Yue Li

Chinese Academy of Sciences, Peping, Beijing, China

Are you Yue Li?

Claim your profile

Publications (85)224.52 Total impact

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Lithistid sponge-Calathium-microbial reefs were widespread on the Yangtze Platform during the Early Ordovician and are well studied. However, the biological affinity and the role of Calathium in these reefs have remained unclear up to now. We document lithistid sponge-Calathium reefs from the Upper Hunghuayuan Formation (early Floian) at Huanghuachang in Hubei, South China. These reefs have a three-dimensional skeletal framework that is mostly produced by Calathium and lithistid sponges. Calathium had a critical role in reef construction, as demonstrated by well-developed lateral outgrowths, which connected individuals of the same species and with lithistid sponges. Bryozoans, stromatoporoids and microbial components were secondary reef builders. Morphological, constructional and functional analyses provide evidence that Calathium was a sponge-grade metazoan rather than a receptaculitid alga as previously thought. At the dawn of the Ordovician Radiation, these small-scaled patch reefs thus represent the initial rebound of metazoan-dominated reefs after the late-Early Cambrian archaeocyath reef crisis. Gradual global cooling through the Early Ordovician may have been a key driver for the return of metazoan reefs.
    Palaeogeography Palaeoclimatology Palaeoecology 05/2015; 425:84-96. DOI:10.1016/j.palaeo.2015.02.034 · 2.75 Impact Factor
  • International journal of cardiology 03/2015; 187:148-150. DOI:10.1016/j.ijcard.2015.03.326 · 6.18 Impact Factor
  • Source
  • Source
  • Source
  • Dataset: Appendix S1
  • Dataset: Appendix S2
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A carbonate ramp in the shallow-marine northwestern part of the Central Tarim Uplift, Bachu, NW China, exhibits an extraordinary Late Ordovician reef complex along the Lianglitag Mountains, exposed for a distance of about 25 km. Seven localities within the ‘Middle Red Limestone’ of the Upper Member of the Lianglitag Formation (Katian, Late Ordovician) illustrated the changes in biofacies and lithofacies: northern, seaward-directed patch reefs are replaced towards the south by coeval grain banks. The patch reef units are dominated by microbial and calcareous algal components. The reefs at the northernmost locality are knoll-shaped, kalyptra-shaped or irregularly shaped with sizes of individual reefs increasing from about 2 m in height and diameter. Stratigraphically upward, reefs notably expand to larger structures by several mounds coalescing; they are generally about 10 m thick and tens of metres in lateral extent. The maximum thickness of the main patch reef is more than 30 m, and its diameter is around 100 m. The reefal units turn into biostromes with gentler relief southward and still further south grade into banks composed of peloids and coated grains. The southernmost locality is still a shallow-water bank, and the coastline is not documented in the study area. The present evidence indicates that the Late Ordovician palaeo-oceanography provided a number of environments for the optimal growth of carbonate build-ups; microbial-calcareous algal communities could thrive in areas where the innovative metazoan reef frameworks consisting of corals and stromatoporoids did not play a significant role. The ramp morphology, especially changes in water depth, controlled the configuration of the reef complex.
    Lethaia 03/2015; DOI:10.1111/let.12123 · 2.19 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Several Late Ordovician (late Katian) reef complexes are known from the border area of Jiangxi and Zhejiang provinces in southeast China. We studied two coral–stromatoporoid reefs exposed in the Xiazhen Formation at Zhuzhai (Yushan, Jiangxi). The reefs have a combined thickness of 7.4 m and are metazoan-dominated with most reef-builders in growth position. Stromatoporoids and tabulate corals constitute the framework of the reefs. Stromatoporoids (mostly Clathrodictyon) dominate the first unit and show a vertical increase in proportion and dominance from the middle part to the top of the unit, whereas tabulate corals (dominated by Catenipora and Agetolites) are the main reef-builders in the second unit where stromatoporoids are rare. We attribute this change to a greater tolerance of tabulate corals to turbidity, allowing them to thrive in the muddy facies of the upper unit. This facies change is probably related to the increasing terrestrial input from the northwestward expansion of the Cathaysian Land during the late Katian. The Cathaysian orogeny also led to a short-term exposure of the sea floor in the study area, which terminated the reef growth.
