Publications (2)0 Total impact
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Article: Investigation effect of pioglitazone, glimepiride, nobivolol, valsartan and hesperidine on glucose, HbA1c and blood pressure in experimentally induced myocardial infarction in type 2 diabetic rats
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ABSTRACT: Present study was designed to evaluate effect some synthetic drugs and some herbal compound on Glucose, HbA1c and Systolic and diastolic blood pressure in isoproterenol induced myocardial infarction in normal and Streptozotocin-Nicotinamide induced diabetic in rats. Pioglitazone (10 mg/kg, p.o), Glimepiride (0.5 mg/kg, p.o), Nobivolol (2 mg/kg, p.o), Valsartan (8 mg/kg, p.o) and Hesperidin (100 mg/kg, p.o) were administered for 28 days in rats injected with single dose of Streptozotocin (65 mg/kg, i.p, STZ) and Nicotinamide (12mg/kg, i.p, NIC) and after isoproterenol (200 mg/kg, s.c.) induced myocardial infarction in rats on 29th and 30th day. At the end of experimental period (i.e. on the day 31) serum sample were collected, and glucose, HbA1c were find out and measurement of systolic and diastolic blood pressure. Administration of STZ–NIC in rats showed a significant (p<0.001) increased in the levels of serum glucose and glycosylated hemoglobin (HbA1c) and significant (p<0.01) increased in the level systolic and diastolic blood pressure as compared to respective control groups. Treatment with Pioglitazone, Glimepiride and Hesperidin significantly (P<0.05) decreased HbA1c, glucose, systolic and diastolic blood pressure but treatment with Nobivolol and Valsartan significantly (p<0.01) decreased without change on glucose and HbA1c. This study concluded that Pioglitazone, Glimepiride and Hesperidin may show reduced diabetes marker and systolic and diastolic blood pressure but Nobivolol and Valsartan may show reduced only systolic and diastolic blood pressure on experimentally induced myocardial infarction in type 2 diabetic rats.International Journal of Research in Pharmaceutical Sciences. 01/2010; -
Article: Effect of Nebivolol on Renal Complication in Diabetes–An Experimentally Study in Rats
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ABSTRACT: Present study was designed to evaluate the effect of Nebivolol on renal complication in diabetic rats. Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation in diabetic condition, is a major cause of acute renal failure. Type 2 Diabetes was induced in rats by a single intraperitoneal (i.p) injection of Streptozotocin (65 mg/kg, STZ) in overnight fasting rats followed by the i.p administration of Nicotinamide (110 mg/kg, NIC) after 15 minutes. After right nephrectomy, Nebivolol (2 mg/kg/day, p.o) was administered for 15 days. On the 16th day, ischemia was induced in contra lateral kidney for 45 min, followed by reperfusion for 24 hr. Renal function marker and histopathology were estimated at the end of 24 hr reperfusion. At the end of experimental period the level of nitrite in kidney tissue, serum marker Albumin and Blood urea nitrogen were significantly changed. Nebivolol improved the renal dysfunction and nitrite after renal ischemia/reperfusion injury in diabetic rats. Light microscopic evaluation of the kidneys of the diabetic rats with I/R only showed tubular cell swelling, interstitial edema, tubular dilatation, and moderate to severe necrosis, whereas, Nebivolol Reduced tubular dilation, loss of interstitial hemorrhage, and glomerular atrophy. In conclusion, Nebivolol as a beneficial agent in the treatment of Ischemia/reperfusion induced renal damage in diabetic rats.
