[Show abstract][Hide abstract] ABSTRACT:
Liver Toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. In the present study MEMP leaves is used to screen the hepatoprotective activity. Hepatotoxicity was induced in experimental animals by administration of carbon tetra chloride (CCl4) (25ml/kg, i.p.). Silymarin (25 mg/kg, p.o.) was used as the standard. Functional parameters like onset of sleep and duration of sleep, Biochemical Parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase (SALP), total bilirubin and direct bilirubin were measured. Cytotoxicity of CCl4 was estimated by quantitating the release of malondialdehyde (MDA). The activity of tissue antioxidant enzymes namely super oxide dismutase (SOD), catalase (CAT), and the level of total protein (TP) were also measured. Histopathological evaluation of liver sections was also done. CCl4 administration in rats elevated the levels of SGPT, SGOT, SALP and bilirubin. Administration of MEMP significantly (P<0.001) prevented this increase. The activity of anti-oxidant enzymes in carbon tetrachloride (CCl4) group was decreased and these enzyme levels were significantly (p<0.001) increased in Mallotus philippensis leaves groups. Histopathological studies revealed that the concurrent administration of MEMP with CCl4 exhibited protection of liver tissue, which further evidenced the above results. Thestudy confirmed the hepatoprotective activity of MEMP, which may be attributed to its antioxidant property.