[Show abstract][Hide abstract] ABSTRACT: To study the demographic and clinical features of infantile hemangioma in China; to learn in more detail the risk factors for developing this disease; and to identify clinical characteristics associated with complications, associated risks, and the need for systemic treatment.
A case-control study of 1832 prospectively enrolled children with hemangiomas and 1832 controls matched for age, sex, region, and hospital attending the dermatology department between 2005 and 2008.
Two large hospitals in central south China.
A total of 1832 children with hemangiomas.
Demographic and clinical presentations were summarized and compared with data from previous studies of hemangiomas. Predictive clinical factors for complications and/or treatment and potential risk factors for infantile hemangioma were analyzed by logistic regression.
The clinical features of our study patients were different from those of other race/ethnicity groups reported by previous studies with regard to the morphologic subtypes, complications, and predictors for complications and/or oral corticosteroid treatment. After adjustment, significant risk factors for hemangiomas included lower level of maternal education (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.57-0.66), mother engaged in manual labor (OR, 1.29; 95% CI, 1.12-1.48), multiple gestation (OR, 1.20; 95% CI,1.05-1.36), maternal medication use during the periconceptional period (OR, 2.08; 95% CI, 1.88-2.31), and a positive family history of hemangiomas (OR, 1.55; 95% CI, 1.40-1.72).
Besides yielding several new findings with respect to risk factors for hemangiomas, the current study also suggests that the Chinese clinical features of hemangiomas are somewhat different epidemiologically from those in the West.
Archives of dermatology 05/2011; 147(9):1049-56. DOI:10.1001/archdermatol.2011.122 · 4.79 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: To study the activation of Janus protein tyrosine kinase (JAK)/signal transducer and activator of transcription 1 (STAT1) signaling pathway and its inhibitor-signal transducer and activator of transcription-1(SOCS-1) in patients with systemic lupus erythematosus.
A total of 45 patients with active systemic lupus erythematosus (SLE) and 30 healthy controls were randomly selected. Western blot was performed to measure the expression of Stat1 protein and phospho-Stat1 protein (an activated form of Stat1 protein) in the monocytes after stimulation with recombinant high mobility group box1 (rHMGB1) at various time points. Expression of Stat1 protein in the skin or lesional skin was also detected. Phasic expressions of SOCS-1 mRNA in the monocytes after rHMGB1 stimulation were detected by real-time reverse transcription-polymerase chain reaction. SOCS-1 gene expression in the skin or lesional skin was also detected.
The expression level of Stat1 proteins in the monocytes from patients with SLE was higher than that from healthy controls (t=9.16, P<0.01) and positively correlated with SLE disease activity index (SLEDAI) (r=0.59, P<0.01). Expression of phospho-Stat1 in the monocytes from SLE patients was time-dependently upregulated after stimulation with rHMGB1 at various time points, while expression of SOCS-1 mRNA remained unchanged (all P>0.05). Expressions of phospho-Stat1 protein and SOCS-1 mRNA in the monocytes from healthy controls were increased transiently after stimulation with rHMGB1 (all P<0.05). Both expressions of phospho-Stat1 protein and SOCS-1 gene in the lesional skin from patients with SLE were upregulated compared with those in normal skin from healthy controls (all P<0.01).
There are hyperactivation of JAK-STAT1 signaling pathway and negative feedback down-regulation of SOCS-1 in patients with systemic lupus erythematosus. HMGB-1 may be partly involved in the pathogenesis of SLE by the abnormal mediating function of JAK-STAT1 signal transduction pathway.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 02/2011; 36(2):109-15. DOI:10.3969/j.issn.1672-7347.2011.02.003
[Show abstract][Hide abstract] ABSTRACT: To determine the clinical feature of lichen planus in Hunan, and to provide references for correct diagnosis and treatment.
The clinical data from 124 outpatients with lichen planus attending Dermatology Department of Xiangya Hospital, Central South University from January 2000 to April 2008 were analysed retrospectively, including data on sex, age of visit or onset, course of disease, clinical manifestation, histopathology, and so on.
In these 124 patients, male to female ratio was 1:1. Most patients were in 30-60 age group when they first visited the Out-patient Department. There were 2 onset peaks, one in 14-29 age group and the other in 40-60 age group. Most (35.5%) of the lesions were chronic localized subtypes. The limbs were the most common site to be involved, and they were also the most prevalent site for onset of lichen planus(74 cases, 59.7% ). The second common site was the trunk (29 cases, 23.4%). Fifteen patients (12.1%) had genitalia lesions, and 9 (7.3%) accompanied with oral mucosal involvement. Most of the eruptions were half-distributed (44.3%), 64 patients (51.6%) had pruritus,which ranged from mild irritation to severe intolerable itching, 56 (45.2%) had no subjective symptoms, 4 (3.2%) had spontaneous pain or tenderness, and 2 had positive family history of lichen planus. The diagnostic accordance rate was 50.8%.
Some characteristics exist in sex, age, and clinical manifestation of lichen planus in Hunan province. Systemic and/or local treatment should be taken according to the lesion morphology, localization and subtypes of lichen planus.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 11/2010; 35(11):1178-82. DOI:10.3969/j.issn.1672-7347.2010.11.011