-
Todd Blodgett
[show abstract]
[hide abstract]
ABSTRACT: The incorporation of positron emission tomography-computed tomography (PET-CT) into oncological imaging has expanded rapidly since the hybrid scanners were introduced approximately 10 years ago. PET-CT is becoming the standard of practice for the imaging diagnosis and staging of most cancers. Since its introduction, hardware-registered PET and CT images produced by a PET-CT scan were recognized as valuable not only for detection, staging and restaging applications but also for optimizing radiation treatment planning. Even before the introduction of PET-CT, the value of metabolic imaging with the use of FDG PET was recognized as a potentially powerful means of assessing response to various therapies, particularly chemotherapy regimens. To better understand the optimal use of PET-CT in radiation therapy planning and the role of PET-CT in assessing response to therapy, we invited experts from various disciplines to participate in focus group meetings that took place in 2009 and 2010. The Symposia focused on the use of PET-CT imaging in radiation therapy planning (2009) and the use of PET-CT in therapy response assessment (2010). This article will summarize areas of consensus reached by the group regarding many of the discussion topics. The consensus summaries covered in this article are meant to provide direction for future discussions on how to improve the application of this hybrid modality to optimize patient care.
Seminars in Ultrasound CT and MRI 12/2010; 31(6):506-15. · 1.24 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Patients with autoimmune conditions develop lymphoproliferative disorders (LPDs) at a higher frequency than normal both in association with and independent of Methotrexate (MTX). We describe a case of MTX-associated lymphoma in a patient with psoriasis on long-standing MTX. The case is notable for the initial tumor burden, the dramatic disappearance of the PET-CT findings on discontinuation of MTX, and the subsequent early regrowth of disease. Our case report is illustrative of an MTX-related NHL in an autoimmune patient. Conclusion. Withdrawal of MTX in a patient with lymphoma is reasonable before initiating chemotherapy, but observation for early regrowth of disease is necessary.
Case Reports in Medicine 01/2009; 2009:469343.
-
Todd Blodgett
[show abstract]
[hide abstract]
ABSTRACT: Positron emission tomography-computed tomography (PET-CT) using the glucose metabolism tracer 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) has become a widespread and preferred imaging modality for evaluating most cancers. Since commercial PET-CT scanners became available in 2001, there has been rapid dissemination of this hybrid imaging modality and PET-CT scanners have largely replaced stand-alone PET scanners. How PET-CT scans are performed and applied to cancer management has varied considerably, in part reflecting the varied background of the practice settings and training experience of the physicians performing and interpreting the PET-CT studies. Combined PET/CT with FDG has become the gold standard in oncologic imaging by accurately defining anatomy and function of many tumors. From April 2-4, 2008, a focus group composed of physicians and technologists from different practice settings and training backgrounds entitled "Best Practices in PET/CT Symposium" was held in Sonoma, California. The symposium focused on optimization of PET-CT protocols but also included other pertinent topics related to PET-CT imaging in oncology. This article summarizes areas of consensus reached by the group regarding many of the discussion topics. The summary consensus covered in this article is meant to provide direction for future discussions on how to improve the application of this hybrid modality to patient care.
Seminars in Ultrasound CT and MRI 09/2008; 29(4):236-41. · 1.24 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: In patients with oral head and neck cancer, the presence of metallic dental implants produces streak artifacts in the CT images. These artifacts negate the utility of CT for the spatial localization of PET findings and may propagate through the CT-based attenuation correction into the PET images. In this study, we evaluated the efficacy of an algorithm that reduces metallic artifacts in CT images and the impact of this approach on the quantification of PET images.
Fifty-one patients with and 9 without dental implants underwent a PET/CT study. CT images through the patient's dental implants were reconstructed using both standard CT reconstruction and an algorithm that reduces metallic artifacts. Attenuation correction factors were calculated from both sets of CT images and applied to the PET data. The CT images were evaluated for any reduction of the artifacts. The PET images were assessed for any quantitative change introduced by metallic artifact reduction.
For each reconstruction, 2 regions of interest were defined in areas where the standard CT reconstruction overestimated the Hounsfield units (HU), 2 were defined in underestimated areas, and 1 was defined in a region unaffected by the artifacts. The 5 regions of interest were transferred to the other 3 reconstructions. Mean HU or mean Bq/cm(3) were obtained for all regions. In the CT reconstructions, metallic artifact reduction decreased the overestimated HUs by approximately 60% and increased the underestimated HUs by approximately 90%. There was no change in quantification in the PET images between the 2 algorithms (Spearman coefficient of rank correlation, 0.99). Although the distribution of attenuation (HU) changed considerably in the CT images, the distribution of activity did not change in the PET images.
Our study demonstrated that the algorithm can enhance the structural and spatial content of CT images in the presence of metallic artifacts. The CT artifacts do not propagate through the CT-based attenuation correction into the PET images, confirming the robustness of CT-based attenuation correction in the presence of metallic artifacts. The study also demonstrated that considerable changes in CT images do not change the PET images.
Journal of Nuclear Medicine 08/2008; 49(7):1047-52. · 6.38 Impact Factor
-
American Journal of Roentgenology 11/2005; 185(4):1057-9. · 2.78 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: We performed a retrospective study of 47 patients to ascertain the ability of combined positron-emission tomography and computed tomography (PET/CT) to localize recurrent head and neck cancer. When clinically warranted, biopsies were performed in an attempt to obtain pathologic confirmation of the PET/CT findings. Of the 47 patients, 33 exhibited PET/CT findings consistent with recurrent cancer. Of the 33 patients, 25 underwent either biopsy or surgical excision of disease in an attempt to obtain a pathologic confirmation. Biopsy analysis confirmed the PET/CT findings in 22 of these patients; in the remaining 3 patients, pathologic findings were inconsistent with the PET/CT diagnosis. Based on the subset of 25 patients who underwent pathologic testing, the sensitivity of combined PET/CT was 95% and the specificity was 60%. We conclude that combined PET/CT imaging is a valuable tool for localizing tumor recurrence in patients with head and neck cancer.
Ear, nose, & throat journal 03/2005; 84(2):104, 106, 108-10. · 0.66 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: To reduce potential mis-registration from differences in the breathing pattern between two complementary PET and CT data sets, patients are generally allowed to breathe quietly during a dual-modality scan using a combined PET/CT tomograph. Frequently, however, local mis-registration between the CT and the PET is observed. We have evaluated the appearance, magnitude, and frequency of respiration-induced artefacts in CT images of dual-modality PET/CT studies of 62 patients. Combined PET/CT scans during normal respiration were acquired in 43 subjects using single- or dual-slice CT. Nineteen patients were scanned with a special breathing protocol (limited breath-hold technique) on a single-slice PET/CT tomograph. All subjects were injected with approximately 370 MBq of FDG, and PET/CT scanning commenced 1 h post injection. The CT images were reconstructed and, after appropriate scaling, used for on-line attenuation correction of the PET emission data. We found that respiration artefacts can occur in the majority of cases if no respiration protocol is used. When applying the limited breath-hold technique, the frequency of severe artefacts in the area of the diaphragm was reduced by half, and the spatial extent of respiration-induced artefacts was reduced by at least 40% compared with the acquisition protocols without any breathing instructions. In conclusion, special breathing protocols are effective and should be used for CT scans as part of combined imaging protocols using a dual-modality PET/CT tomograph. The results of this study can also be applied to multi-slice CT to potentially reduce further breathing artefacts in PET/CT imaging and to improve overall image quality.
European journal of nuclear medicine and molecular imaging 05/2003; 30(4):588-96. · 4.99 Impact Factor
