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Guang Ning,
Yufang Bi,
Tiange Wang,
Min Xu,
Yu Xu,
Yun Huang,
Mian Li,
Xiaoying Li,
Weiqing Wang,
Yuhong Chen, Yaohua Wu,
Jianing Hou,
Aiyun Song,
Yu Liu,
Shenghan Lai
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ABSTRACT: Greater bisphenol A exposure has been shown to be associated with a higher risk for self-reported adverse health outcomes, including diabetes.
To examine the association between bisphenol A exposure and type 2 diabetes in adults.
Cross-sectional study.
Songnan, Baoshan District, Shanghai, China.
3423 local residents aged 40 years or older who were enrolled from 27 June 2008 to 10 August 2009.
Urinary concentrations of bisphenol A from morning spot urine samples (exposure) and fasting plasma glucose concentration, plasma glucose concentration 2 hours after an oral glucose tolerance test, and serum insulin concentration (outcomes).
Median age of the participants was 59.0 years (interquartile range, 53.0 to 68.7 years), 40% were men, and 1087 had type 2 diabetes. The median urinary bisphenol A level was 0.81 ng/mL (interquartile range, 0.47 to 1.43 ng/mL). Clinical characteristics differed between participants with normal glucose regulation and those with impaired glucose regulation and by bisphenol A quartile, but in multivariable analyses, there was no clear association between bisphenol A levels and type 2 diabetes. The adjusted odds ratio (OR) of type 2 diabetes was slightly increased for participants in the second bisphenol A quartile (0.48 to 0.81 ng/mL) (adjusted OR, 1.30 [95% CI, 1.03 to 1.64]) and the fourth quartile (>1.43 ng/mL) (adjusted OR, 1.37 [CI, 1.08 to 1.74]) but not the third quartile (0.82 to 1.43 ng/mL) (adjusted OR, 1.09 [CI, 0.86 to 1.39]), and a test of the trend of the association was not statistically significant.
The cross-sectional study design and nonrandom sample of participants limit the conclusions that can be drawn. Many patients in the study already had diabetes, successful treatment of which could have obscured apparent associations. Dietary variables were not measured; however, this is necessary in observational studies of bisphenol A and diabetes because the presence of the chemical in the body may reflect consumption of sugared drinks in plastic bottles.
These findings do not confirm a previously reported association between urinary bisphenol A levels and self-reported type 2 diabetes.
Annals of internal medicine 09/2011; 155(6):368-74. · 16.73 Impact Factor
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ABSTRACT: To investigate the association between serum concentrations of total bilirubin (TBil) in the physiological range and metabolic syndrome (MS) in middle-aged and elderly Chinese, as well as any associations between serum TBil concentrations and insulin resistance, hyperinsulinemia, and systemic inflammation.
A cross-sectional study was conducted on 1423 individuals recruited from an urban community of Shanghai (average age 62.3 years) to investigate the relationship between bilirubin and cardiovascular diseases. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.
Total bilirubin concentrations were significantly lower in individuals with MS compared with those without (0.65 ± 0.21 vs 0.69 ± 0.22 mg/dL, respectively; P=0.002). The adjusted mean concentration of TBil decreased gradually with an increase in the number of components of MS (P(trend) < 0.0001). After adjustment for a range of potential confounders (e.g. age, sex, body mass index, smoking, alcohol intake, homeostasis model assessment of insulin resistance etc.), each 1 SD increase in TBil was found to be associated with a 17% reduction in the risk of MS (odds ratio 0.83; 95% confidence interval 0.73-0.95; P=0.006). Furthermore, after adjustment for all covariables, each 1 SD increase in TBil was found to be associated with lower odds of central obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, and hyperglycemia. Serum TBil concentrations were inversely associated with hyperinsulinemia, insulin resistance, and systemic inflammation.
Serum TBil concentrations within the physiological range were inversely associated with MS and insulin resistance, hyperinsulinemia, and systemic inflammation in middle-aged and elderly Chinese.
Journal of Diabetes 05/2011; 3(3):217-24.
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ABSTRACT: The aim of this article is to prospectively investigate the association of the liver enzyme γ-glutamyltransferase (GGT) with the development of diabetes and impaired glucose regulation (IGR) in a Chinese population. Seven hundred and sixty normoglycaemic subjects aged 40 years or older randomly selected from an urban community of Shanghai received a baseline investigation in May 2005. The participants were invited to receive a standard 75-g oral glucose tolerance test (OGTT) in November 2008. Incident diabetes and IGR were determined according to the 1999 WHO criteria. Serum GGT levels were significantly associated with incident diabetes or combined diabetes and IGR prospectively. After extensive adjustment, the diabetes risk was significantly increased with incrementing serum GGT quartiles (P value for trend = 0.0027). As compared with the lowest quartile of GGT, the highest quartile had an adjusted hazard ratio of 1.30 (95% CI 1.03-1.65) for developing combined diabetes and IGR. Furthermore, a high serum GGT level at baseline was independently associated with an increase in the index of homeostasis model assessment of insulin resistance (HOMA-IR) at follow-up. Serum GGT concentration, even within its normal range, is a risk marker for developing impaired glucose metabolism in middle-aged and elderly Chinese.
Endocrine 04/2011; 40(2):265-72. · 1.42 Impact Factor
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Lina Jin,
Yun Huang,
Yufang Bi,
Liebin Zhao,
Min Xu,
Yu Xu,
Yuhong Chen,
Lina Gu,
Meng Dai, Yaohua Wu,
Jianing Hou,
Xiaoying Li,
Guang Ning
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ABSTRACT: To assess the association of alcohol consumption with metabolic syndrome (Mets) in a Chinese population.