    Estonian Journal of Earth Sciences 03/2015; 64(1):68-73. DOI:10.3176/earth.2015.12 · 0.82 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Brain-derived neurotrophic factor (BDNF) is associated with coronary artery diseases. However, its role and mechanism in myocardial infarction (MI) is not fully understood. Wistar rat and Kunming mouse model of MI were induced by the ligation of left coronary artery. Blood samples were collected from MI rats and patients. Plasma BDNF level, protein expression of BDNF, tropomyosin-related kinase B (TrkB) and its downstream transient receptor potential canonical (TRPC)3/6 channels were examined by enzyme-linked immunosorbent assay and Western blot. Infarct size, cardiac function and cardiomyocyte apoptosis were measured after intra-myocardium injection with recombinant human BDNF. Protective role of BDNF against cardiomyocyte apoptosis was confirmed by BDNF scavenger TrkB-Fc. The regulation of TRPC3/6 channels by BDNF was validated by pretreating with TRPC blocker (2-Aminoethyl diphenylborinate, 2-APB) and TRPC3/6 siRNAs. Circulating BDNF was significantly enhanced in MI rats and patients. Protein expression of BDNF, TrkB and TRPC3/6 channels were upregulated in MI. 3 days post-MI, BDNF treatment markedly reduced the infarct size and serum lactate dehydrogenase activity. Meanwhile, echocardiography indicated that BDNF significantly improved cardiac function of MI mice. Furthermore, BDNF markedly inhibited cardiomyocyte apoptosis by upregulating Bcl-2 expression and downregulating caspase-3 expression and activity in ischemic myocardium. In neonatal rat ventricular myocytes, cell viability was dramatically increased by BDNF in hypoxia, which was restored by TrkB-Fc. Furthermore, protective role of BDNF against hypoxia-induced apoptosis was reversed by 2-APB and TRPC3/6 siRNAs. BDNF/TrkB alleviated cardiac ischemic injury and inhibited cardiomyocytes apoptosis by regulating TRPC3/6 channels, which provides a novel potential therapeutic candidate for MI.
    International journal of biological sciences 01/2015; 11(5):536-45. DOI:10.7150/ijbs.10754 · 4.37 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate whether microRNAs (miRs) can serve as novel biomarkers for in-stent restenosis (ISR). This retrospective, observational single-centre study was conducted at the cardiovascular department of a tertiary hospital centre in the north of China. Follow-up coronary angiography at 6 to 12 months was performed in 181 consecutive patients implanted with drug-eluting stents. Fifty-two healthy volunteers served as the control group. The plasma miRs levels were analyzed by quantitative real-time PCR. Receiver-operating characteristic curve (ROC) analysis was performed to investigate the characters of these miRs as potential biomarkers of ISR. MiR-21 levels in ISR patients were significantly higher than those in non-ISR patients and healthy controls (P<0.05), while miR-100 (P<0.05), miR-143 (P<0.001) and miR-145 (P<0.0001) levels were significantly decreased in ISR patients. Further analysis showed that miR-21 levels were remarkably increased (P = 0.045), while miR-100 (P = 0.041), miR-143 (P = 0.029) and miR-145 (P<0.01) levels were dramatically decreased in patients with diffuse ISR compared to those with focal ISR. ROC analysis demonstrated that the area under curve of miR-145, miR-143, miR-100 and miR-21 were 0.880 (95% confidence interval; CI = 0.791-0.987, P<0.001), 0.818 (95% confidence interval; CI = 0.755-0.963, P<0.001), 0.608 (95% confidence interval; CI = 0.372-0.757, P<0.05) and 0.568 (95% confidence interval; CI = 0.372-0.757, P<0.05), with specificity of 83.1%, 80.1%, 68.9% and 68.6%, and sensitivity of 88.7%, 82.1%, 60.2% and 50.1%, respectively. Circulating miR-143 and miR-145 levels are associated with the occurrence of ISR and can serve as novel noninvasive biomarkers for ISR.
    PLoS ONE 11/2014; 9(11):e112043. DOI:10.1371/journal.pone.0112043 · 3.53 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Obstructive sleep apnea (OSA) is closely related to atrial fibrillation (AF). However, the roles and mechanisms of chronic OSA in atrial remodeling are still unclear. Canine model of chronic OSA was simulated by stopping the ventilator and closing the airway for 4 h per day and lasting for 12 weeks. AF inducibility and duration was increased while atrial effective refractory period (AERP) was shortened after chronic apnea. Meanwhile, upregulation of proteins encoding inward rectifier K(+) current (I K1), delayed rectifier K(+) current (I Kr and I Ks), acetylcholine activated K(+) current (I KACh), transient outward K(+) current (I to) and ultra-rapid delayed rectifier potassium current (I Kur) as well as downregulation of protein encoding L-type Ca(2+) current (I Ca,L) were