Yoshiaki Furuhata

Publications (2)2.99 Total impact

• Article: Mixed squamous cell and glandular papilloma of the lung: a case study and literature review.

  Kentaro Inamura, Toshio Kumasaka, Reiko Furuta, Kei Shimada, Noriko Hiyama, Yoshiaki Furuhata, Isao Tanaka, Tamiko Takemura
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  ABSTRACT: Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is an extremely rare neoplasm, with only 10 cases reported so far in the English literature. We present a case study of endobronchial mixed papilloma with immunohistochemical and etiological investigations. A 49-year-old male with a smoking history complained of hemoptysis, presented with a lung mass closely adjacent to large vessels in the computed tomography findings, and underwent lobectomy. The 3.0-cm sized polypoid tumor was histologically diagnosed as endobronchial mixed papilloma. Immunohistochemically, intracellular mucin was positive for MUC5AC, which is expressed in tracheobronchial goblet cells. CAM5.2 and CK19 were diffusely positive, indicating that the tumor originated from the columnar epithelium by squamous metaplasia. CEA and CA19-9 were focally positive. A human papillomavirus (HPV) investigation with in situ hybridization using a wide spectrum probe and a newly-developed PCR system did not detect any HPV infection. Including this case with a detailed HPV investigation, all of the reported cases of mixed papilloma were HPV-negative, and a literature review including newly-reported cases indicated a high frequency of smoking in such cases. Endobronchial mixed papillomas might have a smoking-related etiology.
  Pathology International 04/2011; 61(4):252-8. · 1.62 Impact Factor
• Article: Local Control and Cosmetic Outcome after Sector Resection with or without Radiation Therapy for Early Breast Cancer

  Masaharu Inoue, Isao Tanaka, Ryo Masuda, Yoshiaki Furuhata
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  ABSTRACT: Breast conserving surgery and radiation therapy (RT) can achieve a more favorable cosmetic outcome than mastectomy in patients with early breast cancer. However, it is widely recognized that RT is an impediment to improving the cosmetic outcome. Between 1985 and 1993, 113 patients were enrolled in a prospective randomized study to examine whether or not RT could be avoided following sector resection in patients with Stage I and II (UICC) invasive breast cancer. There was no significant difference in the 8 year local recurrence free survival rate between the RT and non-RT groups (92.3% versus 89.8% respectively). The characteristics of suitable patients would be negative nodes and microscopically negative resection margins. In conclusion, sector resection without RT is a reasonable option for some patients with early breast cancer.
  Breast Cancer 02/1996; 3(1):39-46. · 1.36 Impact Factor