A community-based cross-sectional study was performed in 19,215 participants aged 40 years or over in Shanghai of China during June 2008-April 2009. Information about the alcohol consumption including quantity and type of alcoholic beverage was obtained using a standard questionnaire. Physical examination was performed and fasting blood samples were obtained for the measurements of biochemical indicators.
In male wine-only consumers, after adjusted for age, sex, BMI, education levels, exercise and smoking habit, severe alcohol consumption (≥ 50.0 g/d), compared with non-alcohol consumption, conferred 53% increased risk of having MetS. In women, alcohol consumption did not have relation to the prevalence of Mets. In the beer-only, liquor-only and mixed type consumers, no significant associations between MetS or its components and the quantity of alcohol consumption were detected.
Our findings suggest that excessive wine consumption (alcohol ≥ 50.0 g/d) is associated with higher prevalence of MetS in Chinese men.
Diabetes research and clinical practice 03/2011; 92(3):386-92. · 2.16 Impact Factor
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Aiyun Song,
Min Xu,
Yufang Bi,
Yu Xu,
Yun Huang,
Mian Li,
Tiange Wang, Yaohua Wu,
Yu Liu,
Xiaoying Li,
Yuhong Chen,
Weiqing Wang,
Guang Ning
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ABSTRACT: Previous studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin resistance in Chinese. We aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older.
A community-based cross-sectional study was performed among 5,227 Chinese adults. The average age of our study was 61.5±9.9 years. Serum fetuin-A concentrations were not significantly different between male and female (296.9 vs. 292.9 mg/l, p = 0.11). Compared with the lowest quartile, the highest quartile of serum fetuin-A revealed a significant higher proportion of type 2 diabetic patients (34.8% vs. 27.3%, p<0.0001). In the multinomial logit models, the risk of type 2 diabetes was associated with each one quartile increase of serum fetuin-A concentrations when referenced not only to normal glucose tolerance (OR 1.24, 95% CI 1.07-1.43, p = 0.004) but also to impaired glucose regulation (OR 1.25, 95% CI 1.08-1.44, p = 0.003, respectively), after adjustment for age, sex, community, current smoking, and current drinking. The logistic regression analysis showed that fetuin-A were associated with elevated HOMA-IR and fasting serum insulin both among the participants with or without type 2 diabetes in the full adjusted analysis. There was no significant association between elevated serum fetuin-A concentrations and impaired glucose regulation (all p≥0.12).
Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.
PLoS ONE 01/2011; 6(4):e19228. · 4.09 Impact Factor
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Yu Xu,
Min Xu,
Yufang Bi,
Aiyun Song,
Yun Huang,
Yu Liu, Yaohua Wu,
Yuhong Chen,
Weiqing Wang,
Xiaoying Li,
Guang Ning
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ABSTRACT: Fetuin-A is an important player in the enhancement of insulin resistance. We aimed to investigate the association of serum fetuin-A and metabolic syndrome (MetS) in a community based Chinese population.
A total of 5469 subjects aged 40 years or above were recruited from two urban communities in Shanghai. Demographic, anthropometric and biochemical features were collected according to a standard protocol. Serum fetuin-A levels were measured using ELISA and the modified NCEP-ATP III criteria were adopted to diagnose MetS.
A higher level of serum fetuin-A was well associated with a variety of metabolic disorders and an increased prevalence of MetS. The relative risks for MetS were markedly elevated in a dose-dependent manner both before and after extended adjustment in total participants (adjusted odds ratios were 1.00, 1.11, 1.20 and 1.40 for fetuin-A quartiles 1, 2, 3 and 4, respectively; P value for trend = 0.0002). MetS risks were also significantly associated with serum fetuin-A in various subgroups of sex, age, body mass index and glycaemic status. Moreover, an elevated serum fetuin-A was also independently associated with MetS components including central obesity, high blood pressure, high blood glucose and high triglycerides. Stepwise regression analyses revealed fetuin-A as an independent determinant of insulin resistance measured by the index of homeostasis model (HOMA-IR) (β = 0.064; P = 0.009).
Serum fetuin-A levels were strongly and independently associated with MetS and its components in community-dwelling Chinese adults.
Atherosclerosis 01/2011; 216(1):180-6. · 3.79 Impact Factor
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Min Xu,
Yufang Bi,
Yu Xu,
Bing Yu,
Yun Huang,
Lina Gu, Yaohua Wu,
Xiaolin Zhu,
Mian Li,
Tiange Wang,
Aiyun Song,
Jianing Hou,
Xiaoying Li,
Guang Ning
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ABSTRACT: Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese.
Subjects were enrolled in: (1) a case-control study including 1825 subjects with T2DM, 1487 with IGR and 2200 with normal glucose regulation; and (2) a prospective cohort with 734 non-diabetic subjects at baseline. The latter was followed up for 3.5 years, in which 67 subjects developed T2DM. Nineteen single nucleotide polymorphisms (SNPs) were selected to replicate in both studies. We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35. In the prospective study, the fourth quartile of risk scores based on the combined effects of the risk alleles had 3.05 folds (95% CI, 1.31-7.12) higher risk for incident T2DM as compared with the first quartile, after adjustment for age, gender, body mass index and diabetes family history. This combined effect was confirmed in the case-control study after the same adjustments. The addition of the risk scores to the model of clinical risk factors modestly improved discrimination for T2DM by 1.6% in the case-control study and 2.9% in the prospective study.
Our study provided further evidence for these GWAS derived SNPs as the genetic susceptible loci for T2DM in Chinese and extended this association to IGR.
PLoS ONE 01/2010; 5(11):e14022. · 4.09 Impact Factor
