[Show abstract][Hide abstract] ABSTRACT: Polymorphisms in the β subunit of the high affinity receptor for IgE (FcεRIβ) and interferon-γ (IFN-γ) genes may influence the risk of asthma. However, the results in Asian population are still debatable. We performed a meta-analysis to ascertain the association between the FcεRIβ E237G, FcεRIβ -109C/T, and IFN-γ 874T/A polymorphisms and asthma in an Asian population. Databases including PubMed, Chinese National Knowledge Infrastructure (CNKI), Weipu, and Wan Fang (Chinese) databases were searched to find the relevant studies. The effect summary odds ratio (OR) with 95% conﬁdence interval (CI) was calculated. There was no significant difference in dominant model and allele model (EG + GG vs. EE: OR = 1.14, 95%CI = 0.94-1.40; G vs. E: OR = 1.13, 95%CI = 0.95-1.34) for FcεRIβ E237G, and no significant association was observed in the subgroup analysis by age and atopic status. A significantly decreased risk of asthma was observed in allelic model (C vs. T: OR=0.88, 95%CI=0.80-0.98) for FcεRIβ -109C/T, significant association was found in dominant model (AT+TT vs. AA: OR=0.56, 95% CI=0.33-0.97) for IFN-γ 874T/A. This meta-analysis suggested that FcεRIβ E237G is not an influencing factor for asthma in Asian population. FcεRIβ -109C/T and IFN-γ 874T/A polymorphisms may be influencing factors for asthma in the Asian population.
[Show abstract][Hide abstract] ABSTRACT: The results of studies on association between CTLA-4 exon-1 +49A/G (rs231775) polymorphism and susceptibility to asthma are controversial. To derive a more precise estimation of the relationship between the CTLA-4 exon-1 +49A/G polymorphism and asthma, a meta-analysis of 15 published case-control studies was performed. 15 studies meeting our inclusion criteria comprising 4006 asthma cases and 3729 controls were included. The effect summary odds ratio (OR) and 95% confidence intervals were obtained. Publication bias was tested by funnel plot, Egger's test and heterogeneity was assessed. The combined results showed that there were significant differences in genotype distribution between asthma cases and control on the basis of all studies, GG + GA versus AA (OR = 0.76, 95% CI: 0.62-0.93; P = 0.008). When stratifying for the race, the phenomenon was found that asthma cases had a significantly higher frequency of GG/GA versus AA (OR = 0.71; 95% CI: 0.51-0.99; P = 0.04) than control in Caucasian. Stratifying subjects by age indicated an association between CTLA-4 +49 GG + GA genotype and asthma in children (OR = 0.75; 95% CI: 0.62-0.90; P = 0.002), but no association in adults (OR = 0.93; 95% CI: 0.76-1.14; P = 0.48). Furthermore, significant association was observed in atopic asthma under the fixed-effects model (GG + GA vs. AA: P = 0.03, OR = 0.81, 95% CI = 0.67-0.98, P heterogeneity = 0.22). Our meta-analysis results suggest that CTLA-4 exon-1 +49A/G polymorphism might be a risk factor for asthma susceptibility, at least in Caucasian, children, and patients with atopy status.
International Journal of Clinical and Experimental Medicine 01/2015; 8(3):3107-13. · 1.42 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene has been reported in the pathogeny of obesity. However, the results have been inconsistent. The purpose of this meta-analysis was to acquire a more accurate assessment of the association between PPAR-γ2 Pro12Ala polymorphism and obesity. PubMed, Wan Fang (Chinese) databases, Chinese Biomedical Medical databases, and Chinese National Knowledge Infrastructure were searched to identify eligible studies. Finally, 25 studies (6491 cases and 8242 controls) were enrolled in this meta-analysis. The effect summary odds ratio (OR) with 95 % confidence interval (CI) was applied. Random-effects or fixed-effects model was performed based on the heterogeneity. STATA 12.0 was applied for this meta-analysis. The combined results showed that PPAR-γ Pro12Ala polymorphism was associated with the obesity risk (Ala vs. Pro: OR = 1.55, 95 % CI 1.34–1.80; Pro/Ala vs. Pro/Pro: OR = 1.54, 95 % CI 1.31–1.82; Ala/Ala + Pro/Ala vs. Pro/Pro: OR = 1.61, 95 % CI 1.36–1.90). Subgroup analysis by ethnicity showed that there were significant associations between PPAR-γ Pro12Ala polymorphism and obesity risk in Caucasians, Asians, and Mixed population. Subgroup analysis by obesity’s cutoff points showed that the associations were found among the patients with the cutoff point of BMI ≥24 and BMI ≥30 but not among the patients with the cutoff point of BMI ≥95th percentile. These results suggested that PPAR-γ Pro12Ala polymorphism might be a risk factor for obesity susceptibility.
