Bonnie An Henderson

University of Toronto, Toronto, Ontario, Canada

Are you Bonnie An Henderson?

Claim your profile

Publications (40)122.96 Total impact

  • Source
    David F Chang · Rosa Braga-Mele · Bonnie An Henderson · Nick Mamalis · Abhay Vasavada ·
    [Show abstract] [Hide abstract]
    ABSTRACT: A 2014 online survey of the American Society of Cataract and Refractive Surgery members indicated increasing use of intracameral antibiotic injection prophylaxis compared with a comparable survey from 2007. Forty-seven percent of respondents already used or planned to adopt this measure. One half of all surgeons not using intracameral prophylaxis expressed concern about the risks of noncommercially prepared antibiotic preparations. Overall, the large majority (75%) said they believe it is important to have a commercially available antibiotic approved for intracameral injection. Assuming reasonable cost, the survey indicates that commercial availability of Aprokam (cefuroxime) would increase the overall percentage of surgeons using intracameral antibiotic injection prophylaxis to nearly 84%. Although the majority used topical perioperative antibiotic prophylaxis, and gatifloxacin and moxifloxacin were still the most popular agents, there was a trend toward declining use of fourth-generation fluoroquinolones (60%, down from 81% in 2007) and greater use of topical ofloxacin and ciprofloxacin (21%, up from 9% in 2007). Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
    Journal of Cataract and Refractive Surgery 06/2015; 41(6):1300-5. DOI:10.1016/j.jcrs.2015.01.014 · 2.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Endophthalmitis is a rare but potentially devastating complication of cataract surgery. This article presents an overview of endophthalmitis prophylaxis and the use of intracameral antibiotics. It highlights available intracameral antibiotics with respect to pharmacology, spectrum of activity, dosage and preparation, safety, and efficacy profiles, as well as toxic anterior segment syndrome risks to better define the potential use of these medications in the prevention of endophthalmitis. Proprietary or commercial disclosures are listed after the references. Copyright © 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
    Journal of Cataract and Refractive Surgery 11/2014; 40(12). DOI:10.1016/j.jcrs.2014.10.010 · 2.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective This study utilized a phone survey to characterize patient perceptions of cataract surgery and the manner in which the ophthalmologist contributes to the patient’s understanding in electing cataract surgery. Patients and methods Calls were made from a randomized membership list of the American Association of Retired Persons until 1,000 respondents 50 years of age or older had been recruited. Three groups were recruited: persons with no prior diagnosis of cataracts, persons diagnosed with cataracts but who had not had surgery, and persons who had had cataract surgery on both eyes within the past 5 years. A series of fixed-choice and open-ended questions was then presented to qualified participants. Questions related to vision, quality of life, and the understanding and perceptions of cataract surgery. Results Two-thirds of respondents reported having frequent eye examinations. More than half indicated that they had discussed cataract surgery with an eye doctor, most often with an ophthalmologist. They reported that the benefits of surgery were most often mentioned (68%), but lens options were infrequently mentioned (39%). Of those who had had surgery, 81% elected to do so on the advice of their health care professional. About 85% of respondents who had had surgery felt well educated about the procedure, though only 75% felt they understood their lens and vision options. Three-quarters of those who had had cataract surgery wished they had had the surgery sooner, and reported that they were enjoying life more after surgery. Conclusion The ophthalmologist plays an important role in preparing patients for cataract surgery. Discussing both the timing of the surgery and the patient’s lens options are critical for appropriate care; the survey results suggest room for improvement in this regard. Respondents reported they wished they had had surgery sooner, based primarily on their improved quality of life postoperatively.
    Clinical ophthalmology (Auckland, N.Z.) 08/2014; 8:1595-602. DOI:10.2147/OPTH.S69133
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: To compare the impact of varying fluidic parameters on intraoperative intraocular pressure (IOP) fluctuations and postoperative outcomes. Methods: Prospective randomized study of 80 eyes undergoing cataract surgery that were randomly assigned to low (aspiration flow rate: 20 cc/min; bottle height: 90 cm; vacuum: 400 mm Hg) and high (aspiration flow rate: 40 cc/min; bottle height: 110 cm; vacuum: 400 mm Hg) fluidic parameter groups. Real-time dynamic intraoperative IOP was measured during nuclear fragment removal. Mean maximum and minimum IOP and percentage reduction in IOP from maximum were compared between groups. Postoperatively, the rate of change in central corneal thickness and anterior chamber inflammation at days 1 and 7, endothelial cell density at 3 months, and corneal clarity on day 1 were compared. Results: Minimum IOP in the low and high parameters groups was 35 ± 4.0 and 34.5 ± 6.8 mm Hg, respectively. Maximum IOP in the low and high parameters groups was 69 ± 3.0 and 85 ± 1.2 mm Hg, respectively (P < .002). Mean percent reduction from maximum was 59% in the high parameters group compared to 41% in the low parameters group, with the difference being statistically significant (P < .002). Rate of change in central corneal thickness was greater in the high parameters group at postoperative days 1 and 7 (P < .001). Anterior chamber inflammation and corneal clarity on the first postoperative day were significantly better in the low parameters group. Conclusions: Higher aspiration flow rate and bottle heights are associated with high intraoperative IOPs of up to 85 mm Hg. Prolonged elevated IOP during cataract surgery was found to have more anterior segment inflammation and more edematous corneas.
    Journal of refractive surgery (Thorofare, N.J.: 1995) 07/2014; 30(8):534-540. DOI:10.3928/1081597X-20140711-06 · 3.47 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This article presents an extensive overview of best clinical practice pertaining to selection and use of multifocal intraocular lenses (IOLs) currently available in the United States. Relevant preoperative diagnostic evaluations, patient selection criteria, counseling, and managing expectations are reviewed, as well as how to approach patients with underlying ocular intricacies or challenges and best practices for intraoperative challenges during planned implantation of a multifocal IOL. Managing the unhappy multifocal IOL patient if implantation has been performed is also addressed. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.
    Journal of Cataract and Refractive Surgery 02/2014; 40(2):313–322. DOI:10.1016/j.jcrs.2013.12.011 · 2.72 Impact Factor
  • Bonnie An Henderson ·

