Tao Jiang

East China University of Science and Technology, Shanghai, Shanghai Shi, China

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Publications (8)32.62 Total impact

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    ABSTRACT: A dual-drug-loaded micelle is designed and constructed from a mixture of poly(propylene oxide)-b-poly(γ-benzyl-l-glutamate)-b-poly(ethylene glycol) (PPO-b-PBLG-b-PEG) triblock terpolymers and two model drugs, doxorubicin (DOX) and naproxen (Nap). In the micelles, the DOX is chemically linked to the PBLG backbones through an acid-cleavable hydrazone bond, whereas the Nap is physically encapsulated in the cores. The drug loading and releasing behaviors of the dual-drug-loaded micelles as well as single drug-loaded micelles (DOX-conjugated or Nap-loaded micelles) are studied. The structures of micelles are characterized by means of microscopies and dynamic light scattering, and further examined by dissipative particle dynamics (DPD) simulations. It is revealed that the micelles possess a core–shell–corona structure in which the PPO/Nap, PBLG/DOX, and PEG aggregate to form the core, shell, and corona, respectively. In vitro studies reveal that the release of DOX and Nap is pH- and thermosensitive. Such drug releasing behaviors are also examined by DPD simulations, and more information regarding the mechanism is obtained. In addition, the bio-related properties such as cellular uptake of the micelles and biocompatibility of the deliveries are evaluated. The results show that the dual-drug-loaded micelles are biocompatible at normal physiological conditions and retain the anti-cancer efficiency.
    Journal of Interconnection Networks 03/2014;
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    ABSTRACT: Phase behaviors of supramolecular graft copolymers with reversible bonding interactions were examined by the random-phase approximation and real-space implemented self-consistent field theory. The studied supramolecular graft copolymers consist of two different types of mutually incompatible yet reactive homopolymers, where one homopolymer (backbone) possesses multifunctional groups that allow second homopolymers (grafts) to be placed on. The calculations carried out show that the bonding strength exerts a pronounced effect on the phase behaviors of supramolecular graft copolymers. The length ratio of backbone to graft and the positions of functional groups along the backbone are also of importance to determine the phase behaviors. Phase diagrams were constructed at high bonding strength to illustrate this architectural dependence. It was found that the excess unbounded homopolymers swell the phase domains and shift the phase boundaries. The results were finally compared with the available experimental observations, and a well agreement is shown. The present work could, in principle, provide a general understanding of the phase behaviors of supramolecular graft copolymers with reversible bonding.
    The Journal of Chemical Physics 11/2013; 139(18):184901. · 3.16 Impact Factor
  • Tao Jiang, Liquan Wang, Jiaping Lin
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    ABSTRACT: In present work, we designed a multicompartment gel by taking advantages of ABC graft copolymer with solvophilic A backbone and solvophobic B, C grafts. The mechanical properties of such designed gels were investigated by a combination of dissipative particle dynamics simulation and nonequilibrium deformation technique. The extensional moduli of multicompartment gels were found to be dependent on polymer concentration and architecture parameters of graft copolymers (the sequence of graft arms and the position of graft points). The graft copolymer solutions undergo a sol-gel transition as the polymer concentration increases. This leads to an abrupt increase in extensional modulus. The studies also revealed that the multicompartment gels of graft copolymers exhibit higher extensional moduli than non-multicompartment gels of graft copolymers and triblock copolymer gels. The position of graft points plays another important role in determining the extensional moduli of the multicompartment gels. The effects of graft positions on gel modulus were found to be associated with the bridging fraction of graft copolymer chains. The results gained through the present work may provide useful guide for designing high-performance gels.
    Langmuir 09/2013; · 4.19 Impact Factor
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    ABSTRACT: As you like it: The synthesis of supramolecular hierarchical nanostructures with designed morphologies has been realized through computer-simulation-guided multicomponent assembly of polypeptide-based block copolymers and homopolymers. By adjusting the attraction between hydrophobic polypeptide rods, as well as other parameters such as molar ratio of copolymers and the rigidity of polymers, a variety of morphologies were obtained.