found after chronic OSA. Besides abnormal electrical activity, chronic OSA induced apoptosis and interstitial fibrosis of atrial myocytes, which was partly mediated by caspase 9, phosphorylation of extracellular-regulated kinase 1/2, and α-smooth muscle actin. In addition, atrial sympathetic and parasympathetic hyperinnervation were found manifesting by enhanced growth-associated protein 43, tyrosine hydroxylase and elevated choline acetyltransferase. Moreover, protein expression of β1, β2, and M2 receptor were markedly increased by chronic OSA. In summary, we firstly demonstrated in canine model that chronic OSA could shorten AERP and lead to altered expression of important channel proteins, moreover, induce atrial structure remodeling by increased atrial apoptosis, fibrosis, and autonomic remodeling, eventually promoting the development of a substrate of AF. Our findings suggested that reversing atrial remodeling might be a potential therapeutic strategy for OSA-induced AF.
    Archiv für Kreislaufforschung 09/2014; 109(5):427. DOI:10.1007/s00395-014-0427-8 · 5.96 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Early Ordovician (late Tremadocian to early Floian) reefs on the Yangtze Platform margin of the Hunghuayuan Formation at Zhangzhai section in southeastern Guizhou, South China show three types of reefs in two broad categories: microbial-dominated (stromatolite and lithistid sponge-Calathium-calcimicrobial) reefs and metazoan-dominated (lithistid sponge-Calathium) reefs. These reef types represent different communities controlled by varying environmental settings. Stromatolites tended to develop in the shallow subtidal zone, whereas unlaminated calcimicrobial mounds and metazoan-dominated reefs thrived at greater depths. This is the first report on metazoan-dominated reefs at the platform margin of the Hunghuayuan Formation.
    Gff -Uppsala- 05/2014; 136(1). DOI:10.1080/11035897.2013.862852 · 0.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: After the end-Ordovician mass extinction, reef recovery (size and biotic diversity) took several million years. On the Upper Yangtze Platform, South China Block, the initial reef reconstruction episode is recorded in limestone of middle Aeronian age in northern Guizhou Province. By late Aeronian, reefs were widespread on the Yangtze carbonate platform, today represented by patch reefs cropping out in a 10-km2 large area near Shuibatang, Tongzi County, where two stratigraphic intervals with reefs are recognized. Late Aeronian reefs constitute a complex and diverse reef community dominated by corals, and to a lesser extent stromatoporoids. They contain an accessory fauna of abundant bryozoans and crinoids and some brachiopods, trilobites, molluscs and calcimicrobes. These reefs correlate in time with similar reefs in Anticosti, Laurentia, palaeogeographically very distant from South China. Thus, there is good evidence that recovery and geographic expansion of reefs after the end-Ordovician extinction occur simultaneously in at least two continents.
    Gff -Uppsala- 05/2014; 136(1). DOI:10.1080/11035897.2013.853687 · 0.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Erythropoietin (EPO) and granulocyte colony-stimulating factor (G-CSF) are both potential novel therapeutics for use after myocardial infarction (MI). However, their underlying mechanisms remain unclear and the efficacy of monotherapy with EPO or G-CSF is also controversial. Therefore, we investigated the effects of combined treatment with EPO and G-CSF on neovascularization and cardiac function in post-infarction rats and explored the potential mechanisms. Four groups of rats were used: control (saline injection after MI, i.h.), EPO (a single dose of 5 000 IU/kg after MI, i.h.), G-CSF (a dose of 50 µg× kg(-1)× d(-1) for 5 days after MI, i.h.), and both EPO and G-CSF (EPO+G-CSF, using the same regiment as above). Cardiac function was assessed by echocardiography before and 1 day, 7 days, 14 days and 21 days after MI. CD34(+)/Flk-1(+) cells in the peripheral blood were evaluated by flow cytometry before and 3 days, 5 days and 7 days after MI. The infarct area and angiogenesis in the peri-infarct area were analyzed. The mRNA and protein expression of vascular endothelial growth factor (VEGF) and stromal-derived factor-1a (SDF-1α) in the peri-infarct area were detected by real-time quantitative RT-PCR and Western blotting. Compared with the control and monotherapy groups, the EPO+G-CSF group had significantly increased CD34(+)/Flk-1(+) endothelial progenitor cells (EPCs) in the peripheral blood (P < 0.05), up-regulated VEGF and SDF-1α levels in the peri-infarct region (P < 0.05), enhanced capillary density (P < 0.05), reduced infarct size (P < 0.05) and improved cardiac structure and function (P < 0.05). G-CSF alone did not dramatically increase EPCs in the peripheral blood, enhance capillary density in the peri-infarct area or reduce infarct size compared with the control group. Combined treatment with EPO and G-CSF increased EPCs mobilization, up-regulated VEGF and SDF-1α levels in the post-infarction microenvironment, subsequently enhanced neovascularization in the peri-infarct region and reduced infarct size. All factors contributed to its beneficial effects on cardiac function in post-infarction rats.