    Journal of Cataract and Refractive Surgery 01/2014; 40(1):162-3. DOI:10.1016/j.jcrs.2013.10.021 · 2.72 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the results of thin-flap laser in situ keratomileusis (LASIK) using a femtosecond-laser platform for flap creation. Institute of Vision and Optics, Faculty of Medicine, University of Crete, Heraklion, Greece. Prospective interventional case series. Patients had LASIK with the FS200 femtosecond laser for flap creation and the Allegretto Wave Eye-Q excimer laser. Flap thickness was set at 105 μm. All eyes were examined 1 month postoperatively. Flap thickness was assessed with anterior segment optical coherence tomography using the manual flap tool at 5 locations on a horizontal B scan. This study comprised 50 eyes of 25 patients (mean age 28 years ±5.72 [SD]); 42 eyes completed 6 months of follow-up. Preoperatively, the mean sphere was -3.61 ± 1.87 diopters (D) and the mean cylinder, -1.08 ± 1.23 D. Six months postoperatively, no eye lost lines of corrected distance visual acuity (CDVA), 29% gained 1 line, and 7% gained 2 lines. The mean spherical equivalent was -0.03 ± 0.42 D (range -0.88 to +0.88 D); 86% had an uncorrected distance visual acuity of 20/20 or better. The mean central flap thickness at 1 month was 102.98 ± 6.33 μm (range 91 to 114 μm). There were no intraoperative or postoperative complications. No significant complications occurred after treatment with this new femtosecond-laser platform in thin-flap LASIK. Clinical (visual and refractive) results were satisfactory in terms of safety, predictability, and stability. Dr. Henderson is a consultant to Alcon Laboratories, Inc., and Baush & Lomb, Inc. No other author has a financial or proprietary interest in any material or method mentioned.
    Journal of Cataract and Refractive Surgery 06/2013; 39(9). DOI:10.1016/j.jcrs.2013.03.024 · 2.72 Impact Factor

