P J Prichard

Publications (2)3.61 Total impact

• Article: Type 2 diabetes does not worsen prognosis in hepatocellular carcinoma.

  J Howell, M Yiu, R Gibson, B Thomson, D Stella, A Gorelik, P J Prichard, A J Nicoll
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  ABSTRACT: Type 2 diabetes (T2DM) is associated with liver inflammation and carcinogenesis. The prevalence of T2DM among patients with liver cirrhosis and hepatocellular carcinoma is increasing. However, the effect of T2DM on the natural history of hepatocellular carcinoma is not known. To examine the effect of T2DM on hepatocellular carcinoma (HCC) survival in treated and untreated disease. Retrospective analysis was performed on HCC cases diagnosed during 2000-2005, and prospectively during 2006-August 2007. Demographics, HCC staging, response to treatment, and survival were collected. A comparison was made between patients with T2DM and without T2DM. One hundred and thirty-five patients were recruited in total; 58 (43%) had T2DM. Seventy (37 diabetic) patients were treated with percutaneous radiological therapies, with 168 treatments given. Treatment was determined by AASLD guidelines and patient tolerance, there was no randomisation. There was no significant difference in survival between diabetic and nondiabetic patients. There was a nonsignificant trend towards greater survival in diabetic patients (overall median survival diabetics 21 mths vs nondiabetics 5 mths, P=0.355). T2DM does not negatively impact on the natural history of treated or untreated HCC.
  Gastroentérologie Clinique et Biologique 03/2011; 35(3):214-20. · 0.80 Impact Factor
• Article: Colorectal cancer.

  P J Prichard, J J Tjandra
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  ABSTRACT: Colorectal cancer is the leading cause, after lung cancer, of death from cancer in Australia. About 50% of colorectal cancers are attributed to dietary factors and about 15%-20% to genetic factors, including high risk familial syndromes. The most common presenting symptoms are rectal bleeding (left-sided cancers) and iron-deficiency anaemia (right-sided cancers). Patients with suggestive symptoms should have a digital rectal examination, followed by sigmoidoscopy and biopsy if a rectal lesion is suspected, or colonoscopy if colon cancer is suspected. Treatment of most colorectal cancers is segmental resection with a wide resection margin; the role of adjuvant therapy is still being refined. Screening with annual (or biennial) faecal occult blood tests is recommended for people over 50 years without symptoms and with average or slightly above average risk; more intensive, earlier screening is recommended for those with greater risk.
  The Medical journal of Australia 12/1998; 169(9):493-8. · 2.81 Impact Factor