Publications (3)1.08 Total impact
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Article: Cytogenetic alterations in oral squamous cell carcinoma detected by karyotyping (g- banding)
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ABSTRACT: Oral carcinogenesis is a multistep process in which multiple genetic events occurs that alter thenormal functions of genes. Oral squamous cell carcinoma (OSCC) is one of the most common malignanttumours in India. Many patients still die of the disease in spite of therapeutic procedures being improved. Inour study 30 OSCC cases and 10 controls were studied by means of karyotyping using G-band technique, outof which 5 chromosomal abnormal patients were found, in which chromosome 18 deletion being prominent.It is also site specific, 4 out 5 patients with karyotype abnormalities had the tumour on buccal mucosa. It wasalso noted, most of patients with chromosomal abnormality were tobacco chewers, suggesting chemicalcarcinogens in tobacco has an impact on the chromosomes.Oral & Maxillofacial Pathology Journal. 01/2011; -
Article: Potentially malignant disorders of oral cavity
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ABSTRACT: Even though rapid advances have been made in the field of medicine and surgery, cancer is one of the leadingcauses for all human deaths. It is estimated that more than one million new Oral Cancer cases are being detectedannually in the Indian subcontinent, of which 90% are oral squamous cell carcinomas (OSCC). It has been wellestablished by researchers that virtually all OSCC’s are preceded by visible clinical changes in the oral mucosa, usually inthe form of white or red patch. 60-70% of the Indian patients presented for treatment only in the advanced stage ofOral Cancer, leading to high mortality rate. Lack of public awareness about the signs, symptoms and risk factors, alongwith the absence of knowledge for early detection by health-care providers are believed to be responsible for thisdiagnostic delay in identifying the potentially malignant disorders. This article makes an attempt to provide and updatethe knowledge about these disorders to health-care providers in order to help in early detection and treatment of OralCancer, thus reducing its mortality.Oral & Maxillofacial Pathology Journal. 01/2011; -
Article: Expression of inducible nitric oxide synthase (iNOS) in oral precancer and oral squamous cell carcinoma: an immunohistochemical study.
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ABSTRACT: Prolonged production of the free radical, nitric oxide (NO) by the enzyme inducible nitric oxide synthase (iNOS) plays an important role in tumour progression by promoting angiogenesis, invasion and inducing mutation in tumour suppressor gene. The purpose of this study is to evaluate the expression and intensity of iNOS in normal oral mucosa, precancer and oral squamous cell carcinoma (OSCC). An immunohistochemical study was performed using rabbit monoclonal antibody to iNOS on archival formalin fixed, paraffin embedded tissues of 5 normal oral mucosal samples, 10 Leukoplakia, 10 oral submucous fibrosis (OSMF) and 15 OSCC of different grades. A statistical significant difference was found between normal oral mucosa, precancer and OSCC in expression of iNOS (p value 0.0015). However, there was no statistically significant difference between the expressions of iNOS within premalignant groups (p value 0.5647) and histological sub-groups of OSCC (p value-0.5647). There was no statistically significant difference in the intensity of iNOS expression within the precancer group, OSCC sub-groups and between precancer and OSCC (p value-0.623). The orderly increase in the expression of iNOS from normal, through precancer, to OSCC suggests the essential role played by iNOS in epithelial transformation and tumour formation.Cancer biomarkers: section A of Disease markers 8(3):155-60. · 1.08 Impact Factor
