Ya-Li Zhang

Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Shi, China

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Publications (6)3.09 Total impact

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    ABSTRACT: Objective: To explore the relationship between ulcerative colitis (UC) and lung injuries by assessing their clinical manifestations and characteristics. Methods: From July 2009 to April 2012, 91 UC patients presenting to Longhua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study. According to the scores of disease activity index, the patients were divided into the mild, moderate, and severe groups. Meanwhile, the records of pulmonary symptoms, chest X-ray image, and pulmonary function were reviewed. Results: Sixty-eight (74.7%) patients had at least 1 pulmonary symptom, such as cough (38.5%), shortness of breath (27.5%), and expectoration (17.6%). And 77 (84.6%) had at least 1 ventilation abnormality. Vital capacity value was significantly lower in the severe group than that in the mild group (91.82%±10.38% vs. 98.92%±12.12%, P<0.05). Conclusions: Lung injury is a common extraintestinal complication of UC. According to the theory in Traditional Chinese Medicine that the lung and large intestine are related, both the lungs and large intestine should be treated simultaneously.
    Chinese Medical Sciences Journal 07/2015; 30(2):65-69. DOI:10.1016/S1001-9294(15)30013-4
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    Yan-Cheng Dai · Zhi-Peng Tang · Ya-Li Zhang
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    ABSTRACT: Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.
    World Journal of Gastroenterology 04/2011; 17(13):1690-3. DOI:10.3748/wjg.v17.i13.1690 · 2.37 Impact Factor
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    ABSTRACT: To observe the influence of Shenqing Recipe (SQR), a kind of Traditional Chinese Medicine, on the morphology and quantity of colonic interstitial cells of Cajal (ICC) in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis, and to investigate the possible mechanism of SQR in regulating intestinal dynamics. Sixty rats were randomly divided into normal control, model 1, model 2, mesalazine, and high-dose, and low-dose SQR groups with 10 rats in each group. TNBS (10 mg) dissolved in 50% ethanol was instilled into the lumen of the rat colon of the latter five groups to induce colitis. On the 4th day after administration of TNBS, each treatment group was administered one of the following formulations by enteroclysis gavage once a day for 7 days: 600 mg•kg⁻¹•d⁻¹ mesalazine, 2.4 g•kg⁻¹•d⁻¹ SQR, and 1.2 g•kg⁻¹•d⁻¹ SQR. Model 2 rats received normal saline solution. After 7 days colonic samples were collected. While the colonic samples of model 1 group were collected on the 3rd day after TNBS administered. Ultrastructure of ICC in the damaged colonic tissues was observed with transmission electron microscope. Expression of c-kit protein in colonic tissue was determined by immunohistochemical staining and Western blot. The ultrastructure of colonic ICC in the rat model of TNBS-induced colitis showed a severe injury, and administration of SQR or mesalazine reduced the severity of injury. Similarly, the expression of c-kit protein of TNBS-induced colitis rat model was significantly decreased compared with the normal control group (P < 0.05). Treatment with SQR or mesalazine significantly increased the expression of c-kit protein compared with the administration of control formulations (P < 0.05), especially the high-dose SQR group. SQR could alleviate and repair the injured ICC, and improve its quantity, which might be involved in regulating intestinal motility.
    Chinese Medical Sciences Journal 03/2011; 26(1):43-8. DOI:10.1016/S1001-9294(11)60018-7
  • Journal of Traditional Chinese Medicine 09/2010; 30(3):237-40. DOI:10.1016/S0254-6272(10)60049-0 · 0.72 Impact Factor
  • Chinese Medical Sciences Journal 12/2009; 24(4):248-51. DOI:10.1016/S1001-9294(10)60011-9
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    Ya-Li Zhang · Zhi-Peng Tang
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    ABSTRACT: Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion molecule that is preferentially expressed on the surface of vas- cular endothelial cells in intestinal tract and associated lymphoid tissues, and it is a major determinant of lymphocyte trafficking to the gut mucosa. The expression of MAdCAM-1 is dramatically increased in the inflammatory sites of ulcerative colitis (UC). This article reviews the molecular structure, distribution, biologi- cal function of MAdCAM-1 and its role in the pathogenesis of UC. It is also emphasized that MAdCAM-1 is a potential therapeutic target in UC.