Retrospective analysis of cervical cancer screening, histopathological findings and operative procedures was done between January 2009 and December 2009. Of the 6,332 participants who underwent gynecological examination and cervical screening and had a Pap smear result as atypical squamous cells of undetermined significance or worse would be performed a further colposcopic examination.
A total of 6,332 women were screened for cervical cancer in the one year period. A total of 169 abnormal Pap smears were found. Of 497 (8%) and 5,835 (92%) women were screened by LBP and CPP, respectively. The mean age of patients was 39.45 years old (14-90) and 1,550 (24.5%) women were post menopausal. The Prevalence of abnormal Pap smears was 4.0 and 2.6% in the LBP and CPP groups, respectively. Among LBP group, patients with atypical smear and LSIL (low grade squamous intraepithelial lesion) were 11 (2.29%) and 9 (1.8%), respectively. While CPP group, patient with atypical smear, LSIL, HSIL (high grade squamous intraepithelial lesion) and cancer were 73 (1.25%), 49 (0.84%), 25 (0.43%) and 2 (0.03%), respectively.
The prevalence of abnormal Pap smear in women who attended gynecologic clinic of Thammasat University Hospital was 4.0% and 2.6 % per LBP and CPP group, respectively. There was no significant difference in the incidence of atypical smear and false positive result between LBP and CPP.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet 12/2011; 94 Suppl 7:S47-51.
ABSTRACT: A case of well differentiated endometriod adenocarcinoma of the endometrium with a synchronous endometriod and clear cell adenocarcinoma of both ovaries was reported. Recently, a 28-year-old woman presented with vaginal bleeding was diagnosed to have only FIGO stage IaG1 (FIGO 2000) cancer of the endometrium. After 3 months of high dose progestin treatment, 15 cm bilateral ovarian tumors later diagnosed as FIGO stage IIIa ovarian cancer (mixed endometriod and clear cell adenocarcinoma) were detected, and later surgically removed. The patient then was started on Placitaxel/Carboplatin combination chemotherapy for 6 cycles after surgery. The synchronous cancers of endometrium and ovary are usually presented in woman with median age of 50 with obesity, diabetes, and hypertension. These low grade tumors and better prognosis are the norm in contrast to the authors' case with clear cell component and higher stage of ovarian cancer in young lean Thai woman.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet 12/2011; 94 Suppl 7:S208-13.
ABSTRACT: To determine the prevalence of abnormal cervical cytology by liquid based cytology (LBC) in pregnant women who attended the antenatal care clinic at Thammasat University Hospital.
LBC was performed on specimens from the collecting vial containing preserved cell solution (Cytyc, Boxborough, MA) in pregnant women who attended antenatal care at the antenatal care clinic, Thammasat University Hospital between March and July 2010. One hundred forty three pregnant women were recruited in the present study. All cytological reports were reviewed by senior cytopathologists for accurate diagnosis using the Bethesda System 2001 criteria. Patients with abnormal results as "abnormal squamous/glandular cells of undetermined significant" or more over were referred for colposcopic examination.
One hundred forty three pregnant women participated in the present study. The average age was 27.09 years. There were 10 abnormal Pap smear results with four, five, and one cases of ASC-US, LSIL and HSIL respectively The prevalence of abnormal cervical cytology in this investigation was 7% with 0.7% high-grade cervical intraepithelial neoplacia. Only 6% of participants had the correct understanding of the necessity of Pap smear testing. Thirty-one percent of multiparous pregnant women in the present study had no previous Pap smear screening. The majority of participants had coitarche before the age of 20.
The prevalence of abnormal cervical cytology in pregnant patients attending the antenatal care clinic at Thammasat University Hospital was 7%. The cervical cytology and related education were highly recommended in antenatal care clinic to increase cervical cancer screening coverage among reproductive age women.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet 02/2011; 94(2):152-8.