Sebastian Schmidt

Publications (2)4.68 Total impact

• Article: Critical appraisal of clinical practice guidelines for diagnosis and treatment of hepatocellular carcinoma.

  Sebastian Schmidt, Markus Follmann, Nisar Malek, Michael P Manns, Tim F Greten
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  ABSTRACT: Hepatocellular carcinoma (HCC) is the third most common reason for cancer-related death worldwide. Many countries either lack appropriate clinical practice guidelines for the diagnosis and treatment of HCC or the quality of their guidelines has never been evaluated. The main objective of our work was to identify published HCC guidelines and assess their quality with the Appraisal of Guidelines for Research and Evaluation instrument (AGREE) and their suitability regarding adaptation for future guidelines. We performed a systematic literature search on HCC clinical practice guidelines of MEDLINE, National Guidelines Clearinghouse and the Guidelines International Network. Methodological quality of selected guidelines was assessed by the AGREE instrument, Version 2001. A total of 286 citations were screened and 32 relevant guidelines were identified. Overall, the guidelines performed well in the clarity and presentation domain with a mean score of 67%, followed by scope and purpose (55%) and rigor of development (50%). In contrast, poor scores were given for the remaining domains: stakeholder involvement (23%), applicability (28%) and editorial independence (31%). According to the AGREE instrument, four guidelines can be strongly recommended, 18 with provisos and alterations while the remaining cannot be recommended for adaptation due to poor methodological quality. Although existing HCC guidelines may accurately reflect agreed clinical practice, many guidelines lack proper methodological quality. Future guidelines should place more emphasis on these methodological shortcomings.
  Journal of Gastroenterology and Hepatology 08/2011; 26(12):1779-86. · 2.87 Impact Factor
• Source

  Available from: Karsten Wursthorn

  Article: Liver transplantation: A new risk factor for intestinal intussusceptions.

  Sven Pischke, Wursthorn Karsten, Johannes Hadem, Sebastian Schmidt, Karl Heiringhoff Heinz, Fabian Helfritz, Christian P Strassburg, Joachim Lobers, Lars Zender, Oktay Tutarel, Jochen Wedemeyer, Michael P Manns, Heiner Wedemeyer, Kinan Rifai, Michael Gebel
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  ABSTRACT: Intestinal intussusception in adults is associated with chronic inflammatory bowel disease, celiac disease, abdominal tumors or previous abdominal surgery but most often of unknown origin. The aim of our study was to evaluate circumstances and identify risk factors for intussusceptions. All 65,928 abdominal ultrasound examinations performed at our tertiary medical center between January 2001 and June 2008 were analyzed retrospectively for the diagnosis "intussusception". After identifying individuals with sonographically proven intussusception we analyzed various patients' characteristics including age, gender and underlying disease as well as sonographic findings such as localization of the intussusception, absence or presence of ascites and lymph nodes. We identified 32 cases of intussusceptions [mean age 45 years (range 18 to 88); 18 patients were male]. Twelve patients (38%) had a history of abdominal surgery including 8 patients who had undergone liver transplantation (2 patients with primary sclerosing cholangitis, 1 patient with cystic fibrosis, 1 patient with sarcoidosis, 1 patient with hepatocellular carcinoma and HCV infection, 1 patient with autoimmune hepatitis, 1 patient with Crigler-Najar-syndrome and one patient with echinococcus). A hepaticojejunostomy had been performed in 4 of the patients after liver transplantation. Liver transplanted patients were significantly overrepresented in the intussusceptions group compared with the overall cohort of patients undergoing abdominal ultrasound examination (25% vs. 8%, Chi-Square-test, p = 0.0023). In our retrospective study liver transplantation, in particular with hepaticojejunostomy, was identified as a new major risk factor for intestinal intussusceptions
  Annals of hepatology: official journal of the Mexican Association of Hepatology 01/2011; 10(1):38-42. · 1.81 Impact Factor