    Chinese medical journal 05/2014; 127(9):1677-83. · 1.02 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Balloon crossing failure after passing a guidewire usually leads to unsuccessful percutaneous recanalization of chronic total occlusions (CTOs). We sought to investigate a novel technique for solving this problem. Twenty-one patients with failed balloon crossing through CTOs after successful guidewire passing were treated with the "seesaw balloon-wire cutting" technique between July 2012 and May 2013. The main process of this technique was to insert two guidewires (guidewire A and guidewire B) into the distal true lumen of CTOs and then to advance two short and lowprofile balloons (balloon A and balloon B) over the two guidewires, respectively. Balloon A was first advanced over guidewire A as distally as possible, and then was inflated with high pressure (≥18 atm) to press guidewire B, producing a cutting power to crush the proximal fibrous cap of the CTO. Subsequently, balloon A was withdrawn slightly, and balloon B was advanced as distally as possible and then was inflated to press guidewire A, producing a similar cutting effect to crush the proximal fibrous cap on the other side. The two balloons were progressed alternatively until one of them was able to cross through the occluded segment. This new technique was successfully applied in 17 patients (81.0%), leading to procedural success of their CTOs. The technique failed in 4 patients (19.0%) due to heavy calcification. No complications occurred in all patients. The seesaw balloon-wire cutting technique is an effective and safe approach to facilitate balloon crossing during CTO interventions.
    The Journal of invasive cardiology 04/2014; 26(4):167-70. · 0.82 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Reefs in the Late Ordovician are usually built up by metazoans, whereas in the Early and Middle Ordovician microbial reefs are dominating. In the Late Ordovician (Katian) Lianglitag Formation, at Bachu, Tarim, NW China, however, three distinct stages of thrombolithic microbial reefs are exposed. The lower and upper reef intervals are characterized by widespread microbial carbonates with almost constant thicknesses (biostromes). The middle reef interval exposes dome-like mounds, and shows a higher diversity of reef-building and reef-dwelling organisms. Calcareous algae such as Vermiporella are abundant, but also other components such as fragments of Halysis, brachiopods, molluscs, echinoderms, bryozoans, and trilobites have been found in the microbial reef units. The purpose of this study is to describe for the first time the composition and microfacies of the reefs in this remote area. Especially the question of whether or not these Late Ordovician reefs represent remnants of the Early/Middle Ordovician microbial-dominated reef type just lacking Calathium and lithistid sponge is addressed. The results indicate that the local conditions on the leeward side of the carbonate platform, where waters are less well agitated and thus less well oxygenated, and probably also characterized by temporarily elevated water temperatures hampering the growth of metazoan reefs, were responsible for the proliferation of the Late Ordovician microbial reefs in the Bachu area.
    Facies 04/2014; 60(2). DOI:10.1007/s10347-014-0396-2 · 1.34 Impact Factor
  • International journal of cardiology 01/2014; 172(2). DOI:10.1016/j.ijcard.2014.01.027 · 6.18 Impact Factor

Publication Stats

660 Citations
224.52 Total Impact Points

Institutions

  • 2007–2015
    • Chinese Academy of Sciences
      Peping, Beijing, China
  • 2004–2015
    • Harbin Medical University
      • • Department of Cardiology
      • • Department of Pharmacology
      Charbin, Heilongjiang Sheng, China
  • 2013
    • Shenyang Pharmaceutical University
      Feng-t’ien, Liaoning, China
  • 2011
    • Capital Medical University
      Peping, Beijing, China
    • Huazhong University of Science and Technology
      • Key Laboratory of Molecular Biophysics of Ministry of Education
      Wu-han-shih, Hubei, China
  • 2010
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2009
    • National Space Science
      Peping, Beijing, China
  • 2008
    • Beijing Hospital
      Peping, Beijing, China