Takahiro Hatsuse

Nagaoka University of Technology, Nagaoka, Niigata-ken, Japan

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Publications (2)1.52 Total impact

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    ABSTRACT: Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by human T-cell lymphotropic virus type I (HTLV-1). Clinical manifestations of ATL range from smoldering to chronic, lymphoma and acute subtypes. Patients with acute and lymphoma-type ATL require therapeutic intervention. Conventional chemotherapeutic regimens used against other malignant lymphoma have been administered to ATL patients, but the therapeutic outcomes of acute and lymphoma-type ATL remain very poor. In this study, 214 extracts from 162 plants belonging to 65 families were screened for the purpose of elucidating the anti-proliferative effect against HTLV-1-infected T-cell lines. Extracts from aerial parts of Physalis pruinosa showed potent inhibitory effect. We isolated five withanolides from the extracts by activity-guided fractionation and examined the structure-activity relationships. The presence of a 5β,6β-epoxy function is suggested to be essential for the activity, and the most active principle showed selective toxicity to HTLV-1-infected T-cell lines.
    Journal of Natural Medicines 07/2011; 65(3-4):559-67. · 1.52 Impact Factor
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    ABSTRACT: Copper-doped hydronium alunite ((H3O)Al3(SO4)2(OH)6:Cu) was synthesized under hydrothermal conditions (240 °C, 60 min) from copper nitrate and aluminium nitrate solutions mixed with elemental sulfur. SEM and XRD measurements revealed that pseudocubic crystals of hydronium alunite and a small amount of boehmite rods coexisted in the resultant product. XPS measurements revealed the presence of monovalent copper (Cu+). Blue cathodoluminescence and photoluminescence were observed at about 414 and 419 nm, respectively. Two photoluminescence excitation bands were found at 295 and 325 nm. The excitation and emission processes for photoluminescence may involve the 3d103d94s1 transition of the Cu+ ion. (H3O)Al3(SO4)2(OH)6:Cu has the potential to be used as a blue luminescent phosphor for both electron beam and ultraviolet irradiation.
    IOP Conference Series Materials Science and Engineering 04/2011; 21(1):012004.