Yoshiyuki Ichihashi

Keio University, Tokyo, Tokyo-to, Japan

Are you Yoshiyuki Ichihashi?

Claim your profile

Publications (4)8.73 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the possible advantages of combination therapy with diquafosol tetrasodium and sodium hyaluronate for dry eye after laser in situ keratomileusis (LASIK). Prospective randomized comparative trial. A total of 206 eyes of 105 patients who underwent LASIK were enrolled in this study. Patients were randomly assigned to 1 of 4 treatment groups according to the postoperative treatment: artificial tears, sodium hyaluronate, diquafosol tetrasodium, and a combination of hyaluronate and diquafosol. Questionnaire responses reflecting subjective dry eye symptoms, uncorrected and corrected visual acuity, functional visual acuity, manifest refraction, tear break-up time, fluorescein corneal staining, Schirmer test, and corneal sensitivity were examined before and 1 week and 1 month after LASIK. Distance uncorrected visual acuity was significantly better in the combination group than in the hyaluronate group 1 week and 1 month after LASIK. Near uncorrected visual acuity was significantly better in the combination group than in the artificial tear and diquafosol groups 1 week and 1 month after LASIK. Distance functional visual acuity improved significantly only in the combination group 1 month after LASIK. The Schirmer value in the combination group was significantly higher than that in the hyaluronate group at 1 month after LASIK. Subjective dry eye symptoms in the combination group improved significantly compared with those in the other groups 1 week after surgery. Our results suggest that hyaluronate and diquafosol combination therapy is beneficial for early stabilization of visual performance and improvement of subjective dry eye symptoms in patients after LASIK.
    American Journal of Ophthalmology 03/2014; 157(3):616-622.e1. · 4.02 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: PURPOSE: To evaluate the levels of lipid oxidative stress markers and inflammatory cells from tears and conjunctiva of patients with Sjogren Syndrome (SS) and normal subjects. METHODS: Thirty-one eyes of 16 patients (16 females) with SS and 15 eyes of 10 healthy controls (2 males and 8 females) were examined in this prospective study. All subjects underwent Schirmer test, tear break up time, vital stainings, confocal microscopy of the conjunctiva, tear collection for HEL (hexanoyl-lysine) ELISA and conjunctival brush cytology. Brush cytology samples underwent immunohistochemistry (IHC) staining with HEL and 4HNE (4-hydroxy-2-nonenal). Haematoxylin-Eosin and IHC staining with HEL, 4HNE were also performed on conjunctival samples of SS patients and controls. RESULTS: The tear stability and vital staining scores were significantly worse in eyes of SS patients compared to controls. Conjunctival inflammatory cell density was significantly higher in SS subjects compared to controls. The numbers of conjunctival cells positively stained for HEL and 4HNE were significantly higher in SS patients compared with controls. Tear HEL concentrations correlated significantly with staining scores and inflammatory cell density in confocal microscopy. Conjunctival specimens revealed higher numbers of cells positively stained for inflammatory markers as well as HEL and 4HNE in the IHC stainings. CONCLUSION: Increase of the oxidative stress status in the conjunctiva of SS patients appears to have a role in the pathogenesis of the dry eye disease. A close relationship may exist between ROS production, lipid peroxidation related membrane damage and inflammatory processes in dry eye.
    Investigative ophthalmology & visual science 11/2012; · 3.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To report the efficacy of simultaneous keratolimbal allograft (KLAL) surgery and deep anterior lamellar keratoplasty (DALK) for limbal stem cell deficiency (LSCD). We conducted a retrospective, interventional case series of six consecutive eyes of five patients with LSCD and stromal opacity due to gelatinous drop-like dystrophy (two eyes), Stevens-Johnson syndrome (SJS, two eyes), or aniridia (two eyes). Only patients with normal lid anatomy and Schirmer test values greater than 3 mm were enrolled. DALK was performed by viscodissection followed by a thin, 360° KLAL designed by using an artificial anterior chamber. KLAL sutures were removed after 2 weeks. DALK and KLAL were successfully performed in all eyes, which were followed for an average of 17.2 ± 10.8 months. All eyes recovered a smooth corneal epithelium, although one SJS patient developed a persistent epithelial defect (PED) leading to opacification of the central cornea. Visual acuity improved by more than 2 lines in all eyes except that of the SJS patient with PED. No other complications were observed. Simultaneous DALK and thin-section KLAL is an effective treatment for ocular surface disease in patients with residual tear function and normal lid anatomy.
    Japanese Journal of Ophthalmology 11/2010; 54(6):537-43. · 1.27 Impact Factor
  • Yoshiyuki Ichihashi, Machiko Tomita, Jun Shimazaki
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the short-term results of Descemet's stripping and automated endothelial keratoplasty (DSAEK) for endothelial dysfunction. Twenty-three eyes of 23 patients with corneal edema following DSAEK were retrospectively analyzed. Corneal edema following laser iridotomy was the most common cause (13 eyes) followed by pseudophakic bullous keratopathy (5 eyes). Donor buttons prepared by the oversea eye banks were used (pre-cut donor button). They were inserted through a 5-mm incision using either the taco technique (7 eyes) or pull-through technique (16 eyes). After surgery air was injected into the anterior chamber at the end of surgery. Ten patients underwent simultaneous phacoemulsification and posterior chamber intraocular lens implantation. Corneal clarity, visual acuity, astigmatism, and endothelial cell density were investigated. Mean decimal preoperative best-corrected visual acuity was 0.05. Postoperatively, 13/23 (56.5%) patients achieved visual acuity of 0.5 or better at last follow-up. Mean postoperative astigmatism was within 2 D. Mean endothelial cell density of donor corneas was 2567 +/- 294 cells/mm2, and the mean density was 957 +/- 314 cells/mm2 6 months after DSAEK. DSAEK provided excellent refractive and reasonable visual outcomes in this shortterm observation. Prevention of endothelial loss seems to be the key to long-term success.
    Nippon Ganka Gakkai zasshi 08/2009; 113(7):721-6.