[Show abstract][Hide abstract] ABSTRACT: To investigate the quality of life of elderly diabetic patients and its influencing factors.
By randomized cluster sampling, we conducted a survey in 1450 elderly residents (over 60 years old) living in urban, suburban and rural areas in south and north Anhui province. We evaluated the quality of life of the elderly diabetic patients using a demographic information questionnaire and full items on Short Form (36) Health Survey (SF-36).
The elderly diabetic patients had lower scores in all dimensions of quality of life than the elderly without diabetes. Multiple linear regression analysis showed a linear regression in the quality of life among the elderly diabetic patients in terms of geographic regions, education, personality, sleep quality, and age.
Elderly diabetic patients have generally poor quality of life, which was subjected to the influences by geographic regions, education, personality, sleep quality, and age, suggesting the necessity of corresponding interventions to improve the quality of life of these patients.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 02/2014; 34(2):283-5.
[Show abstract][Hide abstract] ABSTRACT: Obesity is a risk of cardiovascular diseases. Our previous studies revealed that serum calcium level may have influence in the blood pressure to older male subjects. The aim of this study was to evaluate the relationship between total serum calcium level and overweight and obesity subjects. In our study, overweight and obesity status and total serum calcium level were measured among 2,503 subjects, at age range of 22-94 years, who were recruited for the routine health screening in 2006. The estimated mean for age (p < 0.001), white blood cell count (p = 0.037), hemoglobin concentration (p < 0.001), red blood cell count (p < 0.001), total serum calcium level (p < 0.001), total cholesterol weight (p < 0.001), HDL-cholesterol (p < 0.001), LDL-cholesterol (p < 0.001), and triglyceride (p < 0.001) of overweight and obesity subjects were significantly higher than those of non-overweight subjects. The prevalence of overweight/obesity in subjects according to the log-transformed total serum calcium level quartiles was 16.3-30.5 %. The prevalence of overweight/obesity subjects showed trends that were significant according to the total serum calcium level quartiles (p < 0.001). The odds ratios (ORs) and 95 % confidence intervals (CIs) for overweight/obesity of the second, third, and fourth quartiles compared to the lowest quartile were 1.407 (1.050-1.883), 1.543 (1.136-2.095), and 1.360 (0.995-1.859), respectively, after adjusting for sex and age (p < 0.001). These findings suggest that a higher prevalence of adult overweight/obesity is weakly associated with higher total serum calcium level in the Chinese population.
Biological trace element research 11/2013; DOI:10.1007/s12011-013-9856-8 · 1.61 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Obesity has become a major public health problem worldwide. The prevalence of obesity is rising alarmingly among children and adolescents in the People's Republic of China, with an estimated 120 million now in the obese range. It is estimated that 8% of children in the People's Republic of China are obese and 12% are overweight.
Eligible papers on the prevalence of obesity among primary school students in the People's Republic of China and published between 2006 and 2011 were retrieved from PubMed and from online Chinese periodicals, ie, the full-text databases of VIP, the Chinese National Knowledge Infrastructure, and Wan Fang. Meta-Analyst software was used to collate and analyze the detection rates cited in the papers retrieved.
After evaluation of the quality of the papers, 25 were finally included, giving a total sample population size for investigation of obesity of 219,763, in which 28,121 cases were detected. Meta-analysis showed that the combined obesity detection rate was 10.4% (95% confidence interval 8.6-12.6) among primary school students in the People's Republic of China, with a higher detection rate in boys (12.6%) than in girls (7.2%). The prevalence of obesity was higher in the north (11.8%) than in the south (9.5%), east (11.6%), and mid-west (8.0%) regions. Obesity defined according to the World Health Organization weight-for-height standard (14.3%) was higher than that using age-specific and gender-specific cutoff points for body mass index (9.0%).
Our meta-analysis found an obesity prevalence rate of 10.4%, which does not seem as high as previous reports of childhood obesity rates in other countries. However, the prevalence of childhood obesity in the People's Republic of China is still worrisome, and is likely to rise even further if we fail to take effective and practical measures now.
