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Publications (7)1.1 Total impact

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    ABSTRACT: In pathogenesis of obesity an important role is played by environmental, genetic and socio-cultural factors. In recent years major attention is paid to genetic factors in obesity. Many studies have proven that genetic factors are of poly-gene nature. This means that obesity is a sum of malfunctions of genes which are responsible for fat accumulation and metabolism and thus for maintaining the correct body weight. It is assumed that the structure and expression of genes which generate obesity may be affected by the nutrients supplied in the daily diet and that the gene-nutrient interactions may occur on various levels. Among the nutrients which influence the pathogenesis of obesity there are folic acid, B vitamins, calcium, vitamin D, antioxidant vitamins (vitamin A, E, C) and polyunsaturated fatty acids from the omega 3 group (mainly eicosapentaenoic and docosahexaenoic acids). It is suggested that shortages of these components may contribute to the excessive accumulation of body fat.
    Pediatria polska 06/2014;
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    ABSTRACT: Meningitis due to group A streptococci (GAS) is an uncommon manifestation of invasive streptococcal disease. Meningitis is associated with infectious foci of the upper respiratory tract, mainly otitis media. In children without acute infection Streptococcus pyogenes often colonize nosopharynx. The antibiotic of choice for the treatment of streptoccocal meningitis is penicillin. We present the case of a 5-year-old boy with GAS meningitis. His history presented recurrent otitis media. From throat and cerebrospinal fluid cultures was isolated the same GAS, which belongs to M1 serotype, the most prevalent in Poland. Treatment with cefotaxim and penicillin was given. The patient recovered, without any neurological deficiency.
    Pediatria polska 05/2014;
  • Beata Pyrzak, M Ruminska, K Popko, U Demkow
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    ABSTRACT: The prevalence of obesity in children and adolescents has been increasing worldwide. As in adults, childhood obesity is closely related to hypertension, dyslipidemia, type 2 diabetes, and insulin resistance (IR) syndrome. Moreover, obese children have been found to be at increased risk of becoming obese adults. Obese children and adolescents tend to develop serious medical and psychosocial complications and also are at greater risk morbidity and mortality in adulthood. The molecular basis of the pathogenesis of obesity-linked disorders has not been fully elucidated. Adipose tissue serves not only as an energy storage organ, but also as an endocrine organ. It releases many factors with autocrine, paracrine and endocrine functions. Adipokines such as leptin, resistin, tumor necrosis factor-α, interleukin-6, adipsin, visfatin, and adiponectin are biologically active molecules produced by adipose tissue. They play a role in energy homeostasis, and in glucose and lipid metabolism. Adiponectin level, unlike that of other adipocytokines, is decreased in obesity and increased after weight reduction. Adiponectin has been associated with both central obesity and increased visceral adipose tissue and it has anti-inflammatory, anti-atherogenic, and potent insulin-sensitizing (anti-diabetic) effects.
    European journal of medical research 11/2010; 15 Suppl 2:147-51. · 1.10 Impact Factor
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    ABSTRACT: IntroductionNon-HDL cholesterol (non-HDL) is recommended by NCEP ATP III (2005), its value correlates with level of apolipoprotein B and reflects the levels of all atherogenic lipid fraction. Non-HDL cholesterol is defined as the difference between the total cholesterol and the high-density lipoprotein cholesterol. Non-HDL cholesterol is better than LDL-Ch at predicting cardiovascular risk.
    Journal of Experimental Marine Biology and Ecology - J EXP MAR BIOL ECOL. 01/2010; 85(1):35-40.