    Angewandte Chemie International Edition 06/2013; · 13.73 Impact Factor
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    ABSTRACT: Self-assembly of mixture systems containing poly(acrylic acid)-g-poly(γ-benzyl-L-glutamate) graft copolymers (PAA-g-PBLG) and PBLG homopolymers in aqueous solution was investigated by both experiments and computer simulations. It was found that the aggregate morphologies, such as rods, curved rods, and toroids could be tuned by the homopolymer content. The toroidal micelles with uniform size were formed when the homopolymer content in the hybrid aggregates is higher. The effect of added water content on the toroid formation process was studied. Rods and curved rods were observed sequentially before the formation of toroids. We also performed dissipative particle dynamics (DPD) simulations to verify the structure transition and explore the formation mechanism of the toroidal aggregates. The DPD results are in good agreement with the experimental findings and provide additional information such as chain distribution in aggregates which is difficult to be gained through experiments. On the basis of the experimental and simulation results, the formation mechanism of the toroidal micelles was suggested.
    Langmuir 06/2013; · 4.19 Impact Factor
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    ABSTRACT: Self-assembly behavior of rod-coil-rod poly(γ-benzyl-L-glutamate)-b-poly(ethylene glycol)-b-poly(γ-benzyl-L-glutamate) (PBLG-b-PEG-b-PBLG) triblock copolymers with various PBLG block lengths in aqueous solution was investigated. The PBLG-b-PEG-b-PBLG triblock copolymers are able to self-assemble into vesicles when PBLG block length is relatively short. Meanwhile, the initial polymer concentration was found to have influence on the self-assembly. Giant vesicles can be observed when the initial concentration is high. Dissipative particle dynamics (DPD) simulations about the vesicles revealed that the rigid rod blocks could be aligned parallelly with each other to form the monolayer vesicles wall. When the PBLG block length in the PBLG-b-PEG-b-PBLG triblock copolymers increases, the aggregate morphologies were observed to transform from vesicles to spherical micelles. Based on the experimental and simulation results, we proposed a possible mechanism of the morphological transitions of the rod-coil-rod triblock copolymer aggregates.
    Polymer. 01/2013;
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    ABSTRACT: The self-assembly behavior of ABA coil-rod-coil triblock copolymers in a selective solvent was studied by a Brownian molecular dynamics simulation method. It was found that the rod midblock plays an important role in the self-assembly of the copolymers. With a decrease in the segregation strength, ɛ(RR), of rod pairs, the aggregate structure first varies from a smecticlike disk shape to a long twisted string micelle and then to small aggregates. The influence of the block length and the asymmetry of the triblock copolymer on the phase behavior were studied and the corresponding phase diagrams were mapped. It was revealed that the variation of these parameters has a profound effect on microstructure. The simulation results are consistent with experimental results. Compared to rod-coil diblock copolymers, the coil-rod-coil triblock copolymers has a larger entropy penalty associated with the interfacial grafting density of the aggregate, leading to a higher ɛ(RR) value for structural transitions.
    The Journal of Chemical Physics 07/2011; 135(1):014102. · 3.16 Impact Factor
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    ABSTRACT: Using dissipative particle dynamics simulation, structural evolution from concentric multicompartment micelles to raspberry-like multicompartment micelles self-assembled from linear ABC triblock copolymers in selective solvents was investigated. The structural transformation from concentric micelles to raspberry-like micelles can be controlled by changing either the length of B blocks or the solubility of B block. It was found that the structures with B bumps on C surface (B-bump-C) are formed at shorter B block length and the structures with C bumps on B surface (C-bump-B) are formed at relative lower solubility of B blocks. The formation of B-bump-C is entropy-driven, while the formation of C-bump-B is enthalpy-dominated. Furthermore, when the length of C blocks is much lower than that of B blocks, an inner-penetrating vesicle was discovered. The results gained through the simulations provide an insight into the mechanism behind the formation of raspberry-like micelles.
    Langmuir 05/2011; 27(10):6440-8. · 4.19 Impact Factor