[Show abstract][Hide abstract] ABSTRACT: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic stroke (IS), but the results are still debatable. A meta-analysis was performed to investigate the association between the eNOS gene polymorphisms in IS risk. Case-control studies on the association between the G894T, T-786C, and 4b/a polymorphisms and IS were searched up to July 2012, and the genotype frequencies in the control group were found to be consistent with the Hardy-Weinberg equilibrium (HWE). The effect summary odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Meta-regression was used to explore the potential sources of heterogeneity. Funnel plots and Egger's test was used to estimate small study biases, and heterogeneity was assessed by chi-square-based Q-test and I-2 test There were total 6537/6475 cases/controls for G894T, 3459/3951 cases/controls for 4b/a, and 2125/2673 cases/controls for T-786C polymorphism. For G894T and 4b/a, a significant association of 894 T allele and 4a allele with increased risk of IS was found in Asians (TI + GT vs. GG: p < 0.00001, OR = 1.60, 95% CI = 138-1.79, P P-heterogeneity = 0.11; aa + ba vs. bb: P< 0.00001, OR = 1.60, 95% CI = 130-1.97, P-heterogeneity = 0.02), but not in Caucasians (TT + GT vs. GG: P = 0.60, OR = 0.94, 95% CI = 0.75-1.19, P-heterogeneity = 0.002; aa + ba vs. bb: P = 0.13, OR = 0.81, 95% Cl = 0.62-1.06, P P-heterogeneity = 0.63). For T-786C polymorphism, there were no significant differences in genotype distribution between IS and control in Asians (CC + TC vs. TT: P = 0.15, OR = 1.14, 95% Cl = 0.95-137, P P-heterogeneity = 0.94) and in Caucasians (CC + TC vs. TT: P = 0.72, OR = 0.96, 95% CI = 0.75-1.22, P-heterogeneity = 0.53). This analysis provides strong evidence that the eNOS T-786C gene polymorphism is not associated with IS, the G894T and 4b/a polymorphisms might be associated with IS, at least in Asians.
[Show abstract][Hide abstract] ABSTRACT: To assess the methodology and quality on Meta-analysis used in papers being published in the Chinese Journal of Epidemiology.
Computerized literature searching was carried out in Wanfang Medical Online to collect articles that Meta-analysis was used in the Chinese Journal of Epidemiology since it was founded till December, 2012. Manual retrieval was also conducted. Two researchers independently screened for literature and extracted data. Disagreements were resolved through discussion or by resort to a third reviewer if consensus was not reached. Qualities on methodologies or on the processes of reporting and reviewing, were evaluated by both AMSTAR and PRISMA scales. Statistical calculations and analyses were performed using SPSS 13.0.
Fifty-five papers on meta-analyses were included in this study. Results on the qualities of methodology or evaluation showed that only 2 articles(3.6%)were rated as high, 35 articles(63.7%) as moderate and 18(32.7%)as low. The quality on methodology being used in literature had improved since 2008. However, there were still some problems seen in the following areas as the list of studies (included and excluded), comprehensive search on literature, quality of the included studies having been assessed and documented, etc. Results on evaluation of quality showed that the included reviews had high quality on the titles of the report, sources of information, summary measures and synthesis of results. However, areas as:structured summary, methods on searching, data collection, risk of bias in individual studies, summary of evidence, limitations, funding etc., were still lack of comprehensive reports.
Articles on Meta-analysis published in the Chinese Journal of Epidemiology provided substantial evidence for more reliable information on the etiology and risk factors of the studies. However, both of the qualities on methodology and reports in the included literature presented problems at different levels that called for careful improvement.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 08/2013; 34(8):819-825.
[Show abstract][Hide abstract] ABSTRACT: Abstract The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and diabetic nephropathy (DN) or diabetes mellitus (DM) risk has been widely reported, but the results are still debatable. To investigate the role of MTHFR C677T polymorphism on DM or DN, 13 separate studies in the Chinese population on the relation between MTHFR C677T polymorphism and DM or DN were analyzed by a meta-analysis. Five genetic models were used to estimate the association between MTHFR C677T polymorphism and the risk of DM or DN. Overall, our meta-analysis for DN versus healthy controls produced significant results for all genetic contrasts except for the co-dominant model (allele contrast: OR = 2.24, 95%CI: 1.88-2.65, p < 0.00001, Pheterogeneity = 0.49). However, the meta-analysis for DM versus healthy controls produced non-significant results for all contrasts (allele contrast: OR = 1.12, 95%CI: 0.92-1.35, p = 0.25, Pheterogeneity = 0.07). In addition, the meta-analysis for DM versus DN produced significant results for all contrasts (allele contrast: OR = 1.88, 95%CI: 1.65-2.15, p < 0.00001, Pheterogeneity = 0.83). The current meta-analysis suggested that MTHFR C677T polymorphism might influence DN risk, but not for DM in the Chinese population.
