Mehmet Yilmazer

Afyon Kocatepe University, Kara Hissar Sahib, Afyonkarahisar, Turkey

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Publications (48)76.52 Total impact

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    ABSTRACT: The present study aims to specify the role of L-carnitine in the pathogenesis of endometrial cancer by comparing the serum total L-carnitine levels of endometrial cancer patients with those of healthy women.
    Archives of Gynecology and Obstetrics 10/2014; · 1.33 Impact Factor
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    ABSTRACT: Premenstrual syndrome (PMS) is a disorder related to mood and appetite changes during the premenstrual phase. Unfortunately, the understanding of the pathophysiology of PMS is quite poor. Though, ghrelin and leptin play important roles in the control of food intake. The aim of this study was to evaluate leptin and ghrelin serum concentrations in PMS patients.
    European review for medical and pharmacological sciences. 10/2014; 18(20):3010-5.
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    ABSTRACT: AimThe present study aims to determine whether mean platelet volume (MPV) specified in late first trimester of pregnancy can be used to predict pre-eclampsia and intrauterine growth restriction (IUGR).Methods This study prospectively reviews 200 healthy women with 11–14-week-old pregnancies.ResultsAverage pregnancy-associated plasma protein-A (PAPP-A) multiples of the median (MoM) value was significantly lower and MPV was significantly higher in pre-eclamptic pregnancies (P = 0.001 for both). MPV values of 10.5 fl or more can predict pre-eclampsia with 66.7% sensitivity and 63.8% specificity. The combination of MPV of 10.5 fl or more and PAPP-A MoM of 0.33 or less can predict pre-eclampsia with 75% sensitivity and 70.0% specificity. MPV values of 10.5 fl or more can predict IUGR with 82.4% sensitivity and 60.0% specificity. The combination of MPV of 10.5 fl or more and PAPP-A MoM of 0.33 or less can predict IUGR with 85.3% sensitivity and 62.0% specificity.Conclusion Increased MPV reflects enhanced platelet activation which may be caused by impairment in uteroplacental circulation. When MPV of 10.1 or more and PAPP-A MoM of 0.33 or less are combined as a threshold, the pregnancies that are destined to develop IUGR and pre-eclampsia can be predicted with considerably high sensitivity and specificity. The MPV and PAPP-A combination can be addressed as a useful biochemical tool for the prediction of IUGR and pre-eclampsia in late first trimester.
    Journal of Obstetrics and Gynaecology Research 07/2014; 40(7). · 0.84 Impact Factor
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    ABSTRACT: We examine the perinatal outcomes of borderline diabetic pregnant women who have impaired 50 g oral glucose challenge test (OGCT) results, but normal 100 g oral glucose tolerance test (OGTT) results. Our study group included 70 pregnant women who had increased 50 g OGCT results, but normal 100 g OGTT results, and a control group of 122 pregnant women with normal 50 g OGCT results. Polyhydramnios, macrosomia and neonatal birth weight were significantly higher in the study group. After adjusting the results for possibly affecting variables, the risk of polyhydramnios remained significant, while the risk of macrosomia and neonatal birth weight was not significant between the groups. The results from the study group were similar to the control group, when adjusted for other risk factors. Increased 50 g OGCT results in pregnant women can be accepted as a benign state if the 100 g OGTT results are normal.
