Noel S Weiss

Publications (2)6.17 Total impact

• Article: Hospital surveillance of childhood bacterial meningitis in Senegal and the introduction of Haemophilus influenzae type b conjugate vaccine.

  Osseynou Ba, Jessica A Fleming, Yakou Dieye, Boniface Mutombo wa Mutombo, Mamadou Ba, Moussa Fafa Cisse, Aissatou Gaye Diallo, Iyane Sow, Mary P E Slack, Pape Coumba Faye, Mady Ba, Ndiouga Diallo, Noel S Weiss
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  ABSTRACT: Bacterial meningitis is an important cause of morbidity and mortality in children living in low-resource settings. Pediatric bacterial meningitis cases < 5 years of age were identified through a regional hospital surveillance system for 3 years after introduction of routine immunization with Haemophilus influenzae type b (Hib) conjugate vaccine in Senegal in July 2005. Cases from the national pediatric hospital were also tracked from 2002 to 2008. The regional surveillance system recorded 1,711 suspected pediatric bacterial meningitis cases. Of 214 laboratory-confirmed cases, 108 (50%) were caused by Streptococcus pneumoniae, 42 (20%) to Hib, and 13 (6%) to Neisseria meningitidis. There was a 98% reduction in the number of hospitalized Hib meningitis cases from Dakar Region in 2008 compared with 2002. The surveillance system provides important information to the Ministry of Health as they consider self-funding Hib vaccine and introducing pneumococcal vaccine.
  The American journal of tropical medicine and hygiene 12/2010; 83(6):1330-5. · 2.59 Impact Factor
• Article: Effectiveness of haemophilus influenzae type B conjugate vaccine for prevention of meningitis in Senegal.

  Jessica A Fleming, Yakou Dieye, Ousseynou Ba, Boniface Mutombo wa Mutombo, Ndiouga Diallo, Pape Coumba Faye, Mamadou Ba, Moussa Fafa Cisse, Aissatou Gaye Diallo, Mady Ba, Mary P E Slack, Noel S Weiss
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  ABSTRACT: A total of 24 cases of hospitalized, laboratory-confirmed Haemophilus influenzae type b (Hib) meningitis were identified through a regional pediatric bacterial meningitis surveillance system. Each case was matched by age and residence to 4 neighborhood controls. The adjusted vaccine effectiveness for ≥ 2 doses was 95.8% (95% confidence interval, 67.9%-99.4%). Hib vaccine appears to be highly effective in preventing Hib meningitis in Senegal.
  The Pediatric Infectious Disease Journal 11/2010; 30(5):430-2. · 3.58 Impact Factor