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ABSTRACT: Thiol compounds such as glutathione, homocysteine, and cysteinyl-glycine are the natural reservoir of reductive capacity of
the cells. Chronic renal failure is accompanied by disturbances in redox status of plasma thiols. The aim of the present study
was to compare the changes in concentrations of different forms of thiols in plasma of terminal renal failure patients, nondialyzed
and on peritoneal dialysis. Total concentrations of different redox forms of thiols were determined by high performance liquid
chromatography. We observed that total concentration of glutathione in terminal renal failure patients decreased and total
concentration of the remaining thiols in these patients significantly increased. Continuous ambulatory peritoneal dialysis
had the following features in comparison with nondialyzed patients: (1) glutathione and cysteine concentration was restored
and (2) free fraction of thiols rose, while protein-bound fraction dropped (except for homocysteine). Continuous ambulatory
peritoneal dialysis corrects total concentration of glutathione and cysteine, in comparison with nondialyzed patients.
KeywordsChronic kidney disease–Peritoneal dialysis–Terminal renal failure–Thiols
International Urology and Nephrology 04/2012; 43(4):1201-1209. · 1.47 Impact Factor