    Journal of Obstetrics and Gynaecology 06/2014; · 0.55 Impact Factor
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    ABSTRACT: The role and applicability of three-dimensional ultrasound (3D-US) in perinatology has been repeatedly discussed in the literature. Regardless, our knowledge about patient expectations remains limited. We aimed at determining the expectations, perception and knowledge of pregnant women about 3D-US. Upon admission to the labor unit, the women filled out a questionnaire, with the help of a doctor investigating sociodemographic data, pregnancy and delivery history previous experiences and expectations for US imaging. A total of 644 pregnant women were included in the study Respondents declared that approximately 70% of all kinds of structural abnormalities could be detected by 3D-US and estimated its reliability at nearly 70%. While 60% of the participants underwent 3D-US, 70% of them believed that every pregnant woman should undergo such test. Also, 457 (70.9%) of the participants were of the opinion that every pregnant woman must undergo 3D-US imaging, whereas 173 (26.8%) did not think 3D-US imaging was necessary To the best of our knowledge, this has been the first study on patient opinions regarding the need for 3D-US imaging during pregnancy Although the participants were not certain about the harmful effects of 3D-US, the majority believed that it was necessary for every pregnant woman to undergo such testing. Obviously patients must be instructed on the limitations of US imaging before the examination to clarify any misunderstandings about the possibilities such a technique may offer
    Ginekologia polska 01/2014; 85(1):31-6. · 0.79 Impact Factor
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    ABSTRACT: Abstract Objective: The present study aims to determine the efficiency and reliability of TENS in the management of pain related with uterine contractions after vaginal delivery and the pain related with both abdominal incision uterine contractions after cesarean section. Methods: A hundred healthy women who underwent cesarean section under general anesthesia were randomly assigned to the placebo group (Group 1) or the TENS group (Group 2) while 100 women who delivered by vaginal route without episiotomy were randomized into the placebo group (Group 3) or the TENS group (Group 4) Results: The patients in Group 2 had statistically lower VAS and VNS scores than the patients in Group 1 (p<0.001 for both). The patients in Group 4 had statistically lower VAS and VNS scores than the patients in Group 3 (p=0.022 and p=0.005 respectively). The analgesic requirement at the eighth hour of cesarean section was significantly lower in the patients who were treated with TENS (p=0.006). The need for analgesics at the eighth hour of vaginal delivery was statistically similar in the patients who were treated with TENS and the patients who received placebo (p=0.830). Conclusion: TENS is an effective, reliable, practical, and easily available modality of treatment for postpartum pain.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 11/2013; · 1.36 Impact Factor
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    ABSTRACT: Abstract Objective: This study investigates whether maternal sociodemographic and clinical characteristics influence the site of placental implantation so that placental localization and associated abnormalities can be predicted. Methods: This study reviews 500 healthy women with singleton pregnancy that were consecutively admitted to the study center and eventually delivered healthy newborns. Results: The most frequently observed sites of placentation were anterior uterine wall (53.2%), posterior uterine wall (28.8%), lateral uterine walls (10.0%) and uterine fundus (8.0%) respectively. The women with fundal placentation had significantly higher systolic and diastolic blood pressures (respectively p=0.044 and p=0.040). Supine sleeping position was more frequent in women with anterior placenta and (OR: 11.568, 95% CI: 2.720-49.193) and prone sleeping position was more frequent in women with posterior placenta (OR: 15.449, 95% CI: 2.151-52.978) (p=0.001). The women who favored to sleep in right lateral position were more likely to have lateral placentation while the women who used to sleep in left lateral position were more likely to have fundal placentation (p=0.001). Conclusions: Sleeping position in early pregnancy may influence placental implantation site. The probable mechanism may refer to the alterations in uterine perfusion which is induced by the change in systemic blood pressure and dominant sleeping position.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 11/2013; · 1.36 Impact Factor
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    ABSTRACT: ABSTRACT Objective: This study aims to compare the serum total L-carnitine concentrations of obese and non-obese pregnant women and to identify the role of L-carnitine in both maternal and fetal weight gain during pregnancy. Methods: This study reviews 118 healthy women with singleton term pregnancy (≥37 weeks). The characteristics of the recruited subjects were analyzed according to their pre-pregnancy body mass index (BMI). Results: The women with pre-pregnancy BMI<18.5 kg/m(2) had significantly higher serum L-carnitine levels whereas the women with BMI>29.9 kg/m(2) at term pregnancy had significantly lower serum L-carnitine levels (p=0.001 for both). The neonates born to women with BMI > 29.9 kg/m(2) at term pregnancy had significantly longer height and wider head circumference (p=0.001 for both). Serum total L-carnitine levels correlated significantly and negatively with pre-pregnancy body weight, pre-pregnancy BMI, pregnancy body weight, pregnancy BMI and serum triglyceride levels (r=-0.397, p=0.001; r=-0.357, p=0.001; r=-0.460, p=0.001; r=-0.463, p=0.001 and r=-0.216, p=0.019 respectively). There was a significant and positive correlation between L-carnitine and HDL values (r=0.243, p=0.008). Conclusions: The crucial role of L-carnitine in pregnancy metabolism suggests that nutritional supplementation of this amino acid can be offered to women who are either overweight or obese at the beginning of the pregnancy.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 04/2013; · 1.36 Impact Factor
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  • North American journal of medical sciences. 12/2012; 4(12):659-61.
