W Dissmann

Humboldt-Universität zu Berlin, Berlín, Berlin, Germany

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Publications (53)39.49 Total impact

  • R Eisele · D Athanasiadis · W Dissmann · M Nasseri · W Thimme
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    ABSTRACT: Symptoms and signs of 18 patients with postoperative bacterial peritonitis were compared with the findings in uncomplicated postoperative cases. Their diagnostic values were examined: 1. Elevated temperature, hyperventilation, and somnolence are relevant, being indicative of bacterial peritonitis and already occurring before the typical findings on abdominal examination. 2. In those patients with peritonitis, hemodynamics, and metabolism are characterized by hyperdynamic circulation, premature arterial hypotension with dry warm skin, and lactate accumulation. 3. Laboratory data often reveal thrombocytemia, leucocytosis with shift to the left, and a relative and absolute hypophosphatemia.
    Der Chirurg 07/1978; 49(6):355-61. · 0.52 Impact Factor
  • W Thimme · H J Buschmann · W Dissmann · R Amft
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    ABSTRACT: Ten case histories of patients with lactic acidosis and biguanide therapy are presented. 6 patients received phenformin, 4 buformin. The symptomatology was characterized by somnolence or unconsciousness with hyperventilation, renal insufficiency, signs of infection occasionally with detection of gram negative rods and in later stages circulatory insufficiency with high central venous pressure. Glucose, insulin, bicarbonate, dialysis, antibiotics and katecholamines were the therapeutic measurements. It is the proposal of this communication to call attention again to the potential toxicity of biguanids which makes necessary the strict observation of contraindications.
    Medizinische Klinik 10/1976; 71(36):1429-33.
  • H J Buschmann · W Dissmann · W Thimme · J H Schäfer
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    ABSTRACT: An inquiry with Berlin hospitals on the care of patients with acute myocardial infarction revealed that only 30% were treated on wards guaranteeing optimum supervision and treatment according to their equipment and staff. The inquiry further shows which procedures have gained ground in the treatment of dysrhythmias and heart failure and in the prevention of thrombosis. An improvement of the care is to a lesser extent to be expected from the further development of costly therapeutical specialities but rather from administrative measures ensuring disease-specific admission to appropriate hospitals. This calls for authorities to attend to this task.
    MMW, Münchener medizinische Wochenschrift 03/1976; 118(7):191-6.
  • R Eisele · W Dissmann · D Kötter · M Nasseri · W Thimme
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    ABSTRACT: At the end of an abdominal operation, a Teflon catheter was inserted into the portal vein, where it remained for nine days. Thus, blood samples could be withdrawn for analyses, and pressures could be recorded. The investigations were carried out in 41 patients who had a gastric or intestinal operation and had an uncomplicated postoperative course. The pressures in the portal vein and the arterioportal oxygen content difference were constant with 7 to 8 millimeters of mercury and by 2 volume per cent, respectively, during the period of all nine postoperative days. The pressure gradient between portal and central veins was about 6 millimeters of mercury. By infusing 350 to 500 milliliters of dextran 60 on day one or two postoperatively, the cardiac output was elevated about one-third, the central venous pressure increased from 0.9 to 4.9 millimeters of mercury and the portal venous pressure increased from 7.8 to 9.7 millimeters of mercury. This means that the pressure difference between the portal and central veins diminished. Simultaneously, the oxygen content difference between the systemic and pulmonary artery decreased from 4.7 to 3.3 volume per cent and between the systemic artery and portal vein, from 1.8 to 1.3 volume per cent. By assuming a constancy of the oxygen consumption in the region of the mesenteric circulation during infusion, it can be calculated from the behavior of the arterioportal oxygen content difference that the flow increase in the portal vein nearly equals that of cardiac output. The physical transhepatic resistance decreased about 50 per cent.
    Surgery, gynecology & obstetrics 01/1976; 141(6):870-4.
