Xiaoyi Wei

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (75)183.71 Total impact

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    ABSTRACT: Two new metabolites, 4R*-hydroxy-3,5R*-dimethoxycyclohex-2-enone (1) and 2-hydroxy-N-(2-hydroxyphenyl)propionamide (2), were isolated from solid cultures of the phytopathogen Peronophythora litchii, along with 4-hydroxybenzyl alcohol (3) and methyl D-indole-3-lactate (4). Their structures were elucidated on the basis of spectroscopic and spectrometric data. These metabolites were not toxic to brine shrimps (LC50 > 500 microg/mL).
    Natural product communications 02/2010; 5(2):245-8. · 0.92 Impact Factor
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    ABSTRACT: Fruits of wampee [Clausena lansium (Lour.) Skeels] contain a significant amount of coumarins with many health benefits. The activity-guided separation of an ethyl acetate-soluble fraction on a polyamide column followed by silica gel column and high performance liquid chromatography (HPLC) preparation afforded a pure compound, which was identified to be 8-hydroxypsoralen based on the 1H, 13C NMR (nuclear magnetic resonance), and ESI-MS (electrospray ionisation mass spectrometric) analysis. This isolate exhibited good scavenging activities against DPPH radical and superoxide anion as well as significant reducing power. It also showed potent proliferation inhibitory activity against human hepatocellular liver carcinoma cell line (HepG2), human lung adenocarcinoma epithelial cell line (A549) and human cervical carcinoma cell line (HELA). This is the first report on the antioxidant and cytotoxic properties of C. lansium fruit extract. The food and pharmaceutical industry could be benefited by the usage of this extract containing this constituent.
    Food Chemistry 01/2010; 118(1-118):62-66. DOI:10.1016/j.foodchem.2009.04.073 · 3.26 Impact Factor
  • CHEMICAL & PHARMACEUTICAL BULLETIN 01/2010; 58(4):565-567. DOI:10.1248/cpb.58.565 · 1.38 Impact Factor
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    ABSTRACT: High pressure as a new extraction technique was carried out to extract corilagin from longan fruit pericarp. The effects of different solvents, solvent concentration and solid to liquid ratio on corilagin contents were individually determined. The optimum conditions of high pressure extraction (HPE) for corilagin content were carried out also at various pressures (200–500MPa), time (2.5–30min) and temperatures (30–90°C). The content of corilagin obtained by HPE (9.65mg/g dry matter) was higher than the ultrasonic (7.91mg/g dry matter) or conventional (2.35mg/g dry matter) extraction. Thus, application of HPE obtained higher corilagin content and required less extraction time compared to other extraction methods. The pharmaceutical and food industry can be benefited by the usage of high pressure extraction technology.
    Separation and Purification Technology 11/2009; 70(1):41-45. DOI:10.1016/j.seppur.2009.08.009 · 3.07 Impact Factor
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 10/2009; 40(43). DOI:10.1002/chin.200943203
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    ABSTRACT: Longan fruit pericarp was extracted with 50% ethanol employing high pressure (500 MPa) and conventional extraction methods. Total phenolic contents of high pressure-assisted extract of longan (HPEL) and conventional extract of longan (CEL) were 20.8 and 14.6 mg gallic acid equivalents/g dry weight, respectively. Subsequently, the antioxidant activities of these extracts were analyzed employing various antioxidant model systems including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, superoxide anion radical scavenging activity, total antioxidant capacity, and lipid peroxidation inhibitory activity. In addition, anticancer activity was also tested using HepG2, A549, and SGC 7901 cancer cell lines. HPEL showed excellent antioxidant and anticancer activities and were higher than CEL. Three phenolic compounds, namely gallic acid, corilagin, and ellagic acid, were identified and quantified by external standard methods. Compared with CEL, HPEL exhibited higher extraction effectiveness in terms of higher extraction yield, higher phenolic content, and higher antioxidant and anticancer activity with shorter extraction time.Industrial relevanceThis study was focused to evaluate the antioxidant and anticancer activity of longan fruit pericarp by high-pressure treatment. The high-pressure treatment provided a better way of utilizing longan fruit pericarp as a readily accessible source of the natural anticancer and antioxidant in food and pharmaceutical industry.