  • Ophthalmology 10/2012; 119(10):2191. DOI:10.1016/j.ophtha.2012.05.025 · 6.14 Impact Factor
  • Bonnie An Henderson · Julia Schneider ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Benefits of sequential surgery include assessment of the outcome of the first surgery to tailor the surgical technique, intraocular lens (IOL) power, and choice of IOL for the second surgery. Additionally, recovery may be prolonged from corneal edema, anterior chamber inflammation, or cystoid macular edema. Allowing the patient to maintain visual function in one eye during the recovery of the other eye can be important. Therefore, the few benefits of simultaneous surgery are greatly outweighed by risks of bilateral complications, inability to foresee refractive outcome, inability to alter IOL choice, potential loss of physician reimbursement, and possible increased legal ramifications.
    Survey of Ophthalmology 09/2012; 57(6):580-3. DOI:10.1016/j.survophthal.2012.05.001 · 3.85 Impact Factor
  • Bonnie A Henderson · E Bo Yang ·
    [Show abstract] [Hide abstract]
    ABSTRACT: To present a simple technique to remove a one-piece, acrylic AcrySof (Alcon Laboratories Inc) intraocular lens (IOL) via the original incision. The AcrySof IOL is removed via the original (2.75-mm) incision, without cutting or folding the IOL or widening the incision. After the IOL is viscodissected from the capsular bag and brought into the anterior chamber, toothed forceps hold the optic through the incision while the manipulator enters the side-port incision and hooks onto the optic 180° away. With the forceps pulling and the lens manipulator pushing the IOL toward the incision, the IOL will fold and be delivered. A one-piece, acrylic (Acrysof) IOL can be removed without cutting or folding the lens and without widening the original 2.75-mm incision.
    Journal of refractive surgery (Thorofare, N.J.: 1995) 06/2012; 28(7):499-502. DOI:10.3928/1081597X-20120531-01 · 3.47 Impact Factor
  • J Y Kim · M-W Jo · S C Brauner · Z Ferrufino-Ponce · R Ali · S L Cremers · B A Henderson ·

    Eye (London, England) 04/2012; 26(7):1026-7. DOI:10.1038/eye.2012.71 · 2.08 Impact Factor
  • Julia Schneider · Bonnie An Henderson ·

    International ophthalmology clinics 01/2012; 52(2):1-10. DOI:10.1097/IIO.0b013e31824b43c3
  • J Y Kim · M-W Jo · S C Brauner · Z Ferrufino-Ponce · R Ali · S L Cremers · B A Henderson ·

    Eye (London, England) 11/2011; 26(2). DOI:10.1038/eye.2011.274 · 2.08 Impact Factor
  • Bonnie An Henderson · Richard Potvin ·