  • R Eisele · W Dissmann · M Nasseri · W Thimme
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    ABSTRACT: In 24 patients (16 women, 8 men, mean age 60 years), who underwent abdominal operations and who had a uncomplicated postoperative course, a teflon-tube was inserted into the portal vein at the end of laparotomy and remained there for maximal 9 days. The mean values of the portal venous pressure as well as of the portal-central venous pressure gradient are unchanged during the period of all 9 days and are between 7,4 and 7,9 mmHg, between 5,6 and 6,9 mmHg respectively. The arterio-portal venous 0(2)-content difference shows in the mean no fluctuations and is about 2 Vol.%. On the first postoperative day the lactic and pyruvic acid concentrations in the artery and portal vein are moderately, but significantly elevated and decrease to normal values until day 7. - 9.
    Research in Experimental Medicine 01/1976; 166(2):131-45.
  • R. Eisele · W. Dissmann · M. Nasseri · W. Thimme
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    ABSTRACT: Bei 24 Patienten (16 Frauen, 8 Mnner, mittleres Alter 60 Jahre), die sich einer Bauchoperation unterziehen muten und deren postoperativer Verlauf klinisch unkompliziert war, wurde am Ende der Laparotomie ein Teflon-Katheter in die Pfortader implantiert und maximal 9 Tage belassen.Der Pfortaderdruck sowie der porto-zentralvense Druckgradient bleiben ber den gesamten Zeitraum im Mittel unverndert und betragen zwischen 7,4 und 7,9 mmHg bzw. zwischen 5,6 und 6,9 mmHg.Die arterio-portale O2-Gehaltsdifferenz zeigt im Mittel keine Schwankungen und liegt um 2 Vol.%.Der Lactat- und Pyruvatgehalt ist am 1. postoperativen Tag in Arterie und Pfortader mig, jedoch signifikant erhht, um bis zum 7. bis 9. Tag wieder auf Normalwere abzufallen.In 24 patients (16 women, 8 men, mean age 60 years), who underwent abdominal operations and who had a uncomplicated postoperative course, a teflontube was inserted into the portal vein at the end of laparotomy and remained there for maximal 9 days.The mean values of the portal venous pressure as well as of the portalcentral venous pressure gradient are unchanged during the period of all 9 days and are between 7,4 and 7,9 mmHg, between 5,6 and 6,9 mmHg respectively.The arterio-portal venous O2-content difference shows in the mean no fluctuations and is about 2 Vol.%.On the first postoperative day the lactic and pyruvic acid concentrations in the artery and portal vein are moderately, but significantly elevated and decrease to normal values until day 7. – 9.
    Research in Experimental Medicine 05/1975; 166(2):131-145. DOI:10.1007/BF01851180
  • W Thimme · H J Buschmann · W Dissmann
    Lebensversicherungs Medizin 04/1975; 27(2):41-5.
  • W Dissmann · W Thimme · H J Buschmann · G Goeckenjan
    DMW - Deutsche Medizinische Wochenschrift 11/1972; 97(43):1672-3. · 0.55 Impact Factor
  • W Thimme · W Dissmann · H J Buschmann · J Daugs · R Eisele · B Ramdohr
    Klinische Wochenschrift 08/1972; 50(14):674-88.
  • W Thimme · W Dissmann · R Eisele · W R Bruhn
    Zeitschrift für praktische Anästhesie, Wiederbelebung und Intensivtherapie 07/1972; 7(3):140-60.
