Yubao Wang

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

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Publications (2)8.16 Total impact

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    ABSTRACT: Activating mutation of K-ras and inactivation of DPC4 are two common genetic alterations that occur in the development and progression of pancreatic ductal adenocarcinomas (PDAC). A separate common event in PDAC progression is increased expression of phosphotyrosine kinase receptors (PTKRs). In our study, we examined whether activating mutations of K-ras and loss of Smad4 play a role in causing the aberrant expression of PTKRs. Immortalized human pancreas ductal cells (HPNE) were genetically modified by expressing oncogenic K-ras and/or by shRNA knockdown of Smad4. EGFR and erbB2 protein levels but not Ron or IGF-1R were substantially upregulated in HPNE cells that express K-ras((GD12)). The increased expression of EGFR in HPNE cells that expressed K-ras((GD12)) was mediated by both stabilizing EGFR protein and by increasing EGFR transcription. TGF-beta signaling partially suppressed K-ras((GD12)) induced EGFR transcription in Smad4 intact HPNE cells; whereas knockdown of Smad4 in cells expressing K-ras((GD12)) further enhanced expression of EGFR and erbB2. The upregulation of EGFR and erbB2 was associated with an increase of invasion, which was blocked by a kinase inhibitor of EGFR. Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion.
    International Journal of Cancer 11/2010; 127(9):2076-87. DOI:10.1002/ijc.25412 · 5.09 Impact Factor
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    James W Freeman · Yubao Wang · Francis J Giles ·
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    ABSTRACT: Commentary to:Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancerStephen G. Chun, Weiqiang Zhou, Nelson S. Yee
    Cancer biology & therapy 08/2009; 8(14):1340-2. DOI:10.4161/cbt.8.14.8756 · 3.07 Impact Factor

Publication Stats

17 Citations
8.16 Total Impact Points


  • 2009-2010
    • University of Texas Health Science Center at San Antonio
      • • Division of Hematology/Oncology
      • • Department of Medicine
      San Antonio, Texas, United States