    Innovative Food Science & Emerging Technologies 10/2009; 10(4):413-419. DOI:10.1016/j.ifset.2009.04.003 · 2.25 Impact Factor
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    ABSTRACT: Five previously uncharacterised polyphenols, ethyl gallate (2), 1-β-O-galloyl-d-glucopyranose (3), methyl brevifolin carboxylate (4), brevifolin (5) and 4-O-α-l-rhamnopyranosyl-ellagic acid (8), and three previously identified polyphenols, gallic acid (1), corilagin (6) and ellagic acid (7), were isolated from longan seeds. Their structures were identified by spectroscopic and chemical methods including HRESIMS and NMR. Eight polyphenols exhibited scavenging activity towards DPPH radicals with SC50 values of 0.80–5.91 μg/ml and towards superoxide radicals with SC50 values of 1.04–7.03 μg/ml. The radical-scavenging activity of the newly characterised polyphenols was comparable to that of gallic acid, corilagin and ellagic acid.
    Food Chemistry 09/2009; 116(2-116):433-436. DOI:10.1016/j.foodchem.2009.02.059 · 3.26 Impact Factor
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    ABSTRACT: Four novel prenylflavonols, macaranones A-D (1-4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavonols having an unusual peltogynoid skeleton which is formed from a 2'-geranylflavonol by cyclization between 3-OH and C-1'' of the 2'-geranyl substituent of the flavonol. Compounds 1-4 were evaluated for the cytotoxicity against several human cancer cell lines.
    CHEMICAL & PHARMACEUTICAL BULLETIN 06/2009; 57(5):495-8. DOI:10.1248/cpb.57.495 · 1.38 Impact Factor
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    ABSTRACT: Iridoid glycosides, 2',3',6'-tri-O-acetyl-4'-O-trans-p-(O-beta-d-glucopyranosyl)coumaroyl-7-ketologanin (1), 2'-O-caffeoylloganic acid (2), 2'-O-p-hydroxybenzoylloganic acid (3), 2'-O-trans-p-coumaroylloganic acid (4), and 2'-O-cis-p-coumaroylloganic acid (5), were isolated from whole plants of Gentiana loureirii along with six known iridoids, 7-ketologanin (6), loganin (7), loganic acid (8), sweroside, boonein, and isoboonein, and three other known compounds. Their structures were elucidated by spectroscopic means and chemical correlations. The isolated iridoids were evaluated for antibacterial and antioxidant activities, but were either inactive or very weakly active.
    Phytochemistry 05/2009; 70(6):746-50. DOI:10.1016/j.phytochem.2009.03.018 · 3.35 Impact Factor
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    ABSTRACT: A new isoryanodane diterpene, 13-deoxyitol A (1), together with a known isoryanodane diterpene, itol A (2), was isolated from the methanol extract of the seeds of Itoa orientalis. Its structure was determined by spectroscopic means. Compounds 1 and 2 showed antifeedant and contact toxic activities against various insect pests.
    Fitoterapia 04/2009; 80(5):286-9. DOI:10.1016/j.fitote.2009.03.006 · 2.23 Impact Factor
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    ABSTRACT: Seven structurally related new polyoxygenated methyl cyclohexanoids, ampelomins A-G (1-7), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus. Their structures were determined by spectroscopic and chemical means. Ampelomins A (1), C (3), E (5), and G (7) exhibited weak activity against alpha-glucosidase with IC(50) values of 1.74-5.93 mM, and ampelomin A (1) showed moderate antibacterial activity with MIC(90) values ranging from 202.4 to 1015.9 microM. A plausible polyketide biogenetic pathway is postulated for these compounds.
