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Publications (5)9.61 Total impact

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    ABSTRACT: Syphilis, the "great imitator," with regard to skin diseases, is a chronic systemic infectious disease with a clinical course that waxes and wanes. The incidence of tertiary syphilis had decreased drastically these decades. We report a case of tertiary neurosyphilis presenting with moth-eaten bone lesions of the lower extremities. To the best of our knowledge, we have not seen such reports.
    Dermatologic Therapy 11/2013; 26(6):486-488. · 1.96 Impact Factor
  • The Journal of Dermatology 11/2011; 39(6):565-6. · 2.35 Impact Factor
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    ABSTRACT: Fractional photothermolysis (FP) lasers have been widely used in treating photo-aged skin, acne scars, and other skin conditions. Although plenty of clinical data have demonstrated the efficacy of the FP laser, only limited histologic studies have been available to observe serial short- to long-term skin responses. Seven healthy Chinese women received one pass of fractional carbon dioxide laser treatment on the left upper back. Biopsies were taken at the baseline and 4 hours, 1 day, 5 days, 1 month, 3 months, 6 months, and 1 year after the procedure for hematoxylin and eosin stains, immunohistochemical evaluation (for heat shock proteins and elastin), and Verhoeff-iron-hematoxylin stains (for collagen and elastic fiber). Remarkably greater expression of heat shock protein (HSP)70 could be observed 4 hours after the procedure, which diminished significantly by 3 months, 6 months, and 1 year after the procedure. HSP47 reached its peak expression 1 month after the procedure, especially around microscopic thermal zones, and maintained its high level of expression 3 and 6 months after the procedure. Distinct new formation and remodeling of collagen and elastic fibers could be observed 3 and 6 months after procedure. FP-induced HSP expression and new formation of collagen and elastic fibers lasted as long as 6 months, longer than the previously acknowledged 3 months.
    Dermatologic Surgery 06/2011; 37(8):1141-9. · 1.87 Impact Factor
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    ABSTRACT: Sporotrichosis is a chronic fungal infection with a global distribution; both sporadically occurring infections and outbreaks of cases are not uncommon. Sporothrix schenckii, as the causative agent, can be isolated from soil, wood, land, and even marine animals. We present the clinical and histopathological presentations of sporotrichosis collected in our department for about 40 years. A series of interesting pictures illustrating asteroid bodies and organism materials, which are rarely seen, are also showed. Asteroid body is characterized by the presence of radiating star-like asteroid or club-shaped eosinophilic material around spores, and 5 types of asteroid body collected in our department are presented.
    The American Journal of dermatopathology 05/2011; 33(3):296-302. · 1.30 Impact Factor
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    ABSTRACT: Alternariosis, caused by Alternaria spp., is a rare opportunistic infection often observed in immunocompromised patients. Alternaria is a ubiquitous saprophytic fungus that naturally is found on decaying plant materials. In this paper, a case of cutaneous alternariosis in association with tinea corporis is reported. The complicated infection was confirmed by histological examination and positive tissue culture. Although the cases of alternariosis in solid organ transplant recipients or Cushing's syndrome have been described elsewhere, this is the first report in a patient who had received two renal transplants who was co-infected with Alternaria spp. and Trichophyton rubrum.
    Medical mycology: official publication of the International Society for Human and Animal Mycology 12/2010; 49(4):435-8. · 2.13 Impact Factor