Wei Xiao

East China University of Science and Technology, Shanghai, Shanghai Shi, China

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Publications (1)1.96 Total impact

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    ABSTRACT: Cell-penetrating peptides can carry a variety of biologically active molecules into cells. Here we have identified a novel CPP derived from the C-terminus of human extracellular superoxide dismutase (hC-SOD3) which was shown to be located throughout in the cytoplasm and nucleus by fluorescence microscopy investigation. Furthermore, when apoptin fused to hC-SOD3, it was translocated efficiently into HeLa cells resulting in antitumor activities. This study shows that hC-SOD3 has the potential to penetrate and translocate cargo molecules into cells and has no cytotoxicity at effective concentration.
    Molecular Biology Reports 11/2010; 38(4):2649-56. DOI:10.1007/s11033-010-0406-6 · 1.96 Impact Factor

Publication Stats

6 Citations
1.96 Total Impact Points

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Institutions

  • 2010
    • East China University of Science and Technology
      • School of Pharmacy
      Shanghai, Shanghai Shi, China