Mingjie Chen

Zhejiang University, Hang-hsien, Zhejiang Sheng, China

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Publications (7)15.93 Total impact

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    ABSTRACT: A two-feed simulated moving bed (SMB) was proposed to utilize the stationary phase more effectively. Zone I is disconnected with zone II and zone III is disconnected with zone IV. Two feeds are added to zones I and III, while two desorbents are added to zones II and IV separately. The investigation on the movement of concentration bands indicated that the tail of the strong retained solute and the front of the weak retained solute were eluted from zones I and III orderly, so the streams from zones I and III could be cut into different fractions to give the products with high purity. The two-feed SMB was used to separate α-tocopherol from its homologue mixture successfully, and could double the productivity if both feeds were identical to the feed in the conventional four-zone SMB. The solvent consumption could be reduced by reusing the middle fraction without solutes.
    Chinese Journal of Chemical Engineering 08/2012; 20(4):673–678. DOI:10.1016/S1004-9541(11)60234-6 · 0.87 Impact Factor
  • Feng Wei, Bo Shen, Mingjie Chen, Yingxian Zhao
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    ABSTRACT: Two simulated moving-bed (SMB) cascades are proposed for the separation of a ternary mixture containing the least, medium-, and most retained solutes (A, B, and C). Each cascade has a total of five zones. The first cascade combines two three-zone SMBs sharing zone III: the one SMB with zones I to III separates (A+B+C) into A and (B+C), and the other three-zone SMB with zones III to V separates (B+C) into B and C. The second cascade combines a four-zone SMB consisting of zones I to IV and a three-zone SMB comprising zones IV, V and I: the former separates (A+B+C) into (A+B) and C, and the latter separates (A+B) into A and B. Analysis of the concentration band movement together with a modeling study confirms the feasibilities of the two cascades, suggesting that the first cascade should be adopted if the separation of (A+B) and C is easier than that of A and (B+C), and otherwise, the second cascade should be used.
    Industrial & Engineering Chemistry Research 04/2012; 51(16):5805–5812. DOI:10.1021/ie2024189 · 2.24 Impact Factor
  • Feng Wei, Bo Shen, Mingjie Chen, Yingxian Zhao
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    ABSTRACT: There is a trapping effect on the solute in the simulated moving bed (SMB) with solvent gradient. As the eluotropic strength of the liquid in zone II (between the extract-port and feed-port) is higher than that in zone III (between the feed-port and the raffinate-port), the solute can move forward in zone II but backward in zone III to be trapped in the two zones consequently. On this basis, a pseudo-SMB was proposed to separate the medium retained solute from a ternary mixture by selectively trapping the medium retained solute. Once the columns in zones II and III are saturated with the target solute, the solvent dissolving the feed is introduced at the feed-port to remove the least retained solute from the raffinate-port and the most retained solute from the extract-port. Finally, the target solute is recovered. A model simulation was used to investigate the behavior and performance of a system operating with this technology. The results showed that increasing the columns in zone III could trap more target solutes since the eluotropic strength decreased from zone II to zone III. Partial recovery in combination with incomplete purification could improve the separation performance in terms of the productivity and solvent consumption without losing purity.
    Journal of Chromatography A 02/2012; 1225:99-106. DOI:10.1016/j.chroma.2011.12.080 · 4.26 Impact Factor
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    ABSTRACT: A three-zone SMB was proposed to reduce the adsorbent usage, where zone I normally used to regenerate the adsorbent is discarded and the desorbent is directly pumped into zone II. An analysis on the movement of the concentration band indicates that the tail of the more retained solute is desorbed successively in zones II and IV, without overlapping with the front of the less retained solute in zone IV. As a result, the raffinate and extract product can be collected from the outlets of zones III and IV, respectively. The model simulations confirm that the three-zone SMB dropping zone I can lower the adsorbent usage and system pressure without losing the purity. In comparison with the four-zone SMB and another three-zone SMB dropping zone IV, the solvent consumption is lower than that by the latter, but higher than that by the former. The partial withdrawal operation can reduce the solvent consumption in the two SMBs without zone I and without zone IV. For anti-Langmuir isotherm dropping zone I is more effective than dropping zone IV.
    Separation Science and Technology 03/2011; 46(5):695-701. DOI:10.1080/01496395.2010.537730 · 1.20 Impact Factor
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    ABSTRACT: A novel pseudo simulated moving bed was suggested to separate a ternary mixture. A solvent gradient was created to make the solvent strength decreasing from zone II to zone III. Under suitable conditions, the least retained solute A moved forward and the most retained solute C moved backward in zones II and III whereas the medium retained solute B moved forward in zone II but backward in zone III to be trapped in the two zones consequently. Once the columns in zones II and III were saturated with solute B, the solvent dissolving the feed was introduced at the feed port to remove solute A from the raffinate-port and solute C from the extract-port. Finally, solute B was recovered from the extract port by stopping the liquid flow in zone II. This scheme was validated by the successful separation of dihydrocapsaicin from capsaicinoids.
    Journal of Chromatography A 03/2011; 1218(20):2906-11. DOI:10.1016/j.chroma.2011.03.001 · 4.26 Impact Factor
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    ABSTRACT: A new feeding mode for a simulated moving bed (SMB) is proposed. The outlet stream from zone II is collected at regular intervals. The concentration of the solution is increased by dissolving raw materials and then fed to zone III as the feed stream during the next collection interval. In this feeding mode, the concentration of the stream fed to zone III is identical to that of original feed, while in a conventional SMB, the feed is diluted by mixing with the outlet stream of zone II before feeding to zone III. The new feeding mode increases the inlet concentration of zone III. A modeling investigation shows that higher inlet concentration of zone III increases the height of concentration band in SMB, improving the separation performance significantly. In comparison with the traditonal feeding mode, the new feeding mode increases the productivity by 23.52% and decreases the solvent consumption by 22.56%, so as to increase the raffinate and extract concentrations by 53.17% and 20.38%, respectively. The collection interval for the outlet stream from zone II has no effect on the separation performance after reaching the steady state, so that the collection interval can be increased to make the operation more convenient.
    Chinese Journal of Chemical Engineering 04/2010; 18(2):239-243. DOI:10.1016/S1004-9541(08)60348-1 · 0.87 Impact Factor
  • Feng Wei, Bo Shen, Mingjie Chen
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    ABSTRACT: Enantioseparation of omeprazole was conducted with a chiral simulated moving bed chromatography (SMBC) process. The coated triphenylcarbamate cellulose chiral stationary phase (CSP) was preparared and used as the CSPs in the SMBC, while ethanol was selected as the eluent after several solvents were screened using analytical chromatography. S-Omeprazole with a purity of 96.4% was obtained from the SMBC. A simulated moving bed (SMB) model was used to simulate the SMBC process. The size required for SMBC is small; therefore, the dead volume caused by connection tubes is somewhat large, relative to the column volume. If the dead volume was supposed to be zero, the simulation would be very bad. Two approaches were used to take into account any effects that were due to the dead volume. The simulations match the experimental data well and can effectively validate the given operation conditions.
    Industrial & Engineering Chemistry Research 01/2006; 45(4). DOI:10.1021/ie050529a · 2.24 Impact Factor