T M Cardoso

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Publications (2)5.2 Total impact

  • Article: IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection.
    R Novoa, O Bacellar, M Nascimento, T M Cardoso, R Ramasawmy, W N Oliveira, A Schriefer, E M Carvalho
    [show abstract] [hide abstract]
    ABSTRACT: Cutaneous leishmaniasis (CL) is characterized by high production of pro-inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but do not develop disease. We evaluated whether the downregulation of inflammatory response in SC is mediated by IL-10 and IL-27 and whether IL-17 is associated with control of infection. Participants include SC individuals, patients with CL and healthy subjects. Cytokines protein and mRNA were detected by ELISA and real-time PCR. IFN-γ and TNF-α levels were higher in CL than in SC group. The IL-10 levels and mRNA for IL-10 were similar in both SC and CL. mRNA for IL-27 was increased in cells from SC after stimulation with L. braziliensis antigen. There was a tendency for increased levels of IL-17 in SC compared to CL. The weak type 1 immune response observed in SC L. braziliensis infection is not because of the regulatory effects of IL-10 and IL-27. The control of Leishmania infection may be mediated by innate immune response with participation of IL-17. The results from this pilot study warrant further larger studies to investigate the potential contributions of IL-17 and IL-27 to the control of L. braziliensis infection.
    Parasite Immunology 02/2011; 33(2):132-6. · 2.60 Impact Factor
  • Article: IL‐17 and Regulatory Cytokines (IL‐10 and IL‐27) in L. braziliensis Infection
    R. NOVOA, O. BACELLAR, M. NASCIMENTO, T. M. CARDOSO, R. RAMASAWMY, W. N. OLIVEIRA, A. SCHRIEFER, E. M. CARVALHO
    [show abstract] [hide abstract]
    ABSTRACT: Cutaneous leishmaniasis (CL) is characterized by high production of pro-inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but do not develop disease. We evaluated whether the downregulation of inflammatory response in SC is mediated by IL-10 and IL-27 and whether IL-17 is associated with control of infection. Participants include SC individuals, patients with CL and healthy subjects. Cytokines protein and mRNA were detected by ELISA and real-time PCR. IFN-γ and TNF-α levels were higher in CL than in SC group. The IL-10 levels and mRNA for IL-10 were similar in both SC and CL. mRNA for IL-27 was increased in cells from SC after stimulation with L. braziliensis antigen. There was a tendency for increased levels of IL-17 in SC compared to CL. The weak type 1 immune response observed in SC L. braziliensis infection is not because of the regulatory effects of IL-10 and IL-27. The control of Leishmania infection may be mediated by innate immune response with participation of IL-17. The results from this pilot study warrant further larger studies to investigate the potential contributions of IL-17 and IL-27 to the control of L. braziliensis infection.
    Parasite Immunology 01/2011; 33(2):132 - 136. · 2.60 Impact Factor

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