Zhan-Lin Zhou

Publications (3)0 Total impact

• Article: [Comparative analysis between cardiopulmonary exercise testing and echocardiography in patients of heart failure with normal ejection fraction.]

  Ya-Qi Ren, Ning-Fu Wang, Hao Pan, Li-Li Wang, Yi-Gang Zhong, Zhan-Lin Zhou
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  ABSTRACT: OBJECTIVE: To assess the clinical and predictive value of cardiopulmonary exercise testing (CPET) used in heart failure with normal left ventricular ejection fraction (HFNEF). METHODS: A total of 49 HFNEF patients of (New York Heart Association) NYHA class II were randomly selected from September 2010 to July 2012. The parameters of CPET and ultrasonic cardiogram (UCG) were collected at Day 3 post-admission. Person's and partial correlations were used to perform to compare CPET and UCG. RESULTS: Pearson's correlation revealed that mitral peak velocity of early filling/early diastolic mitral annular velocity (E/E', 10.14 ± 2.05) was significantly correlated with peak oxygen uptake (VO(2) peak, (24.15 ± 8.31) ml×kg(-1)×min(-1), r = -0.287, P = 0.046), carbon dioxide production (VCO(2), (1.63 ± 0.51) L/min, r = -0.429, P = 0.002), partial pressure of end-tidal carbon dioxide (PET CO(2), (39.50 ± 7.77) mm Hg, r = -0.282, P = 0.050) and minute ventilation/carbon dioxide production (VE/VCO(2), 31.69 ± 5.32, r = 0.411, P = 0.003). Early diastolic mitral annular velocity (E', (6.46 ± 1.60) cm/s) was relevant to VO(2) peak (r = 0.351, P = 0.013), VCO(2) (r = 0.452, P = 0.001), PET CO(2) (r = 0.310, P = 0.030), VE/VCO(2) (r = -0.434, P = 0.002) and respiratory exchange ratio (RER, 1.18 ± 0.13, r = 0.350, P = 0.014). After adjustment, VCO(2) was correlated with E/E' (r = -0.369, P = 0.019) and E' (r = 0.393, P = 0.010). VE/VCO(2) was relevant to E/E' (r = 0.414, P = 0.006) and E' (r = -0.334, P = 0.031). CONCLUSION: For HFNFE patients, CPET has high values of assessment and prognosis.
  Zhonghua yi xue za zhi 11/2012; 92(44):3104-3107.
• Article: [Management of coronary atherosclerotic heart disease through an alliance of community and hospital].

  Yi-gang Zhong, Ning-fu Wang, Hong Li, Shi-zun Guo, Zhan-lin Zhou, Guo-xin Tong, Jian Lin, Guo-an Sheng, Yi-bo Wang, Peng Xu, Yu Liu, Jian-wei Zou
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  ABSTRACT: To evaluate the effect of out-hospital normalized management of coronary heart disease (CAD) on the end point events such as mortality, readmission, etc, and on the compliance of patients through normalized management by an alliance of community and hospital. The samples were comprised of a total of 2000 patients in 15 communities. And 1642 patients agreed to a follow-up and signed a consent form. Ten communities were chosen as the intensive management group in which community clinicians were trained and the patient management plan was proposed and carried out. The remaining 5 communities were taken as the control group in which the community clinicians were not trained and the patients received only general management. Both groups received a follow-up of 23 months. Compared with the control group, the intensive manage group showed a lower risk of all-cause death, cardiac death and readmission due to cardiovascular events (CVE). They declined by 36.5% (OR 0.635, 95%CI 0.478-0.854), 41.5% (OR 0.585, 95%CI 0.428-0.800) and 56.1% (OR 0.439, 95%CI 0.315-0.612) respectively. The proportion of patients with NYHA III in the intensive management and control groups increased by 3.6% and 7.7% while that of the counterparts of NYHAIV in two groups increased by 1.6% and 6.4% respectively. The cardiac function in the patients of intensive management group was significantly superior to that in control group. Patients in both groups displayed an acceptable compliance to cardiac medications except for aspirin. The proportion of aspirin in the intensive management and control groups increased by 8.4% and 8.7% respectively (P<0.05). Through normalized management provided by an alliance of community and hospital, the rates of all-cause death and readmission due to CVE decrease significantly concurrently with an improvement of cardiac function and quality of life in CAD patients.
  Zhonghua yi xue za zhi 10/2010; 90(38):2675-8.
• Article: [Mechanism of cardioprotection induced by noninvasive limb ischemic preconditioning].

  Ning-Fu Wang, Jian Xu, Qiang Xia, Qin Gao, Xiao-Xiao Shi, Zhan-Lin Zhou, Lin-Lin Wang, Guo-Xin Tong, Hong Li, Pei-Zhang Li, Xiong Zhang, Feng Ling, Hao Pan, Jian-Min Yang
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  ABSTRACT: To verify the inhibitory effect of mitochondrial calcium uniporter in remote preconditioning-induced cardioprotection. By occlusion and reperfusion of left anterior descending artery, the rat hearts were subjected to 30 min regional ischemia and 120 min reperfusion in vivo. Thus the ischemic reperfusion model was established. The rats were randomly assigned to undergo one of the following maneuvers: (1) remote preconditioning; (2) ruthenium red (an inhibitor of mitochondrial calcium uniporter); (3) spermine or SB202190 (an opener of mitochondrial calcium uniporter). Remote preconditioning was elicited by three cycles of 5 min of right femoral artery occlusion interspersed with 5 min of reperfusion. The mean arterial blood pressure, heart rate and lactate dehydrogenase released in plasma were measured during reperfusion but the infarct size was measured after reperfusion. In comparison with I/R group, remote preconditioning limited infarct size [(20.4 +/- 2.5)% vs (51.0 +/- 6.0)%] and lactate dehydrogenase release [(271 +/- 9) U/L vs (339 +/- 39)U/L] during reperfusion. On the contrary, spermine or SB202190 attenuated the reduction of infarct size and lactate dehydrogenase release induced by remote preconditioning. The group of spermine was [(40.8 +/- 9.2)% vs (20.4 +/- 2.5)%] and [(383 +/- 43) U/L vs (271 +/- 9) U/L] while the group of SB202190 was [(44.3 +/- 6.8)% vs (20.4 +/- 2.5)%] and [(356 +/- 26) U/L vs (271 +/- 9) U/L]. Inhibition of mitochondrial calcium uniporter opening is involved in the remote preconditioning-induced cardioprotection.
  Zhonghua yi xue za zhi 07/2009; 89(28):1999-2002.