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    ABSTRACT: We aimed to explore the effects of ischaemic preconditioning (IP) used to reduce ischaemic injury during laparoscopy on ovarian apoptosis and p53 expression. A total of 32 rats were randomly allocated into four groups consisting of eight in each as follows: Group I was subjected to a sham operation without pneumoperitoneum (Pp). Group II was subjected to 5 min of Pp with 15 mmHg pressure of CO(2) followed immediately by 5 min of deflation, after that, 60 min of Pp and deflation. Group III was subjected to 10 min of Pp and deflation. Group IV was subjected to 60 min of Pp and deflation. The ovarian tissues were histologically and immunohistochemically processed. The number of apoptotic and p53(+) cells were measured. All the data revealed that ovarian apoptosis and p53 expression were highest in group IV. Apoptotic cells and p53(+) cells were lower in IP groups. Additionally, group II had significantly lower p53(+) cells compared with group III. Pp induces higher amount of apoptosis and p53 expression in ovary but preconditioning may have protective effects during laparoscopy. Furthermore, 5 min of preconditioning may be more effective. Therefore, the effects of Pp and preconditioning should be considered for the ovary during laparoscopy.
    Journal of Obstetrics and Gynaecology 07/2012; 32(5):467-71. · 0.55 Impact Factor
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    ABSTRACT: Vaginal cavernous hemangioma is a considerably rare condition during pregnancy. There has only been one reported case to date. A multiparous, 24-year-old woman in the 32nd week of pregnancy was admitted with a mass prolapsed from the vagina, which had suddenly increased in size over the previous few days. A necrotic mass obstructing the vaginal canal and originating from the posterior wall was observed in a pelvic physical examination and carefully excised. The patient had contractions after the intervention and was administered tocolytic treatment with bed-rest and fluids. Her obstetric clinical status was stable after treatment and she gave birth without complication at 37 weeks and 5 days from the vaginal canal. The main approach to these very rare tumors of pregnancy, especially in the presence of necrosis, infection and/or obstruction, should be excision. But the potential for increased blood loss that may occur due to the hypervascular structure of the tumor should be taken into account.
    Journal of Obstetrics and Gynaecology Research 03/2012; 38(5):889-91. · 0.84 Impact Factor
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    ABSTRACT: To evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) for decreasing pain related with office endometrial biopsy. In this prospective study, 65 women undergoing office endometrial biopsy were randomly allocated to receive 550 mg oral naproxen sodium plus active TENS (Group I, n = 33) or 550 mg oral naproxen sodium plus placebo TENS (Group II, n = 32). The intensity of pain perceived by the patients was measured using a 10-cm visual analog scale (VAS) before insertion of the speculum, when the cervix grasped, immediately after biopsy, and 15 min after the procedure. The effect of anxiety (Spielberger's state anxiety inventory) on pain scores was also investigated. There were no statistical significant differences between groups in age, weight, body mass index, gravidity, parity, education, and menopausal status (p > 0.05). The pain scores before insertion of the speculum, when the cervix grasped, and immediately after biopsy were similar in both groups (p > 0.05). But at 15 min after the procedure, there was a significant reduction of the mean VAS pain score in naproxen sodium plus TENS group, compared with the naproxen sodium plus placebo TENS group (0.14 ± 0.47, 1.44 ± 1.37, respectively, p < 0.0001). The mean anxiety scores were 48.19 ± 6.71 and 45.85 ± 6.22 in Group I and Group II, respectively. We did not find any significant correlation between anxiety and VAS pain scores (p > 0.05). TENS appears to be successful in decreasing pain only after the procedure undergoing office endometrial biopsy. It can be used as a simple, cheap, safe, and effective pain relief method.
