Zbigniew Zuber

Publications of Zbigniew Zuber

• Etanercept treatment in juvenile idiopathic arthritis: the Polish registry.

  Authors: Zbigniew Zuber, Lidia Rutkowska-Sak, Jacek Postępski, Bogna Dobrzyniecka, Violetta Opoka-Winiarska, Katarzyna Kobusińska, Piotr Gietka, Violetta Osińska, Dorota Turowska-Heydel, Izabela Szczygielska, Beata Kołodziejczyk, Anna Świątek-Baczkowska, Agnieszka Gazda, Piotr Wiland, Witold Tłustochowicz, Ewa Tuszkiewicz-Misztal

  Medical science monitor : international medical journal of experimental and clinical research. 12/2011; 17(12):SR35-42.

  To evaluate the long-term safety and efficacy of etanercept treatment in Polish patients with juvenile idiopathic arthritis (JIA). The study involved patients, fulfilling the JIA criteria of theTo evaluate the long-term safety and efficacy of etanercept treatment in Polish patients with juvenile idiopathic arthritis (JIA). The study involved patients, fulfilling the JIA criteria of the International League of Associations of Rheumatology (ILAR), who were started on etanercept therapy after methotrexate and other synthetic disease-modifying antirheumatic drugs (DMARDs) had proven ineffective. Patient data were collected in an electronic registry. Disease improvement was assessed based on Giannini's criteria. The statistical analysis involved 188 patients. Significant improvement was observed in all clinical and laboratory parameters after the first month of therapy and was maintained in the following months. ACR Pediatric 30, 50, 70, 90, and 100 improvement was observed in 81.4%, 65.9%, 27.5%, 16.2%, and 15%, respectively, of patients after 3 months and in 94.7%, 88.4%, 62.1%, 34.7%, and 26.3%, respectively, after 24 months of treatment. Throughout the 72-month safety observation period, 1162 adverse events were reported; the exposure-adjusted AE rate was 2.96 per patient per year. In patients with various subtypes of JIA resistant to conventional DMARD treatment, etanercept resulted in significant and long-lasting improvements in disease activity. Combination treatment with etanercept and a DMARD was well tolerated.

• [Juvenile spondyloarthropaties].

  Authors: Lidia Rutkowska-Sak, Iwona Słowińska, Zbigniew Zuber

  Annales Academiae Medicae Stetinensis. 01/2010; 56 Suppl 1:29-33.

  Epidemiologic, clinical, and genetic studies provide grounds for differentiation of juvenile spondyloarthropathies from other rheumatic diseases. The prevalence of spondyloarthropathies among whitesEpidemiologic, clinical, and genetic studies provide grounds for differentiation of juvenile spondyloarthropathies from other rheumatic diseases. The prevalence of spondyloarthropathies among whites is estimated at 0.7 to 1.2% and the female-to-male ratio is 1:2.5. The current classification of clinically defined and undefined forms of juvenile spondyloarthropathies is presented together with their diagnostic criteria and treatment.

• Plantar versus dorsal incision in the treatment of primary intermetatarsal Morton's neuroma.

  Authors: Christian Akermark, Hans Crone, Tönu Saartok, Zbigniew Zuber

  Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. 03/2008; 29(2):136-41.

  BACKGROUND: Only few studies have compared plantar and dorsal incisions in the treatment of primary intermetatarsal Morton's neuroma (PIMN). The results and guidelines are, however, stillBACKGROUND: Only few studies have compared plantar and dorsal incisions in the treatment of primary intermetatarsal Morton's neuroma (PIMN). The results and guidelines are, however, still controversial, mainly due to confounding factors and study design. The present study is an attempt to systematically compare the two approaches. MATERIALS AND METHODS: With a 2- to 5-year followup, we retrospectively compared the results of 125 patients (132 feet) with PIMN. All specimens had histology assessments. Longitudinal plantar incisions were performed by one experienced surgeon (n = 69) and dorsal incisions by another (n = 56). Records were reviewed, questionnaires evaluated, and physical examinations performed by one of two independent orthopaedic surgeons. RESULTS: Histology verified nerve resections in all specimens except in three cases of missed nerves in the dorsal group. There were significant differences, in favor of the plantar group, regarding long-term sensory loss, postoperative sick-leave weeks and complications. The clinical outcome regarding postoperative pain at followup and overall satisfaction rating were similar. CONCLUSION: We conclude that the two surgical approaches were comparable for clinical outcome and patient satisfaction at followup, whereas significant differences, in favor of plantar incisions, were present regarding residual sensory loss and number of complications. The more serious complication with the dorsal approach, missed neuroma, may result in an increased risk of failure with the dorsal incision.

• A prospective 2-year follow-up study of plantar incisions in the treatment of primary intermetatarsal neuromas (Morton's neuroma).

  Authors: Christian Akermark, Tönu Saartok, Zbigniew Zuber

  Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons. 02/2008; 14(2):67-73.

  BACKGROUND: The aim of this prospective study, with a mean 29 (minimum 24) months follow-up was to evaluate the outcome of surgical treatment with a longitudinal, plantar incision of primary Morton'sBACKGROUND: The aim of this prospective study, with a mean 29 (minimum 24) months follow-up was to evaluate the outcome of surgical treatment with a longitudinal, plantar incision of primary Morton's neuromas. METHODS: All 55 patients (59 feet) had their pre-and post-operative pain assessed using VAS, and pre-operative radiographs evaluated. Two independent orthopedic surgeons performed the follow-up examinations. RESULTS: Histology confirmed positive neuromas in all cases and there were only three minor complications. There was 88% reduction of pain at follow-up and 86% of all patients rated the overall satisfaction with the results as excellent or good. For those patients engaged in sports activities, the corresponding figure was 93%. CONCLUSIONS: Surgery with a plantar incision seems to be a reliable and safe intervention of primary Morton's neuromas, with only limited number of minor complications and a subjective satisfactory outcome, well in accordance with other studies, using different, surgical approaches.