    Ophthalmology 09/2011; 118(9):1895-6; author reply 1896-7. DOI:10.1016/j.ophtha.2011.04.020 · 6.14 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the efficacy and ocular safety of bromfenac ophthalmic solution (bromfenac) 0.09% dosed once daily for the treatment of ocular inflammation and pain after cataract surgery with posterior chamber intraocular lens implantation. Randomized, double-masked, vehicle-controlled or active-controlled, multicenter, clinical trials. A total of 872 subjects (872 study eyes: bromfenac in 584, placebo in 288). Four randomized, double-masked, vehicle or active-controlled, clinical trials were conducted at 134 ophthalmology clinics in the United States. Subjects aged ≥ 18 years were randomized to receive either bromfenac 0.09% or placebo dosed once daily beginning 1 day before cataract surgery (day -1), continuing on the day of surgery (day 0), and continuing for an additional postoperative 14 days. Subjects were evaluated for efficacy and safety on days 1, 3, 8, 15, and 22. The primary efficacy end point was cleared ocular inflammation, measured by the summed ocular inflammation score (SOIS; anterior chamber cells and flare) by day 15. The secondary efficacy end point was the number of subjects who were pain-free at day 1. The data from the 4 trials were pooled for analyses. The SOIS and ocular pain. The proportion of subjects who had cleared ocular inflammation by day 15 was significantly higher in the bromfenac 0.09% group than in the placebo group (P < 0.0001). The mean SOIS in the bromfenac 0.09% group was significantly lower than in the placebo group at days 3, 8, 15, and 22 (P < 0.0001). The proportion of subjects who were pain-free at days 1, 3, 8, and 15 was significantly higher in the bromfenac 0.09% group than in the placebo group (P < 0.0001). The incidence of adverse events reported in the bromfenac 0.09% group was significantly lower than in the placebo group (P < 0.0001). On day 15, 84.0% of the bromfenac subjects had ≥ 1-line improvement in visual acuity compared with 66.1% of placebo subjects (P < 0.0001). Bromfenac 0.09% dosed once daily was clinically safe and effective for reducing and treating ocular inflammation and pain associated with cataract surgery. Proprietary or commercial disclosure may be found after the references.
    Ophthalmology 07/2011; 118(11):2120-7. DOI:10.1016/j.ophtha.2011.04.035 · 6.14 Impact Factor
  • Source
    J Y Kim · M-W Jo · S C Brauner · Z Ferrufino-Ponce · R Ali · S L Cremers · B An Henderson ·
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to investigate the incidence of intraocular pressure (IOP) elevation after resident-performed cataract surgery and to determine variables, which influence postoperative day 1 (POD1) IOP. In all, 1111 consecutive cataract surgeries performed only by training residents between 1 July 2001 and 30 June 2006 were included. Elevated IOP was defined as ≥23 mm Hg. Surgeries were classified according to the presence of POD1-IOP elevation. Fisher's exact test and Student t-test were used to compare both groups. Multivariate analyses using generalized estimating equations were performed to investigate predictor variables associated with POD1-IOP elevation. The average preoperative IOP was 16.0±3.2 mm Hg and the average POD1-IOP was 19.3±7.1 mm Hg, reflecting a significant increase in IOP (P<0.001, paired t-test). The incidence of POD1-IOP elevation ≥23 mm Hg was 22.0% (244/1111). Presence of glaucoma and ocular hypertension, higher preoperative IOP, and longer axial length were frequently encountered variables in the POD1-IOP elevation group (all P<0.05). Using a multivariate analysis, presence of glaucoma (P=0.004, OR=2.38; 95% confidence interval (95% CI)=1.31-4.30), presence of ocular hypertension (P=0.003, OR=6.09; 95% CI=1.81-20.47), higher preoperative IOP (P<0.001, OR=3.73; 95% CI=1.92-7.25), and longer axial length (P=0.01, OR=1.15; 95% CI=1.03-1.29) were significant predictive factors for POD1-IOP elevation. IOP elevation on the first postoperative day following resident-performed cataract surgery occurred frequently (22.0%). Increased early postoperative IOP was associated with presence of glaucoma and ocular hypertension, higher preoperative IOP, and longer axial length.
    Eye (London, England) 04/2011; 25(7):929-36. DOI:10.1038/eye.2011.93 · 2.08 Impact Factor
  • Christine S Ament · Bonnie A Henderson ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Evaluate recent literature focusing on improving or assessing resident education in cataract surgery. Recently published studies outline methods of evaluating residents' performance, educational progress, and evaluating a surgical curriculum. Authors found that the rate of complications in resident-performed cataract surgery falls by 50% after the first 40 cases and stays the same for the next 20 cases. Preoperative risk factors for complications include mature cataract and abnormal zonular function. Left-handed residents had fewer complications compared with right-handed residents. Authors evaluated adherence by residents to the American Academy of Ophthalmology's Preferred Practice Patterns, and found that residents were lacking in eliciting patient's symptoms or function. A guide to establishing and maintaining a wet laboratory was published. Several studies evaluating the use of a physical-surgical simulator reported improvement in performance. The simulator was accepted and appreciated by residents. A cognitive simulation program was also found to be beneficial in improving fund of knowledge regarding cataract surgery. Teaching cataract surgery remains a difficult task. Educators continue to focus on curriculum, assessment, and complications. Resources for education are improving with establishment of wet laboratories and development of surgical simulators.
    Current opinion in ophthalmology 11/2010; 22(1):64-7. DOI:10.1097/ICU.0b013e3283415040 · 2.50 Impact Factor
  • Source
    Bonnie An Henderson · Kelly Jun Grimes ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Intraocular lenses (IOLs) that block both ultraviolet and blue wavelength light (<500 nm)were introduced in the 1990s. Since then, the potential benefits and harm from blocking blue light has been debated. We report the results of a complete review of all peer-reviewed published studies regarding the impact of blocking the transmission of blue light. Fifty-six published reports on subjects related to blue-blocking lenses including sleep disturbance, visual outcomes, cataract surgery, lens transmittance, sunlight exposure, and macular disease were found in peer reviewed journals from 1962 to 2009. Eleven reports specifically compared visual outcomes between blue-blocking IOLs and nonblue-locking IOLs. Of these, 10 independent studies (10/11, 91%) concluded that there are no significant effects of blue-blocking IOLs on various meters of visual performance including visual acuity, contrast sensitivity, color perception, and photopic, mesopic, and scotopic sensitivities. Only one group of authors reported that the use of blue-blocking IOLs may have detrimental effects on scotopic vision and circadian rhythms. However, the actual clinical significance of these potential negative effects on scotopic vision and on sleep patterns is uncertain. The benefits of blocking the transmission of blue light to the macula and the relationship between progression of age-related macular degeneration remain unclear. However, the published studies clearly state that the use of blue-blocking IOLs is not detrimental in visual acuity, color perception, and contrast sensitivity. The reported potential negative effects on scotopic vision and sleep disturbance appear to be minimal and may not be clinically relevant. (Surv Ophthalmol 55:284--289, 2010. 2010 Elsevier Inc. All rights reserved.)
    Survey of Ophthalmology 05/2010; 55(3):284-9. DOI:10.1016/j.survophthal.2009.07.007 · 3.85 Impact Factor
  • Jae Yong Kim · Bonnie An Henderson ·

