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Yu Zhang,
Jian-Feng Wang,
Jing Dong,
Jing-Yuan Wei,
Ya-Nan Wang,
Xiao-Han Dai,
Xin Wang, Ming-Jing Luo,
Wei Tan,
Xu-Ming Deng,
Xiao-di Niu
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ABSTRACT: Staphylococcal pneumonia provoked by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening infection in which α-toxin is an essential virulence factor. In this study, we investigate the influence of naringenin on α-toxin production and further assess its therapeutic performance in the treatment of staphylococcal pneumonia. Remarkably, the expression of α-toxin was significantly inhibited when the organism was treated with 16μg/ml of naringenin. When studied in a mouse model of S. aureus pneumonia, naringenin could attenuate the symptoms of lung injury and inflammation in infected mice. These results suggest that naringenin is a promising agent for treatment of S. aureus infection.
Fitoterapia 02/2013; · 1.85 Impact Factor
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Hong-en Li,
Jia-zhang Qiu,
Zhan-qing Yang,
Jing Dong,
Jian-feng Wang, Ming-jing Luo,
Juan Pan,
Xiao-han Dai,
Yu Zhang,
Bai-lin Song,
Xu-ming Deng
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ABSTRACT: In the present study, the antimicrobial activity of glycyrrhetinic acid (GA) against Staphylococcus aureus, and its influence on the production of S. aureus alpha-haemolysin (Hla) were investigated, along with the in vivo activity of GA against S. aureus-induced pneumonia. GA could not inhibit the growth of S. aureus, but the secretion of Hla by S. aureus was significantly inhibited by low concentrations of GA in a dose-dependent manner. Furthermore, in vivo data show that GA provides protection against staphylococcal pneumonia in a murine model system.
Fitoterapia 11/2011; 83(1):241-8. · 1.85 Impact Factor
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Bing-Feng Leng,
Jia-Zhang Qiu,
Xiao-Han Dai,
Jing Dong,
Jian-Feng Wang, Ming-Jing Luo,
Hong-En Li,
Xiao-Di Niu,
Yu Zhang,
Yong-Xing Ai,
Xu-Ming Deng
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ABSTRACT: Staphylococcus aureus causes a broad range of life-threatening diseases in humans. The pathogenicity of this micro-organism is largely dependent upon its virulence factors. One of the most extensively studied virulence factors is the extracellular protein α-toxin. In this study, we show that allicin, an organosulfur compound, was active against S. aureus with MICs ranged from 32 to 64 μg/mL. Haemolysis, Western blot and real-time RT-PCR assays were used to evaluate the effects of allicin on S. aureus α-toxin production and on the levels of gene expression, respectively. The results of our study indicated that sub-inhibitory concentrations of allicin decreased the production of α-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) in a dose-dependent manner. Furthermore, the transcriptional levels of agr (accessory gene regulator) in S. aureus were inhibited by allicin. Therefore, allicin may be useful in the treatment of α-toxin-producing S. aureus infections.
Molecules 01/2011; 16(9):7958-68. · 2.39 Impact Factor
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ABSTRACT: The present study aimed to evaluate the antimicrobial activity of peppermint oil against Staphylococcus aureus, and further investigate the influence of peppermint oil on S. aureus virulence-related exoprotein production. The data show that peppermint oil, which contained high contents of menthone, isomenthone, neomenthol, menthol, and menthyl acetate, was active against S. aureus with minimal inhibitory concentrations (MICs) ranging from 64-256 µg/mL, and the production of S. aureus exotoxins was decreased by subinhibitory concentrations of peppermint oil in a dose-dependent manner. The findings suggest that peppermint oil may potentially be used to aid in the treatment of S. aureus infections.
Molecules 01/2011; 16(2):1642-54. · 2.39 Impact Factor
