Elizabeth Miller

Publications (2)19.49 Total impact

• Article: Transforming ER exit: protein secretion meets oncogenesis.

  Silvere Pagant, Elizabeth Miller
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  ABSTRACT: COPII-coated vesicles drive protein export from the endoplasmic reticulum (ER), although the regulation of this event, both spatially and kinetically, remains unclear. TFG is now defined as a factor that modulates recruitment of the coat and links ER sequestration of kinases to oncogenesis.
  Nature Cell Biology 05/2011; 13(5):525-6. · 19.49 Impact Factor
• Chapter: COP-Mediated Vesicle Transport

  Silvere Pagant, Elizabeth Miller, Nava Segev
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  ABSTRACT: Transport of lipid and protein within the early secretory pathway is mediated by small transport vesicles that act as molecular taxis, shuttling cargoes between the endoplasmic reticulum (ER) and Golgi apparatus and within the Golgi. These vesicles are sculpted from donor organelles by distinct sets of cytoplasmic coat proteins that deform the lipid bilayer into a highly curved structure while selecting specific cargo proteins for efficient delivery to the acceptor organelle. The COPII coat generates vesicles from the ER membrane that transport newly synthesized proteins to the Golgi, whereas the COPI coat creates vesicles that mediate both retrograde Golgi-to-ER and intra-Golgi trafficking. These distinct cytoplasmic coats represent the minimal machinery required for vesicle formation and share some common mechanisms to drive intracellular protein transport. This chapter highlights the molecular details of COPII- and COPI-mediated vesicular traffic.
  12/2008: pages 143-158;