    Journal of Natural Products 03/2009; 72(2):265-9. DOI:10.1021/np800667e · 3.95 Impact Factor
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    ABSTRACT: Postharvest browning of longan fruit results in a short life and a reduced commercial value. The experiments were conducted to separate, then purify and finally identify the polyphenol oxidase (PPO) substrates that cause longan fruit to brown. PPO and its substrates were, respectively, extracted from longan fruit pericarp tissues. The substrate for longan PPO was separated and purified using polyamide column chromatography, Sephadex LH-20 column chromatography and silica gel column chromatography, respectively. The substrate was further identified by 0.5% FeCl3 solution and enzymatic reaction with longan PPO. On the bases of UV, 1H NMR, 13C NMR, and ESI-MS data, the direct substrate for the PPO from pericarp tissues of longan fruit was identified to be (−)-epicatechin. Furthermore, the contents of (−)-epicatechin of pericarp tissues of longan fruit of two major cultivars were determined by high performance liquid chromatography (HPLC). The HPLC analysis exhibited that the contents of (−)-epicatechin of fruit pericarp of ‘Shixia’ and ‘Chuliang’ were 0.26 and 0.56 mg/g on fresh weight (FW) basis at harvest and 0.15 and 0.09 mg/g FW after 3 days of storage. The more rapid decrease in the (−)-epicatechin content of ‘Chuliang’ was due to the oxidization catalyzed by PPO, which was in agreement with the higher browning index.
    Lebensmittel-Wissenschaft und-Technologie 12/2008; 41(10):1742-1747. DOI:10.1016/j.lwt.2008.02.003 · 2.47 Impact Factor
  • Biochemical Systematics and Ecology 11/2008; 36(11):867-871. DOI:10.1016/j.bse.2008.09.004 · 1.17 Impact Factor
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    ABSTRACT: Two new sulfur-containing phenolic compounds, 7-hydroxy-5-hydroxymethyl-2H-benzo[1,4]thiazin-3-one (1) and 2,5-dihydroxy-3-methanesulfinylbenzyl alcohol (2), along with two known compounds, 3-chloro-2,5-dihydroxybenzyl alcohol (3) and 2-hydroxy-6-methylbenzoic acid (4), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus by antibacterial assay-guided fractionation. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1-3 showed structure and microbial dependent antibacterial activities.
    Bioscience Biotechnology and Biochemistry 08/2008; 72(7):1746-9. DOI:10.1271/bbb.80043 · 1.27 Impact Factor
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    ABSTRACT: Two 2-phenylbenzofurans, lespedezavirgatol (1) and lespedezavirgatal (2), and a coumestan, lespedezacoumestan (3), were isolated from the aerial parts of Lespedeza virgata, together with nine known flavonoids. Their structures were determined on the basis of spectroscopic data. The three new compounds showed strong oxygen radical absorbance capacity and potent inhibition toward lipid peroxidation in both plasma and kidney homogenate of renal failure rats.
    Journal of Natural Products 07/2008; 71(6):929-32. DOI:10.1021/np800016e · 3.95 Impact Factor
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    ABSTRACT: Longan fruits contain a significant amount of polyphenols. In the present study, polyphenols were extracted from longan pericarp tissues, and then two representative polyphenols were separated and purified by polyamide column chromatography, Sephadex LH-20 column chromatography, and silica gel column chromatography. On the basis of 1H NMR, 13C NMR, and electrospray ionization mass spectrometric (ESI-MS) data, the two compounds were identified as 4-O-methylgallic acid and (-)-epicatechin, respectively. In terms of reaction with longan polyphenol oxidase (PPO), (-)-epicatechin was further identified as the PPO substrate that caused longan fruit to brown. The results of antioxidant activity showed that 4-O-methylgallic acid had higher reducing power and 2,2-diphenyl-1-picrylhydrazyl- (DPPH-), hydroxyl radical-, and superoxide radical-scavenging activities than (-)-epicatechin.