[Show abstract][Hide abstract] ABSTRACT: The association between transforming growth factor-β1 (TGF-β1) gene polymorphisms and Alzheimer's disease (AD) risk has been widely reported, but results were somewhat controversial and underpowered. To derive a more precise estimation of the relationship between TGF-β1 polymorphisms and AD risk, we conducted a meta-analysis of all available case-control studies relating the T869C and/or C-509T polymorphisms of the TGF-β1 gene to the risk of developing AD. Eligible articles were identified by search of databases including Pub Med, Web of Science, the Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and the Wan Fang (Chinese) for the period up to March 2012. Finally, a total of 14 articles were identified, 10 with 1,657 cases and 6,971 controls for T869C polymorphism and 8 with 2,618 cases and 7,473 controls for C-509T polymorphism. The pooled ORs were performed for the allele contrasts, additive genetic model, dominant genetic model and recessive genetic model, respectively. Subgroup analysis was also performed by ethnicity. With respect to T869C and C-509T polymorphism, the combined results showed that there were no significant differences in genotype distribution between AD and control based on all studies. When stratifying for the race, there were also no statistically significant differences in genotype distribution between AD and controls. This meta-analysis did not provide an evidence of confirming association between the T869C and/or C-509T polymorphisms of the TGF-β1 gene and AD.
[Show abstract][Hide abstract] ABSTRACT: To explore the physical and mental health status on the 'left behind' students in Anhui province and the related influential factors.
Stratified cluster sampling method was used to investigate the 682 out of 3421 students from 7 middle schools in both south and north Anhui province, using multidimensional sub-health questionnaire of adolescents (MSQA) and mental health test (MHT), for assessment of the general condition, physical and mental health status.
14.22% of the 'left behind' students were in sub-health condition compared to 11.28% among the normal students, and the mental sub-health status represented 13.64% for the former and 10.84% for the latter. In addition, the 'left behind' students appeared less content with their life than those of staying with their parents (P < 0.05). MHT scores in the subjects were positively correlated with the scores on MSQA and showed significant difference (P < 0.01).
from the multiple linear regression analysis showed that the mental health condition among the left behind students was in linear regression relationship with the decreased physical activity (β = 1.456, P = 0.001), emotional problems (β = 1.096, P = 0.000) and problems of social adaptation (β = 1.011, P = 0.006). The status of physical sub-health in the Anhui province showed that there was no significant difference in each of the study group (P > 0.05).
Decreased physical activity and emotion aporia as well as difficult social adaptation were major factors leading to degenerated mental health levels in the 'left-behind' adolescents. The findings suggested that the mental health status could be improved in this population through better management on their body-health condition.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 07/2012; 33(7):681-4.
[Show abstract][Hide abstract] ABSTRACT: By exploring the mental health situation of the unattended adolescents in Anhui province. This study aimed at investigating the status of mental health and related influential factors to provide evidence for effective strategies and intervention in physical and mental health improvement of this population.
By using stratified cluster sampling method, we conducted an investigation on 3421 subjects, in which 682 were unattended adolescents, from 7 middle schools in both south and north parts of Anhui province. MHT was used to assess the general condition and status of mental health in the adolescents.
In the population aged 10 to 18 in Anhui province, 19.94% of them were unattended adolescents and were found with poor mental health and more prone to loneliness, sensitive and stronger fear as compared with those with parents around, which showed statistical difference (P < 0.05). As for the mental health status of unattended adolescents in different family types, the subjects seemed worse in the north than in the south Anhui regarding the total scores of MHT, self-accusation, physical symptoms and phobic anxiety disorder (P < 0.05). Girl students were also inferior to boys concerning the total scores of MHT, learning anxiety, interpersonal anxiety, self-accusation, sensitivity, physical symptoms and impulsive behavior (P < 0.05). The students in Grade 7 scored lower than those of the upperclassmen on MHT (P < 0.05), and the subjects from township were superior to those of rural areas regarding interpersonal anxiety and loneliness (P < 0.05). Children with siblings appeared worse than their counterparts on the total scores of MHT, including the items of interpersonal anxiety, learning anxiety, self-accusation, sensitivity, physical symptoms, strong fear and impulsive behavior (P < 0.05).
Generally, the mental health status of unattended adolescents in Anhui province appeared poorer than their counterparts, and relatively worse psychological status was seen in girls, high school students, children with siblings and subjects living in north Anhui or rural areas.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 12/2010; 31(12):1359-62.