Susan Knowles

University of Georgia, Athens, GA, United States

Are you Susan Knowles?

Claim your profile

Publications (6)7.53 Total impact

  • Journal of the American Veterinary Medical Association 11/2012; 241(9):1159-61. · 1.72 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: During a 4 mo epizootic, 100% of 152 lined seahorses Hippocampus erectus in 3 separate groups died while in quarantine following shipment to a public aquarium. Twelve animals with skin depigmentation and ulceration were received by the Aquatic Pathology Service, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA, for diagnostic evaluation. Microscopically, lesions in 11 seahorses included multifocal epithelial necrosis and ulceration associated with 2 to 7 µm diameter, branching, septate fungal hyphae, typically accompanied by deeper infiltration into underlying skeletal muscle. Angioinvasion, with vascular thrombosis and tissue infarction, was a prominent feature in multiple animals. Fungal invasion of one or more internal organs was observed in 4 animals. Hyphae appeared to course freely through tissues and elicited little or no inflammatory response. Fusariosis has been reported sporadically in fish and other aquatic organisms, but identification has often been limited to the genus level based solely on morphologic features. Morphologic characteristics of the fungus isolated from this case were consistent with the Fusarium solani species complex (FSSC), which includes over 50 members that can only be identified definitively using DNA sequence data. A 3-locus typing scheme identified the isolate as a distinct species/haplotype, designated FSSC 12-a, belonging to a specific lineage that appears adapted to aquatic environments and disease in marine animals. Empirical treatment with itraconazole failed to stop mortalities, and subsequent in vitro antifungal susceptibility data explained a lack of clinical efficacy for this agent. Effective treatment in human medicine has similarly been limited by poor susceptibility to several classes of antifungal compounds.
    Diseases of Aquatic Organisms 10/2012; 101(1):23-31. · 1.73 Impact Factor
  • Journal of the American Veterinary Medical Association 12/2010; 237(11):1257-9. · 1.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A 7-year-old spayed female domestic shorthair feline presented with tachycardia and was later euthanized due to a declining condition. On gross examination, the thoracic cavity contained an expansile, multiloculated mass that displaced the lungs dorsocaudally. The mass, within the pericardial sac, compressed adjacent myocardium. Cut surface revealed variably sized, fluid-filled spaces with multiple foci of hemorrhage and necrosis. Histologically, the mass was composed of solid foci of polygonal cells admixed with colloid-containing follicles. Immunohistochemical staining for thyroglobulin was positive, and staining for calcitonin was negative. Grossly, thyroid glands were normal, and serum thyroxine was within reference intervals.
    Journal of veterinary diagnostic investigation: official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 11/2010; 22(6):1010-3. · 1.18 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: An 11-year-old Oldenburg mare presented with a 3-month history of weight loss and swelling of the posterior right mandible. Physical examination and radiographs showed a soft-tissue mass in the right mandible with foci of mineralization, periosteal proliferation, and a retained molar. The tumor increased in size over several weeks, and the mare was euthanized. On necropsy, a 24 cm × 15 cm × 15 cm firm, white mass had obliterated the posterior right mandible. The mass was multinodular with discrete clusters of blood-filled cystic spaces. Histologically, the mass was composed of neoplastic odontogenic epithelium and pulpal mesenchyme with an accumulation of eosinophilic material resembling dentin or enamel. Microscopic and immunohistochemical staining features of the neoplasm were most consistent with an ameloblastic fibro-odontoma.
    Journal of veterinary diagnostic investigation: official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 11/2010; 22(6):987-90. · 1.18 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: History A 3.5-year-old spayed female Blanc de Hotot rabbit was referred to the University of Georgia Small Animal Teaching Hospital because of anorexia and lethargy of 1 week' s duration, dyspnea of 3 days' duration, and a possible thoracic mass. Clinical and Gross Findings At the referral evaluation, the rabbit was dyspneic with slightly cyanotic mucous membranes. Via auscul-tation, increased bronchovesicular sounds, which were more pronounced on the left side, were audible. Tho-racic radiography revealed pleural effusion and a mass that was obscuring the normal architecture of the lungs primarily on the left side. Cytologic examination of an ultrasound-guided fine-needle aspirate of the thoracic mass revealed numerous, variably sized clusters of well-differentiated epithelial cells that were often associated with abundant, brightly eosinophilic, amorphous to fi-brillar material (Figure 1). Individual cells were round This report was submitted by Yandace K. Brown,