Publications (2)0 Total impact
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ABSTRACT: Postoperative pain control has been studied extensively, including many perioperative pain control procedures. Unfortunately, the impact of the surgical technique was not objectively studied. The aim of this study is to evaluate if the type of surgical dissection needed for extensive abdominal wall dissection actually has an effect in the reduction of postoperative pain or not. Forty adult patients, 19 males and 21 females, were randomly divided into two groups with each group containing 20 patients having different varieties of anterior abdominal wall ventral hernia. Patients in group I had their hernias and abdominal wall flaps dissected by only sharp dissection using scalpel. Patients in group II had their hernias and abdominal wall flaps dissected using mainly blunt dissection assisted by sharp dissection where blunt dissection could not do the job. All the patients had general anesthesia. No preemptive analgesia was used. Nalbufen was used as the only postoperative pain killer and the total amount used of it was treated as the indicator for the intensity of postoperative pain. The results of the present study showed that the total amount of Nalbufen used for the control of postoperative pain is significantly less in group I throughout the postoperative follow-up period. This study concludes that use of sharp dissection in cases of extensive abdominal wall dissection is statistically better than other methods of dissection in terms of postoperative pain control.Saudi journal of anaesthesia. 09/2010; 4(3):127-30.
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ABSTRACT: Mammary serine protease inhibitor (Maspin) is down regulated in breast and prostate cancers and is considered as a tumor suppressor gene. On the contrary, it is over expressed in pancreatic and ovarian carcinomas and is reported to be an oncogene rather than a tumor suppressor gene. The studies of maspin expression in thyroid neoplasia, the focus of this study, are limited. We, therefore, carried out this work in order to detect the frequency and pattern of maspin expression in thyroid neoplasia. An immunohistochemical approach was performed on 63 thyroid specimens showing different benign and malignant thyroid lesions. Also, five specimens of the surrounding normal thyroid tissue were included as control. A monoclonal anti-human antibody has been used to detect maspin. Maspin was only detected in papillary thyroid carcinoma (PTC) and it was negative in all other studied thyroid tissues. In PTC 18/25 (72%) cases were maspin positive. Most of them 11/18 (61.1%) showed both cytoplasmic and nuclear maspin expression, two cases 2/18 (11.1%) were nuclear and the rest of the specimens, 5/18, (27.8%) were cytoplasmic only. There was no statistically significant relation between maspin positive cases and the studied clinicopathological parameters including patient's age, sex and tumor stage. On the other hand, it was statistically significant as regards tumor multicentricity, vascular and lymphatic invasion, as well as lymph node metastasis. Maspin expression is a special feature of papillary thyroid carcinoma (PTC) which can be used as a therapeutic target. It may be suggested that the genesis of PTC may be different from other types of thyroid carcinoma. Further studies regarding its prognostic role in patients with PTC are recommended.Journal of the Egyptian National Cancer Institute 09/2006; 18(3):274-80.