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ABSTRACT: A method for the determination of bisphenol A (BPA) and tetrabromobisphenol A (TBBP-A) in plastic products using high performance liquid chromatography-mass spectrometry (HPLC-MS) was developed with the ultrasonic extraction. The conditions of sample pretreatment, chromatography and mass-spectrometry parameters were studied systematically. The research showed that the extraction of the BPA and TBBP-A can reach a good performance with 20 mL dichloromethane at 50 degrees C under ultrasonic extraction for 60 min. The BPA and TBBP-A were separated and detected using HPLC-MS with the mobile phase of methanol and water. The linearity range of the method was 0.1-2.0 mg/L. The detection limits were 0.01 mg/kg for BPA and 0.02 mg/kg for TBBP-A. The recoveries for the spiked samples were 85.4%-97.6%. This method is time-saving, easy-handling, practicable and sensitive, and it can be applied to determine the residues of BPA and TBBP-A in plastic products.
Se pu = Chinese journal of chromatography / Zhongguo hua xue hui 09/2010; 28(9):863-6.