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ABSTRACT: Among the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli, 3.9% of K. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of ESBL and/or plasmid-mediated AmpC β-lactamase production and porin loss. The presence of bla(CTX-M-14) and loss of OmpK36 were associated with higher carbapenem MICs.
Diagnostic microbiology and infectious disease 03/2011; 71(1):87-9. · 2.45 Impact Factor