    Journal of Agricultural and Food Chemistry 08/2007; 55(14):5864-8. DOI:10.1021/jf070839z · 3.11 Impact Factor
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    ABSTRACT: Postharvest browning of litchi fruit results in short shelf life and reduced commercial value. Experiments were conducted to separate, purify and identify polyphenol oxidase (PPO ) substrates that cause litchi fruit to brown. PPO and its substrate were extracted from the pericarp tissues of litchi fruit. The litchi PPO substrate was purified using polyamide column, silica gel column and Sephadex LH-20 column chromatography. The browning substrate was selected by a 0.5% FeCl3 solution and then identified using a partially purified litchi PPO. Analyses of ultraviolet spectrometry, nuclear magnetic resonance and electrospray ionization mass spectrometry indicated that the PPO substrate was procyanidin A2. The substrate can be oxidized to ο-quinones by litchi PPO and then form brown-colored by-products, resulting in pericarp browning of harvested litchi fruit.
    Journal of Food Biochemistry 05/2007; 31(3):300 - 313. DOI:10.1111/j.1745-4514.2007.00114.x · 0.85 Impact Factor
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    ABSTRACT: Eleven flavonoids including a new flavone glycoside, 7,3′-dihydroxy-4′-methoxyflavone-7-O-β-glucopyranoside, and a quinolizidine alkaloid, lupanine, were isolated from the seeds of two Ammopiptanthus (Leguminosae) species, Ammopiptanthus mongolicus and Ammopiptanthus nanus. 7,3′-Dihydroxy-4′-methoxyflavone and lupanine were the major constituents in the seeds of both species. The patterns of seed flavonoids presented a clear systematic relationship between the two species. The simple seed alkaloid composition was presumed to be responsible for the weak defense capability of the seeds to insect pests in both species.
    Biochemical Systematics and Ecology 05/2007; 35(5):274-280. DOI:10.1016/j.bse.2006.10.015 · 1.17 Impact Factor
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    ABSTRACT: A new carbazole alkaloid, streptoverticillin, and a new 2-azetidinone, streptoverticillinone, along with three known cyclodipeptides were isolated from the mycelial solid culture of Streptoverticillium morookaense. Their structures were elucidated by analysis of 1D and 2D NMR, mass spectra and optical rotation data. Two new compounds exhibited antifungal activity against Peronophythora litchii.
    The Journal of Antibiotics 04/2007; 60(3):179-83. DOI:10.1038/ja.2007.19 · 2.04 Impact Factor
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    ABSTRACT: Chinese water chestnut (CWC) is one of the most popular foods among Asian people due to its special taste and medical function. Experiments were conducted to test the antioxidant activity and then determine the major phenolic compound components present in CWC. CWC phenolic extract strongly inhibited linoleic acid oxidation and exhibited a dose-dependent free-radical scavenging activity against alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radicals, superoxide anions and hydroxyl radicals, which was superior to ascorbic acid and butylated hydroxytoluene (BHT), two commercial used antioxidants. Furthermore, the CWC extract was found to have a relatively higher reducing power, compared with BHT. The major phenolic compounds present in CWC tissues were extracted, purified and identified by high-performance liquid chromatograph (HPLC) as (-)-gallocatechin gallate, (-)-epicatechin gallate and (+)-catechin gallate. This study suggests that CWC tissues exhibit great potential for antioxidant activity and may be useful for their nutritional and medicinal functions.
    Molecules 02/2007; 12(4):842-52. · 2.10 Impact Factor

Publication Stats

502 Citations
183.71 Total Impact Points

Institutions

  • 2000–2015
    • Chinese Academy of Sciences
      • • South China Botanical Garden
      • • Beijing Botanical Garden
      Peping, Beijing, China
  • 2010–2013
    • Government of the People's Republic of China
      Peping, Beijing, China
  • 2011
    • Jinan University (Guangzhou, China)
      Shengcheng, Guangdong, China
  • 2007
    • Zhejiang Gongshang University
      Hang-hsien, Zhejiang Sheng, China
  • 2006
    • Anhui Agricultural University (AHAU)
      Luchow, Anhui Sheng, China