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    ABSTRACT: Das klinische Bild von 33 Patienten mit bedrohlichen Allgemeininfektionen ist gekennzeichnet durch mehrere der folgenden Symptome: Tachykardie, Hypotensionen, Strung der Bewutseinslage, Tachypnoe und Oligurie bis Anurie. Die charakteristischen hmodynamischen Befunde sind Erniedrigung des peripheren Widerstandes bei normalem oder sogar erhhtem Herzzeitvolumen, mehr oder weniger ausgeprgter Hypotension und normaler oder erniedrigter arteriovenser Sauerstoffgehaltsdifferenz. Trotz normalem Sauerstoffangebot ist die arterielle Milchsure-Konzentration hufig erhht. Zur Klrung der Frage, ob dieser Befund auf eine toxinbedingte Strung des oxydativen Glucoseabbaus zurckzufhren ist, wird der Sauerstoffverbrauch von Rattenlebermitochondrien nach Gabe von Coli-Endotoxinen in vivo und in vitro bestimmt. Dabei wird eine Lockerung der Kopplung von Atmung und Phophorilierung festgestellt. — In der Frhphase von bedrohlichen Infektionen wird hufig eine respiratorische Alkalose gefunden. Eine Lactatacidose im Liquor cerebrospinalis ist nicht die Ursache der Hyperventilation, eine gemessen an den metabolischen Bedrfnissen erniedrigte Gehirndurchblutung nicht die Ursache der Somnolenz. — Die Bedrohung der Patienten ist durch Strungen unterschiedlicher Organfunktionen gegeben. Die entscheidenden therapeutischen Manahmen bestehen in chirurgischer Sanierung des Infektionsherdes und breitwirksamer antibiotischer Therapie.The clinical picture of 33 patients with life-threatening generalized infections is characterized by some of the following symptoms: tachycardia, hypotension, disturbances of mental state, tachypnea, and oliguria or anurai. The haemodynamic findings are lowered peripheral resistance, normal or increased cardiac output, more or less pronounced hypotension and normal or decreased AVDO2. In spite of normal oxygen supply, the arterial lactate concentration is often elevated. In order to evaluate the causes, the oxygen consumption of rat liver mitochondria was measured before and after application of Coli-endotoxinin vivo andin vitro. A decreased coupling of respiration and phosphorylation was found. — During the early phase of life-threatening infections a respiratory alkalosis can often be seen. Lactic acidosis ofliquor cerebrospinalis is not the cause of this hypoventilation, nor is diminished cerebral blood flow the cause of somnolence. The patients are threatened by impaired function of various organs. The decisive therapeutic measure are surgery and/or broad spectrum antibiotic therapy.
    Journal of Molecular Medicine 06/1972; 50(14):674-688. DOI:10.1007/BF01495526 · 4.74 Impact Factor
  • W Thimme · H J Buschmann · W Dissmann · R Pust · B Ramdohr
    Zeitschrift für Kreislaufforschung 11/1971; 60(10):900-10.
  • Zeitschrift für Kreislaufforschung 06/1971; 60(5):375-97.
  • R Keller · W Thimme · W Dissmann · H J Buschmann · K Dross · J Daugs
    Schweizerische medizinische Wochenschrift 05/1971; 101(14):511-5. · 1.68 Impact Factor
  • Klinische Wochenschrift 06/1970; 48(10):591-7.
  • B. Ramdohr · W. Dissmann · H. J. Buschmann
    Klinische Wochenschrift 05/1970; 48(10):591-597. DOI:10.1007/BF01485392
  • W Thimme · W Dissmann · R Eisele
    Die Medizinische Welt 04/1970; 12:477-8 passim.
  • W Dissmann · W Thimme
    Der Internist 12/1969; 10(11):408-11. · 0.27 Impact Factor
  • R. Eisele · W. Dissmann · M. Nasseri · W. Thimme · E. S. Bücherl
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    ABSTRACT: Summary 1.Considerable hyperventilation occurs with inflammatory abdominal diseases. Respiratory alkalosis is characteristic for bacterial inflammation whereas metabolic acidosis is characteristic for infarction of the mesenteric artery. Gastric perforation does not produce a definite change of the acid-base-balance.2.A direct effect of the endotoxin on the respiratory centre must be regarded as the cause of this hyperventilation.3.The increase of lactate and pyruvate which is frequently associated with bacterial abdominal inflammation is not a result of hyperventilation. Rather than that, it is a result of an abnormal carbohydrate metabolism produced by the action of the endotoxin.
    Langenbecks Archiv fü Chirurgie 12/1969; 325(1):1174-1179. DOI:10.1007/BF01256093