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    ABSTRACT: The spread of overweight and obesity is alarming in the face of metabolic syndrome development and its consequences. As obesity becomes a social norm, a lack of adequate attention seems to be noticed. In the development of obesity special attention is focused on preschool and pubertal periods, as they are considered as critical in the development of obesity and its persistence into adulthood. We have analyzed anthropological parameters of 302 overweight and obese children, patients of the Department of Pediatrics and Endocrinology between 2004-2007. Children were at the age from 1.5 y to 18.25 y. Overweight was diagnosed when BMI > or =1 SDS, obesity when BMI > or =2 SDS. 77% of boys and 86% of girls were obese. The mean value of BMI, expressed as SDS BMI, was +4.3 SDS (girls) and +4.5 SDS (boys) in children under 6 yrs, +3.03 SDS (girls) and +2.95 SDS (boys) in children between 6-14 yrs, +3.95 SDS (girls) and +4.08 (boys) in children above 14 yrs. The youngest group (i.e. under 6 yrs), although comparatively most obese, was sparse: 7% of all girls and 5.6% of all boys. The oldest group (i.e.above 14 yrs) was plentiful (45.6% of all girls and 27.8% of all boys) and comparatively very obese. Data of parents' weight status were completed in 56% of cases: 31.2% of mothers and 41.5% of fathers were overweight, 33.3% of mothers and 50.8% of fathers were obese. These observations can suggest that overweight and obesity can be underestimated and/or ignored/ disregarded in preschool and pubertal children. It seems to be alarming as these two periods of life are critical in the development of obesity. Special attention should be applied in the field of prevention of obesity, especially in younger children, and early identification of overweight small children and/ or children at risk of obesity.
    Przegla̧d lekarski 02/2009; 66(1-2):45-8.
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    ABSTRACT: High dietary calcium intake has an impact on reduction of adipose tissue, as in prevention and treatment of obesity and metabolic syndrome (MS). The aim of the study was to evaluate the influence of dietary calcium on appearance MS in children and adolescents. The study included 150 patients in the age range of 7-18 years with obesity. In each child, the bioelectrical impedance analysis, waist circumference, blood pressure, lipids (enzymatic method), Oral Glucose Tolerance Test (OGTT) with marking of glucose, insulin blood levels (RIA method), and estimation of nutritional status had been made. The standard deviation score of body mass index (SDS BMI), waist to hip ratio (WHR), insulin resistance (HOMA-IR) was calculated. MS was recognized according Cook criteria. All patients had waist circumference greater than the 90 percentile. Boys had more often an abnormal lipids profile than girls. Both, high blood pressure and HOMA-IR >3 were found in over half of studied patients. The diet of many patients had too much fat and saccharose intaking. Only 20% of children consumed normal value of calcium. The observed intaking more than 20 mg of calcium per ideal body mass (i.b.m) per 24 hours had higher % FAT, SDS BMI, waist circumference, HOMA-IR, and insulin. MS was recognized more often in this group. Insufficient dietary calcium intake could have an effect on some parameters of metabolic syndrome.
    Pediatric endocrinology, diabetes, and metabolism. 02/2008; 14(4):231-5.
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    ABSTRACT: Prenatal and neonatal adrenal haemorrhage is being increasingly frequently reported. We present a group of 13 neonates with adrenal haemorrhage, hospitalised in the Department of Paediatrics and Endocrinology of Warsaw Medical University from 2003 to 2007. of this study was to analyse: the perinatal history, haemorrhage predisposing factors, its size, localization and progress estimated by ultrasonography, as well as clinical, biochemical and hormonal findings indicating adrenal insufficiency. the study group comprised 13 neonates hospitalised in the Department of Paediatrics and Endocrinology, Warsaw Medical University, from 2003 to 2007, due to adrenal haemorrhage diagnosed by ultrasonography in the first week of life. all neonates were born at term, there was a male predominance. Twelve neonates had risk factors such as: birth trauma, intrauterine infection, perinatal asphyxia. No risk factors were found only in 1 neonate. One neonate had bilateral adrenal haemorrhage, others were unilateral - predominantly right-sided. In the study group clinical presentation was asymptomatic in 3 neonates, 1 of the patients had anaemia, 9 persistent jaundice, 2 bluish discoloration of the scrotum. Only one patient with bilateral adrenal haemorrhage showed sings of adrenal insufficiency and supplementation with glyco- and mineralcorticoids was necessary. Complete resolution of adrenal haemorrhage was reported after an average time of 3.5 months of observation. 1. Adrenal haemorrhage in neonates rarely leads to development of adrenal insufficiency. 2. In neonates with bilateral adrenal haemorrhage an extended hormonal diagnosis is required. 3. All patients require a systematic clinical and sonographic follow-up. Unilateral haemorrhage should be differentiated from neuroblastoma. 4. Scrotal haematoma may be a symptom of adrenal haemorrhage.
    Medycyna wieku rozwojowego 01/2008; 12(1):457-62.