Ricardo L Damatto

Publications (2)3.4 Total impact

• Article: Combined exercise training in asymptomatic elderly with controlled hypertension: effects on functional capacity and cardiac diastolic function.

  Gabriel N Guirado, Ricardo L Damatto, Beatriz B Matsubara, Meliza G Roscani, Danieliso R Fusco, Luiz A F Cicchetto, Marcos M Seki, Altamir S Teixeira, Adriana P Valle, Katashi Okoshi, Marina P Okoshi
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  ABSTRACT: Aging is associated with changes in cardiac structure and function that are associated with left ventricular diastolic dysfunction. Whether diastolic functional alterations during senescence are manifestations of the intrinsic aging process or related to cardiac adaptations to a more sedentary lifestyle is still unsettled. This was a prospective study evaluating the effects of a 6-month combined exercise training period on functional capacity and diastolic function in sedentary elderly patients with controlled arterial hypertension. Functional capacity was assessed by exercise stress test and muscle strength was evaluated by the one-repetition maximum test. Cardiac structures and function were analyzed by transthoracic echocardiography. Fifteen patients, 68±8 years old, completed the training program. Exercise training significantly improved physical capacity (distance walked: 551±92 vs. 630±153 m, P<0.05; work load: 7.2±1.7 vs. 8.5±3.0 METs, P<0.05) and upper and lower extremity muscle strength (P<0.001). Arterial blood pressure significantly decreased after training (systolic blood pressure: 134±9 vs. 128±8 mmHg; diastolic blood pressure: 82±7 vs. 77±6 mmHg; P<0.05). Cardiac structures and left and right systolic and diastolic function did not change after combined training (P>0.05). Combined and supervised training for a 6-month period increases physical capacity and muscle strength in elderly patients with controlled arterial hypertension without changing resting left ventricular diastolic function.
  Medical science monitor: international medical journal of experimental and clinical research 06/2012; 18(7):CR461-5. · 1.70 Impact Factor
• Article: Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors.

  Paula F Martinez, Katashi Okoshi, Leonardo A M Zornoff, Robson F Carvalho, Silvio A Oliveira Junior, Aline R R Lima, Dijon H S Campos, Ricardo L Damatto, Carlos R Padovani, Celia R Nogueira, Maeli Dal Pai-Silva, Marina P Okoshi
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  ABSTRACT: Although intrinsic skeletal muscle abnormalities can influence exercise intolerance during heart failure (HF), the factors responsible for muscle changes have not been elucidated. In this study we evaluated the expression of myogenic regulatory factors (MRF), myosin heavy chain (MyHC) isoforms, and fiber trophism in the soleus muscle of rats with myocardial infarction-induced heart failure. Six months after surgery, 2 groups of rats were studied: sham, and infarcted rats with HF (MI/HF+, MI size: 41.1±6.3% of total left ventricular area). In the infarcted group, microscopic evaluation revealed scattered foci of fiber necrosis in combination with inflammatory cells, phagocytosis, and increased fibrous tissue. The frequency of necrotic fibers was significantly higher in the MI/HF+ group than in the sham. The MI/HF+ group had atrophy of type I, IC/IIC, and IIA fibers compared to the sham group (P<0.05). MyoD gene expression was higher in the MI/HF+ group (sham: 1.00±0.49; MI/HF+: 2.53±0.71 arbitrary units; P<0.001). Myogenin and MRF4 gene expression was similar in both groups. Myogenin protein levels were reduced in the MI/HF+ group (sham: 1.00±0.21; MI/HF+: 0.74±0.21 arbitrary units; P=0.026). MyoD and MRF4 protein levels, as well as the MyHC distribution, were not different between groups. The MI/HF+ group had higher TNF-α and IL-6 serum concentrations than the sham group. Heart failure-induced skeletal muscle atrophy is combined with fiber necrosis, increased MyoD gene expression and decreased myogenin protein levels.
  Medical science monitor: international medical journal of experimental and clinical research 11/2010; 16(12):BR374-83. · 1.70 Impact Factor