    Archives of Gynecology 10/2011; 285(4):1059-64. · 0.91 Impact Factor
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    ABSTRACT: In this study, we looked for a relationship between the extent of angiogenesis and mast cell density (MCD) in human leiomyomas and endometrial carcinomas (EC), and investigated the clinicopathological relevance of mast cells (MCs) in EC. Specimens of 15 control, 20 leiomyoma, and 23 EC patients were investigated immunohistochemically using anti-CD31 and anti-tryptase antibodies. In EC, both stromal and myometrial expressions of CD31 were significantly higher than in the controls (p<0.01 and p=0.013; respectively). Stromal tryptase expression was not significantly lower than that of leiomyoma. In addition, in the leiomyoma group, CD31 and tryptase expressions were not much different compared to the controls. Moreover, a correlation was detected between cancer histological grade and both stromal and myometrial expressions of CD31 (p=0.017 and p=0.005; respectively). The findings show that high grade EC has a higher degree of vascularization than EC of lower grade, but MCD does not increase in parallel with the histological grade. This study has demonstrated that MCD does not correlate with angiogenesis and progression of grade in EC. Moreover, MCD in EC was found to be lower than in benign lesions of the uterus. In conclusion, MCs may not account for the angiogenic process which facilitates tumor growth.
    Pathology - Research and Practice 08/2011; 207(10):618-22. · 1.21 Impact Factor
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    ABSTRACT: Objective In this study, we aimed to investigate the temperament and character dimensions of women with nausea and vomiting in early pregnancy.MethodsA hundred consecutive women with or without nausea and vomiting of pregnancy (NVP) enrolled in the study. They were examined by using the temperament and character inventory and prospectively scored NVP of them using the Rhodes’ system. These scores and demographic data were compared and P < 0.05 was considered significant.ResultsWomen with NVP were scored lower in HA4 (less fatigability and asthenia; P = 0.029), C2 (less emphatic; P = 0.001) compared to women without NVP. Among 74 pregnant women with NVP 29 of them had mild, 41 had moderate and four of them had severe NVP according to the Rhodes’ score. NS2 (impulsiveness), NS3 (extravagance) and total NS scores showed negative correlation with Rhodes scores (r = −0.246, P = 0.014; r = −0.216, P = 0.031 and r = −0.219, P = 0.029, respectively). C3 (helpfulness) scores were positively correlated with Rhodes’ scores (r = 0.234, P = 0.019).Conclusion These results suggest that NVP in early pregnancy has distinctive temperament and character dimensions compared to non-NVP women in early pregnancy.
    Neurology Psychiatry and Brain Research 03/2011; 17(1):11–15. · 0.13 Impact Factor
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    ABSTRACT: To compare the efficacy of cabergoline (Cb2) and meloxicam in curbing vascular endothelial growth factor (VEGF) expression and preventing ovarian hyperstimulation syndrome (OHSS). Randomized controlled, animal study. Academic facility. We used a total of 50 immature Wistar female rats randomly to create an experimental OHSS model. Ten rats each formed the control group and mild OHSS group. The remaining 30 were separated into three equal groups of severe OHSS. Mild and severe OHSS were induced through ovarian stimulation with gonadotropins. One group with severe OHSS was administered a low-dose 100 microg/kg Cb2 therapy; another group with severe OHSS received 600 microg/kg meloxicam. Body weight, vascular permeability (VP), VEGF expression, ovary weight, and diameter were then compared. The efficacy of Cb2 and meloxicam for preventing OHSS. Comparison of the severe OHSS groups with the controls and mild OHSS group revealed significant increases in VEGF expression, VP, ovary weight, and diameter. The increase in VEGF expression was demonstrated to be dependent on human chorionic gonadotropin doses. However, low-dose Cb2 and meloxicam therapies were shown to be ineffective in decreasing VEGF expression and VP, ovary weight, and ovary diameter in severe OHSS. VEGF elevation played a critical part in OHSS pathogenesis, but the therapies administered failed to curb VEGF expression.
