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12/2003: pages 405-412;
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Advances in experimental medicine and biology 02/2003; 528:405-12. · 1.09 Impact Factor
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J Igari,
T Oguri,
Y Tachibana,
N Misawa,
A Nakamura,
M Shitara, S Umezu,
Y Nakamura,
S Tazawa,
M Shimoura,
K Ugajin,
T Mori,
J Shimada,
M Kaku,
M Murase,
Y Hirakata,
J Matsuda
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ABSTRACT: The purpose of our investigation was to monitor current trends in the susceptibility patterns of clinical bacterial isolates to roxithromycin (RXM). We measured the MICs of macrolide antibiotics, such as RXM, erythromycin (EM), clarithromycin (CAM), rokitamycin (RKM) and midecamycin (MDM), and other classes of antibacterial compounds against various clinical isolates at seven institutions between October and December in 1994 and 1995. RXM had excellent antibacterial activities for S. pyogenes, S. agalactiae, M. (B.) catarrhalis and methicillin sensitive S. aureus. Against methicillin sensitive S. epidermidis, RXM activity was fairly good but about 20% of the strains had MIC > or = 128 micrograms/ml. The activity against S. pneumoniae was not so potent and similar to activities of EM, CAM, MDM, and clindamycin. The vast majority of methicillin resistant S. aureus and S. epidermidis were also resistant to macrolide antibiotics and other classes of compounds tested. In conclusion, RXM is an unique macrolide antibiotic by retaining potent activity against S. pyogenes, S. agalactiae, S. aureus except MRSA, M. (B.) catarrhalis and M. pneumoniae.
The Japanese journal of antibiotics 08/1997; 50(7):640-9.
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ABSTRACT: The purpose of this report is to evaluate a test kit based on the High Density Composite Particle Agglutination Test Method (HDPA method, Newly developed by Tokuyama Soda Co., Ltd). Diagnosis of Mycoplasmosis has been done with clinical symptoms, breast x-ray examination, serum anti-M. pneumoniae antibody detection and bacteriological test result. Recently, we had the chance to use this HDPA method (IMMUNOTICLES MYCO) and compared the results with bacteriological test, complement fixation method (CF) and particle agglutination method (PA) using the cases of seventy-three (73) lower respiratory infected patients. The evaluation outcomes (positive rate, sensitivities and specificities) comparing with the conventional methods based on the clinical cultured results and clinical diagnostic results respectively are shown as follows. 1) The evaluation outcomes based on the cultured results. Forty-one (41) cases of 73 samples, we could isolate the M. pneumoniae (56.2%). a) The HDPA method is correlated with CF (r = 0.885, n = 73) and PA (r = 0.764, n = 73) respectively. b) The positive rate of HDPA, PA and CF are 45.2%, 31.5% and 20.5% respectively. 2) The evaluation outcomes based on the clinical diagnosis. a) The sensitivity of the HDPA method is 66.0% and this one is much higher than the one of CF and PA. b) The specificity of the HDPA method is 92.3%. c) The positive rate of the HDPA method is higher than the one of PA and CF even though the assay was done within seven-days. In conclusion, the HDPA method is a very sophisticated method for diagnosis of M. pneumoniae and able to be substituted to any other conventional methods.
Rinsho byori. The Japanese journal of clinical pathology 07/1990; 38(6):683-7.
