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ABSTRACT: The predictive value of the metabolic syndrome (MetS) for mortality from all-cause and cardiovascular disease (CVD) in the Chinese population is unclear. The aim of this present study was to compare MetS with its individual components as predictors of mortality in Chinese elderly adults.
A cohort of 1,535 subjects (994 men and 541 women) aged 50 years or older was selected from employees of a machinery factory in 1994 and followed until 2009. Cox models were used to estimate the hazard ratios (HRs) predicted by MetS according to the harmonized definition and by its individual components.
The baseline prevalence of MetS was 28.0% in men and 48.4% in women. During a median follow-up of 15 years, 414 deaths occurred, of these, 153 participants died from CVD. Adjusted for age and gender, the HRs of mortality from all-cause and CVD in participants with MetS were 1.47 (95% confidence interval (CI): 1.20-1.80) and 1.96 (95%CI: 1.42-2.72), respectively, compared with those without MetS. Non-significant higher risk of CVD mortality was seen in those with one or two individual components (HR = 1.22, 95%CI: 0.59-2.50; HR = 1.82, 95%CI: 0.91-3.64, respectively), while a substantially higher risk of CVD mortality only appeared in those with 3, 4, or 5 components (HR = 2.81-3.72), compared with those with no components. On evaluating the MetS components individually, we found that, independent of MetS, only hypertension and impaired glucose predicted higher mortality.
The number of positive MetS components seems no more informative than classifying (dichotomous) MetS for CVD risks assessment in this Chinese cohort.
Journal of Geriatric Cardiology 06/2012; 9(2):123-9.
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Yao He,
Bin Jiang,
Liang Shou Li,
Lan Sun Li,
Lisanne Ko, Lei Wu,
Dong Ling Sun,
Shu Fang He,
Bao Qing Liang,
Frank B Hu,
Tai Hing Lam
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ABSTRACT: BACKGROUND:Prospective evidence on the association between secondhand smoke (SHS) and ischemic stroke and chronic obstructive pulmonary disease (COPD) is scarce. METHODS:We prospectively examined the relationship between SHS and major tobacco related deaths, particular COPD and stroke, in 910 (439 men and 471 women) Chinese who never smoked from a 17 year follow up study in Xi'an, China. SHS exposure was defined as exposure to another person's tobacco smoke at home or in the workplace. RESULTS:At baseline among 910 subjects (439 men), 44.2% were exposed to SHS at home, 52.9% in workplaces, and 67.1% at home or work. From 1 March 1994 to 1 July 2011, 249 (150 men and 99 women) died within 14,016 person-years.Those who were exposed to SHS had increased mortality due to coronary heart disease (CHD) (adjusted relative risk, RR=2.15, 95% confidence intervals, CI=1.00-7.66), ischemic stroke (2.88, 1.10-7.55), lung cancer (2.00, 0.62-6.40), and COPD (2.30, 1.06-5.00) and all-causes (1.72, 1.29-2.20), with significant dose-response relationships between cumulative SHS exposure at home and work and the increased risk of cause-specific and total mortality (P for linear trend ranged from 0.045 to <0.001). CONCLUSIONS:This study has shown dose response relationships between SHS and major tobacco related mortality, and provided new evidence to support causation for COPD and ischemic stroke.
Chest 05/2012; · 5.25 Impact Factor
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Yao He,
Tai-hing Lam,
Bin Jiang,
Qing-hui Liu,
Fang Zuo,
Xiao-yong Sai,
Chang-xi Zhou,
Lin Zou, Lei Wu,
K K Cheng,
S C Sophia Chan
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ABSTRACT: To study the intervention programs on smoking cessation in a general hospital and to evaluate its effects of the programs. Four methods including: a) the intervention through specialists in the smoking cessation clinic, b) short-time intervention in the out-patient department, c) free medical intervention, d) group intervention, were adopted for different smokers, with health counseling, psychological intervention and drug treatment. Intervention effect was evaluated by standard methods. During the 20-month period of the project, we treated 690 cases and 402 completed 6-month follow-up. Preliminary results in 402 cases showed that the three methods of smoking cessation interventions could reduce the amount of cigarette smoking and increase the quitting rate. Motivation to quit smoking, intervention methods and intensity of intervention seemed the main factors. The quit rate of 6-month follow-up in the 'specialist intervention' in the smoking cessation clinic (31.6%) and in the group intervention (30.9%) was higher than short-time intervention in free medical events (15.1%). The successful rate of smoking cessation depended on the motivation of quitters, and the attitude, methods and intervention skills of the physicians. Therefore, it is necessary to explore and develop smoking cessation service models suitable to national context and individual intervention methods in China.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 02/2011; 32(2):192-5.