    Acta Obstetricia Et Gynecologica Scandinavica 05/2010; 89(5):692-9. · 1.85 Impact Factor
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    ABSTRACT: To investigate the association between high-risk human papillomavirus (HPV) types and soluble interleukin-2 receptor (sIL-2R) levels in female sex workers with a negative cervical smear result, and to determine the effectiveness of using sIL-2R levels to screen for high-risk strains of HPV. A negative cervical smear result and a blood sample were obtained from 68 women: 43 female sex workers and 25 women acting as controls. HPV DNA genotyping was performed and sIL-2R levels were assessed. Female sex workers had significantly higher sIL-2R levels than women in the control group (318.37+/-239.7 vs 114.4+/-56.5 U/mL, respectively P<0.001). In addition, female sex workers with high-risk strains of HPV had significantly higher sIL-2R levels than those who did not have high-risk strains of HPV (736.7+/-251.5 vs 250.5+/-156.1 U/mL, respectively; P=0.001). High sIL-2R levels may be useful in screening for high-risk strains of HPV in female sex workers who have a negative cervical smear result.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 05/2009; 106(3):210-2. · 1.41 Impact Factor
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    ABSTRACT: Pneumoperitoneum (Pp) induces an ischemia and reperfusion (I/R) injury as a result of released oxidative stress markers. Ischemic preconditioning (IP) is one of the used methods to reduce the harmful effects of Pp, which is a mechanism for reducing organ I/R injury by a brief period of organ ischemia. The aim of this study was to investigate the ideal time for IP in the laparoscopic model. Thirty-two rats were assigned into four groups: group 1 (control, n = 8) was subjected to a sham operation. Group 2 (5-minutes IP, n = 8) was subjected to 5 minutes of Pp with 15 mm Hg of pressure followed immediately by 5 minutes of deflation, and after that, 60 minutes of Pp with 15 mm Hg, followed by 60 minutes of deflation. Group 3 (10-minutes IP, n = 8) was subjected to 10 minutes of Pp and 10 minutes of deflation. Group 4 (Pp only, n = 8) was subjected to 60 minutes of Pp with 15 mm Hg of pressure, followed by 60 minutes of deflation. At the end of the experiment, plasma malondialdehyde (MDA) values, the oxidative stress marker, and plasma-reduced glutathione (GSH) levels, the marker showing antioxidant activity, were determined. Highest plasma MDA values were in group 4 (Pp only), followed by groups 2 and 3 and group 1 (P = 0.181). In addition, IP groups had almost the same values for MDA. Plasma GSH levels in the control group were significantly higher than those in the IP groups and the Pp-only group (P < 0.001). Similarly, as in MDA levels, no difference was found between plasma GSH levels of the IP 5-minutes and IP 10-minutes groups. Five minutes of the IP model may be as reliable as 10 minutes of the IP model. In that case, 5 minutes of IP can be more suitable in reducing I/R injury in laparoscopy.
    Journal of Laparoendoscopic & Advanced Surgical Techniques 03/2009; 19(2):141-7. · 1.07 Impact Factor
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    ABSTRACT: Congenital intracranial teratoma is a rare disease. A fetus with a congenital intracranial teratoma presenting with a hydrocephalus at 27 weeks' gestation is presented. Prenatal ultrasonography and fetal magnetic resonance imaging demonstrated a huge, heterogeneous intracranial mass including the infra- and supratentorial region and polyhydramnios. At 28 weeks' gestation, a cesarean section was performed to avoid divisive operation during delivery. The infant died after 10 min from respiratory failure. Histological examination revealed the diagnosis of immature teratoma. Early detection of congenital intracranial tumors is crucial. The prognosis is poor with death usually occurring shortly after birth.
    Fetal Diagnosis and Therapy 11/2008; 24(4):368-71. · 1.90 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the clinical relevance of dipper status in women with preeclampsia by comparing arterial stiffness index (SI) values, and dipper and nondipper status. A total of 60 pregnant women in their third trimester were enrolled in the study. SI values were measured using a digital photoplethysmographic method (Pulse Trace System, Micro Medical Ltd., Gillingham, Kent, UK). Twenty-four-hour ambulatory blood pressure was measured by a SpaceLabs 90217 oscillometric device (SpaceLabs Inc., Redmond, WA, USA). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were recorded. Those preeclamptic women whose mean nighttime blood pressure measurements were at least 10% lower compared with mean daytime measurements were classified as dipper status, and those with a decrease of less than 10% were classified as nondipper status. Seventeen women were preeclamptic with a dipper status, 13 women had nondipper status preeclampsia, and 30 women were normotensive. SI values were significantly higher in preeclamptic women compared with normotensive women (8.8+/-1.2 m/s vs. 5.9+/-0.8 m/s, P<0.001), but SI values of preeclamptic women with dipper status and preeclamptic women with nondipper status did not differ significantly from each other (P=0.485). There was no significant difference in SI values between the dipper and nondipper preeclamptic groups. These results indicate that dipper and nondipper measurements may not be suitable for clinical follow-up of preeclamptic women.
    Advances in Therapy 09/2008; 25(9):925-34. · 2.44 Impact Factor