Uday Khopkar

KEM Hospital, Poona, Maharashtra, India

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Publications (131)126.22 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Streptococcus pyogenes (group A streptococcus; GAS) is an etiological agent for pharyngitis, pyoderma, and invasive infections in humans. Pharyngitis and pyoderma may lead to serious immune sequelae such as rheumatic heart disease and post-streptococcal glomerulonephritis (PSGN). Streptococcal Inhibitor of Complement (SIC) and its orthologue, distantly related to SIC (DRS), are virulence factors expressed by only four of more than 100 M types of GAS. These four types (M1, M57, M12 and M55) are among the M types, which are associated with PSGN. In several populations PSGN has been shown to be a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Previous studies showed SIC or DRS antibody-prevalence was associated with PSGN, and seroprevalence of SIC antibodies is significantly high among CKD and ESRD patients in Mumbai. Streptococcal isolates recovered from GAS pyoderma cases were typed. Seropositivity for SIC and DRS antibodies in subjects with pyoderma, PSGN pediatric cases, age matched healthy controls and non-GAS pyoderma cases were determined. We confirm in this study an association between seroprevalence to SIC and DRS antibodies, and PSGN in Mumbai population despite low point prevalence of M1, M12, M55 and M57. In addition we extended the study to GAS-pyoderma and non-GAS pyoderma cases. To our surprise, we found a positive association between the seroprevalence to SIC and DRS antibodies, and GAS-pyoderma owing to infection with diverse M types. The mechanism of increased predisposition to pyoderma owing to infection by diverse GAS among SIC or DRS antibody-positive population is not clear. Nonetheless, our findings could be explained by a phenomenon akin to antibody-dependent enhancement (ADE). This is the first report showing a small number of GAS M types conferring predisposition to pyoderma by diverse types. Implications of this ADE-like phenomenon are discussed in the light of evolutionary advantage to GAS, vaccine design and control of renal diseases.
    BMC Infectious Diseases 12/2015; 15(1):857. DOI:10.1186/s12879-015-0857-4 · 2.56 Impact Factor
  • Bhushan Madke, Uday Khopkar
    05/2015; 6(3):223. DOI:10.4103/2229-5178.156429
  • Indian journal of dermatology, venereology and leprology 04/2015; DOI:10.4103/0378-6323.155561 · 1.33 Impact Factor
  • Kinjal D Rambhia, Atul M Dongre, Uday S Khopkar
    Indian journal of dermatology, venereology and leprology 03/2015; 81(3). DOI:10.4103/0378-6323.152748 · 1.33 Impact Factor
  • Indian Journal of Dermatology Venereology and Leprology 03/2015; 81(2):213-214. DOI:10.4103/0378-6323.152308 · 1.33 Impact Factor
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    ABSTRACT: Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder characterized by cutaneous and ocular photosensitivity and an increased risk of developing cutaneous neoplasms. Progressive neurological abnormalities develop in a quarter of XP patients. To study the clinical profile and perform a mutation analysis in Indian patients with xeroderma pigmentosum. Ten families with 13 patients with XP were referred to our clinic over 2 years. The genes XPA, XPB and XPC were sequentially analyzed till a pathogenic mutation was identified. Homozygous mutations in the XPA gene were seen in patients with moderate to severe mental retardation (6/10 families) but not in those without neurological features. Two unrelated families with a common family name and belonging to the same community from Maharashtra were found to have an identical mutation in the XPA gene, namely c.335_338delTTATinsCATAAGAAA (p.F112SfsX2). Testing of the XPC gene in two families with four affected children led to the identification of the novel mutations c.1243C>T or p.R415X and c.1677C>A or p.Y559X. In two families, mutations could not be identified in XPA, XPB and XPC genes. The sample size is small. Indian patients who have neurological abnormalities associated with XP should be screened for mutations in the XPA gene.
    Indian Journal of Dermatology Venereology and Leprology 01/2015; 81(1):16-22. DOI:10.4103/0378-6323.148559 · 1.33 Impact Factor
  • Indian Journal of Dermatology Venereology and Leprology 11/2014; 80(6):577-8. DOI:10.4103/0378-6323.144223 · 1.33 Impact Factor
  • Sarvesh S Thatte, Uday S Khopkar
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    ABSTRACT: Early lesions of vitiligo can be confused with various other causes of hypopigmentation and depigmentation. Few workers have utilized dermoscopy for the diagnosis of evolving lesions of vitiligo.
    Indian Journal of Dermatology Venereology and Leprology 11/2014; 80(6):505-8. DOI:10.4103/0378-6323.144144 · 1.33 Impact Factor
  • Indian Journal of Dermatology Venereology and Leprology 09/2014; 80(5):465-7. DOI:10.4103/0378-6323.140321 · 1.33 Impact Factor
  • Tulika A Yadav, Atul M Dongre, Uday S Khopkar
    Indian Journal of Dermatology Venereology and Leprology 09/2014; 80(5):454-6. DOI:10.4103/0378-6323.140310 · 1.33 Impact Factor