    Journal of Cataract and Refractive Surgery 01/2010; 36(1):186. DOI:10.1016/j.jcrs.2009.08.018 · 2.72 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Evaluate the effectiveness of an interactive cognitive computer simulation for teaching the hydrodissection portion of cataract surgery compared with standard teaching and to assess the attitudes of residents about the teaching tools and their perceived confidence in the knowledge gained after using the tools. Case-control study. Residents at academic institutions. Prospective, multicenter, single-masked, controlled trial was performed in 7 academic departments of ophthalmology (Harvard Medical School/Massachusetts Eye and Ear Infirmary, University of Iowa, Emory University, University of Cincinnati, University of Pennsylvania/Scheie Eye Institute, Jefferson Medical College of Thomas Jefferson University/Wills Eye Institute, and the Aravind Eye Institute). All residents from these centers were asked to participate and were randomized into 2 groups. Group A (n = 30) served as the control and received traditional teaching materials; group B (n = 38) received a digital video disc of the Virtual Mentor program. This program is an interactive cognitive simulation, specifically designed to separate cognitive aspects (such as decision making and error recognition) from the motor aspects. Both groups took online anonymous pretests (n = 68) and posttests (n = 58), and answered satisfaction questionnaires (n = 53). Wilcoxon tests were completed to compare pretest and posttest scores between groups. Analysis of variance was performed to assess differences in mean scores between groups. Scores on pretests, posttests, and satisfaction questionnaires. There was no difference in the pretest scores between the 2 groups (P = 0.62). However, group B (Virtual Mentor [VM]) scored significantly higher on the posttest (P = 0.01). Mean difference between pretest and posttest scores were significantly better in the VM group than in the traditional learning group (P = 0.04). Questionnaire revealed that the VM program was "more fun" to use (24.1% vs 4.2%) and residents were more likely to use this type of program again compared with the likelihood of using the traditional tools (58.6% vs 4.2%). The VM, a cognitive computer simulation, augmented teaching of the hydrodissection step of phacoemulsification surgery compared with traditional teaching alone. The program was more enjoyable and more likely to be used repetitively by ophthalmology residents.
    Ophthalmology 12/2009; 117(2):253-8. DOI:10.1016/j.ophtha.2009.07.009 · 6.14 Impact Factor

Publication Stats

329 Citations
122.96 Total Impact Points


  • 2014
    • University of Toronto
      Toronto, Ontario, Canada
    • Tufts University
      Бостон, Georgia, United States
  • 2006-2014
    • University of Massachusetts Boston
      Boston, Massachusetts, United States
  • 2013
    • University of Crete
      • Institute of Vision and Optics (IVO)
      Retimo, Crete, Greece
  • 2005-2012
    • Harvard University
      Cambridge, Massachusetts, United States
  • 2005-2011
    • Harvard Medical School
      Boston, Massachusetts, United States