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Journal of the American Academy of Dermatology 06/2012; 66(6):e242-3. · 3.99 Impact Factor
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ABSTRACT: Actinic cheilitis (AC), a common disorder of the lower lip, should be treated early to prevent progression to invasive squamous cell carcinoma. This study evaluated the safety and efficacy of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) activated by blue light for the treatment of AC. Fifteen patients with clinically evident or biopsy-proven AC received two treatments with ALA PDT with blue light activation. Treatments were spaced three to five weeks apart. Most patients achieved 65% to 75% clearance three to five weeks after the first treatment and all achieved more than 75% clearance one month after the second treatment. Three patients achieved complete clearance. Pain and burning during irradiation were absent or mild. All patients said they would repeat the procedure. ALA PDT with 417 nm blue light is a promising option for the treatment of AC of the lower lip.
Journal of drugs in dermatology: JDD 11/2011; 10(11):1240-5. · 1.57 Impact Factor
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Archives of dermatology 09/2011; 147(9):1117-8. · 4.76 Impact Factor
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ABSTRACT: The dermatoscopic examination of the nail plate has been recently introduced for the evaluation of pigmented nail lesions. There is, however, no evidence that this technique improves diagnostic accuracy of in situ melanoma.
To establish and validate patterns for intraoperative dermatoscopy of the nail matrix.
Intraoperative nail matrix dermatoscopy was performed in 100 consecutive bands of longitudinal melanonychia that were excised and submitted to histopathologic examination.
We identified 4 dermatoscopic patterns: regular gray pattern (hypermelanosis), regular brown pattern (benign melanocytic hyperplasia), regular brown pattern with globules or blotch (melanocytic nevi), and irregular pattern (melanoma).
Nail matrix dermatoscopy is an invasive procedure that can not routinely be performed in all cases of melanonychia.
The patterns described present high sensitivity and specificity for intraoperative differential diagnosis of pigmented nail lesions.
Journal of the American Academy of Dermatology 04/2011; 65(2):297-303. · 3.99 Impact Factor
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Martin Zaiac
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ABSTRACT: Nail psoriasis affects up to 90% of patients with psoriasis in their lifetime and is seen in 80% of patients with psoriatic arthritis. These changes of nail psoriasis often cause significant pain, psychological effects, and result in restrictions of daily activities. In patients with nail psoriasis, the choice of effective therapy is limited and depends on various factors, including the severity of the disease, the ability of patients to tolerate treatment, and their ability to pay (insurance) for what are, in some cases, expensive treatments. In recent years, biological therapies have proved effective in improving nail psoriasis, have generally proved to be well tolerated and require minimal patient monitoring. In the right situation, therefore, the use of biological agents is justified in patients with psoriatic nail disease.
American Journal of Clinical Dermatology 01/2010; 11 Suppl 1:27-30. · 1.71 Impact Factor
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ABSTRACT: Palmar hyperhidrosis is an uncomfortable condition that can severely affect a patient's quality of life. Injections of botulinum toxin have proven to be an efficient treatment modality, however the pain associated with palmar injections has limited the use of this therapy.
The authors describe a novel method of analgesia combining topical analgesic cream and forced cold air during botulinum injection treatment of palmar hyperhidrosis.
This is a case report of a patient with a 10-year history of palmar hyperhidrosis. Both hands were pretreated with topical anesthetic cream and the right hand was additionally treated with forced cold air at a distance of 1 cm for up to 30 seconds before injection administration. After the botulinum injection was administered to both hands, the patient was subjectively asked about pain during injection.
The patient subjectively reported a 75% decrease in the intensity of pain with the combination use of topical anesthetic cream and forced cold air, which she said made the injections more tolerable. No epidermal changes were noted at the time of treatment or at follow-up.
The use of botulinum toxin for the treatment of palmar hyperhidrosis is limited due to the pain associated with injections of the palm. In this case report, we describe the successful use of forced cold air with topical anesthetic cream to lessen the pain of botulinum toxin injections during the treatment of hyperhidrosis.
Journal of drugs in dermatology: JDD 10/2009; 8(10):948-51. · 1.57 Impact Factor
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Journal of the American Academy of Dermatology 11/2006; 55(4):693-4. · 3.99 Impact Factor
