[Show abstract][Hide abstract] ABSTRACT: Seven phenolic compounds: 3-O-caffeoylquinic acid (1), 4-O-caffeoylquinic acid (2), 5-O-caffeoylquinic acid (3), protocatechulic acid (4), caffeic acid methyl ester (5), quercetin 3-O-β-D-glucopyranoside (6) and kaempferol 3-O-β-D-glucopyranoside (7) were isolated for the first time from the leaves and twigs of Heynea trijuga. Structures of these compounds were elucidated on the basis of spectroscopic data.
The Japanese Journal of Pharmacognosy. 08/2014; 68(2):97.
[Show abstract][Hide abstract] ABSTRACT: Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.
Journal of Natural Products 04/2013; · 3.29 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Nepal, the Himalayan kingdom is rich in medicinal plant resources. Himalayan medicinal plants are very popular since the Vedic period. Details on all of these plants are still to be known. Although the plant morphology, distribution and medical uses are known but chemical aspects of these plants is still behind. An attempt has been done to include information on chemical aspects in this book.
This book is produced as a supplement I of “A Handbook of Medicinal Plants of Nepal” and includes 150 important medicinal plants occurring in Nepal. The enumeration of the plants is arranged alphabetically according to the scientific names. Every effort has been made to enlist all the reputable medicinal plants of Nepal with their local names. Illustration, description, uses and distribution map of each species are provided and an attempt has been made to include the chemical constituents of the Nepalese medicinal plants derived from secondary sources, references of which are also provided. An appendix of 544 medicinal plant species with local names is included and glossary of medical terms is provided. It is hoped that this book may be able to provide a lucid discourse on the subject to the person seeking a brief information on the topics.
04/2013; Non-profit Organization Ayur Seed Life Environmental Institute (Ayurseed L.E.I.)., ISBN: 978-4-9906572-0-8
[Show abstract][Hide abstract] ABSTRACT: Chyuri (Diploknema butyracea (Roxburgh) H. J. Lam) is widely used in Nepal for its medicinal properties and as a source of Chyuri ghee (fat) extracted from the seeds. The main purpose of the present study was the GC-MS analysis of fatty acids in seed fat of Chyuri after acidic methanolysis. Palmitic acid methyl ester (1), linoleic acid methyl ester (2), oleic acid methyl ester (3) and steric acid methyl ester (4) were identified as the main components. Ethnomedicinal use and distribution of Chyuri in Nepal is also discussed.
[Show abstract][Hide abstract] ABSTRACT: Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4-6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC(90) 0.40 nM) with the lowest cytotoxicity (IC(50) 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.