[Show abstract][Hide abstract] ABSTRACT: In the present work attempts were made to prepare fast-dispersible tablets of Sertraline by direct compression method with a view to enhance patient compliance. The three superdisintegrants used in this study were Crosscarmellose sodium, Crospovidone and Sodium starch glycolate. Tablets having superdisintegrant at different concentration (8, 10 and 12 mg) level were prepared. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, in-vitro dispersion time and in-vitro dissolution study. Tablet containing crosscarmellose sodium showed excellent in vitro dispersion time and drug release as compared to other formulations. After study, formulation N6 shows short dispersion time with maximum drug release in 40 minutes.