  • Indian Journal of Dermatology Venereology and Leprology 09/2014; 80(5):432-47. DOI:10.4103/0378-6323.140304 · 1.33 Impact Factor
  • Indian Journal of Dermatology Venereology and Leprology 09/2014; 80(5):483. DOI:10.4103/0378-6323.140351 · 1.33 Impact Factor
  • Indian Journal of Dermatology Venereology and Leprology 07/2014; 80(4):342-3. DOI:10.4103/0378-6323.136912 · 1.33 Impact Factor
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    ABSTRACT: Chanarin-Dorfman syndrome (CDS) is a multisystem, autosomal recessive genetic disorder characterized by congenital non-bullous ichthyosiform erythroderma with accumulation of lipid droplets in granulocytes and basal keratinocytes. An 18-month-old female child presented with typical dermatological features of CDS. She was born as a collodion baby. Liver biopsy showed micronodular cirrhosis along with macrovesicular hepatic steatosis. Sequencing of all exons and exon-intron boundaries of the ABHD5 gene showed that the patient was homozygous for a novel mutation g.24947delG (c.773 + 1delG) in intron 5. This is the first Indian child with mutation proven CDS.
    Journal of Postgraduate Medicine 07/2014; 60(3):332-334. DOI:10.4103/0022-3859.138826 · 0.97 Impact Factor
  • Rameshwar Gutte, Uday Khopkar
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    ABSTRACT: Palmoplantar lesions in lichen planus (LP) are uncommon. In such cases, diagnosis is usually missed. This study was conducted to document various clinical and histopathological features of palmoplantar LP.
    Indian Journal of Dermatology 07/2014; 59(4):343-7. DOI:10.4103/0019-5154.135477
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    ABSTRACT: Background: Rituximab, a monoclonal anti-CD20 antibody, has been used with encouraging results in pemphigus. We describe herein refractory cases of pemphigus vulgaris (n = 23) and pemphigus foliaceus (n = 1) treated with rituximab in addition to steroids and immunosuppressants. Aims: To assess the response to treatment, the duration of clinical remission, serology of the response and adverse effects of rituximab in pemphigus patients. Methods: We recorded observations of 24 patients with pemphigus having either refractory disease in spite of high dose of steroids and immunosuppressants, corticosteroid-dependent disease, strong contraindications to corticosteroids, or severe disease. The patients were treated with infusions of one injection per week for three consecutive weeks of 375 mg of rituximab per m 2 of body-surface area. One similar infusion was repeated after 3 months of 3 rd dose. We observed the clinical outcome after 6 months of 3 rd dose of rituximab and looked for complete healing of cutaneous and mucosal lesions (complete remission). Observations: After follow-up of 7-24 months, five patients showed only partial improvement while 19 of 24 patients had a complete remission 3 months after rituximab. Of these 19 patients, 12 patients achieved complete remission and are off all systemic therapy, and the rest are continuing with no or low dose of steroids with immunosuppressants. Two patients relapsed after initial improvement; one was given moderate dose of oral steroids and immunosuppressant and the other was given repeat single dose of rituximab to control relapse. Conclusion: Rituximab is able to induce a prolonged clinical remission in pemphigus after a single course of four infusions. The high cost and limited knowledge of long term adverse effects are limitations to the use of this biologic agent.
    Indian Journal of Dermatology Venereology and Leprology 07/2014; 80(4):300-5. DOI:10.4103/0378-6323.136832 · 1.33 Impact Factor
  • Journal of the American Academy of Dermatology 06/2014; 70(6):e125-6. DOI:10.1016/j.jaad.2013.12.026 · 5.00 Impact Factor
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    ABSTRACT: Epidermal growth factor receptor (EGFR) inhibitor therapy has become the standard treatment for non-small cell lung cancer and head neck malignancy. This class of drug comprises EGFR inhibitors (erlotinib and gefitinib) and monoclonal antibody (cetuximab). Use of this class of drugs has been associated frequently with dermatological side effects termed as PRIDE complex-Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, Dryness due to EGFR inhibitors. We hereby report the cutaneous side effects of EGFR inhibitor therapy in 15 patients of lung and head/neck cancer. The major clinical findings being acneiform eruption and severe xerosis of skin. Management of these dermatological adverse effects rarely requires discontinuation of targeted therapy and can be managed symptomatically.
    Indian Journal of Dermatology 05/2014; 59(3):271-4. DOI:10.4103/0019-5154.131398
  • Clinical and Experimental Dermatology 05/2014; 39(5). DOI:10.1111/ced.12338 · 1.23 Impact Factor

Publication Stats

281 Citations
126.22 Total Impact Points

Institutions

  • 2006–2015
    • KEM Hospital
      Poona, Maharashtra, India
    • King Edward Memorial Hospital
      Mumbai, Maharashtra, India
  • 2011
    • Government Dental College & Hospital, Aurangabad
      Aurangâbâd, Mahārāshtra, India
  • 2007
    • Adichunchanagiri Institute of Medical Sciences
      • Department of Dermatology
      Mandya, State of Karnataka, India