Rio P Juni

Publications of Rio P Juni

• Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities.

  Authors: Rinrada Kietadisorn, Rio P Juni, An L Moens

  American journal of physiology. Endocrinology and metabolism. 12/2011; 302(5):E481-95.

  Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of endothelialEndothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of endothelial function. The bioavailability of eNOS-derived NO is crucial for this function and might be affected at multiple levels. Uncoupling of eNOS, with subsequently less NO and more superoxide generation, is one of the major underlying causes of endothelial dysfunction found in atherosclerosis, diabetes, hypertension, cigarette smoking, hyperhomocysteinemia, and ischemia/reperfusion injury. Therefore, modulating eNOS uncoupling by stabilizing eNOS activity, enhancing its substrate, cofactors, and transcription, and reversing uncoupled eNOS are attractive therapeutic approaches to improve endothelial function. This review provides an extensive overview of the important role of eNOS uncoupling in the pathogenesis of endothelial dysfunction and the potential therapeutic interventions to modulate eNOS for tackling endothelial dysfunction.

• Role of sepiapterin on endothelial nitric oxide synthase in acute kidney injury: an enigmatic story.

  Authors: Rio P Juni, An L Moens

  Journal of cardiovascular pharmacology. 09/2011; 58(3):335; author reply 335-336.

• Folic acid enlarges the armamentarium for the treatment of coronary vasospasm.

  Authors: Rio P Juni, Henk J Blom, Harald H Schmidt, An L Moens

  Journal of cellular physiology. 03/2011;

• Modulating iNOS-uncoupling: a new therapeutic avenue to tackle reperfusion-injury?

  Authors: Rio P Juni, An L Moens

  Journal of molecular and cellular cardiology. 02/2011; 50(5):924.