M D S Lokuhetty

Publications (3)2.32 Total impact

• Article: Gigantomastia in pregnancy with an accessory axillary mass masquerading as inflammatory carcinoma.

  M D S Lokuhetty, P A M Saparamadu, D M A Al-Sajee, R Al-Ajmi
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  ABSTRACT: Giagantomastia is a rare disorder known to occur in pregnancy, causing enlargement of the breasts greater than that of gravid enlargement. The histological features of gigantomastia are glandular hyperplasia and an increase of stromal tissue. Illustrated by one documented case, cytomorphology of gigantomastia was misdiagnosed as a phyllodes tumor. We document the cytomorphology of an axillary mass in a gravid woman of 24 years with gigantomastia. She presented in her first trimester with bilateral mastalgia and swelling, nonresponsive to antibiotics. Imaging excluded mass breast lesions and a pituitary prolactinoma. The breasts progressively enlarged, became warm, tender, and developed skin ulcerations and a peau d'orange appearance. Subsequently she developed a mass in her left axilla. On aspiration of the mass, some of the cytomorphological features were suspicious for a metastasis, which correlated well with her clinical features. Careful evaluation suggested cytomorphology to be compatible with benign accessory breast tissue with possible hormone related changes of pregnancy. Histology of the excised axillary mass confirmed this diagnosis. Thus, awareness of this rare condition and careful evaluation is mandatory to avoid misdiagnosis in a similar clinical context.
  Diagnostic Cytopathology 02/2011; 39(2):141-3. · 1.16 Impact Factor
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  Available from: sljol.info

  Article: Trans rectal ultra sound guided prostate biopsies: a single centre experience in Sri Lanka.

  M D S Lokuhetty, H D Wijesinghe, D T Abeysuriya, U C Samarasinghe, N D Perera
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  ABSTRACT: Trans rectal ultrasound guided prostate biopsy (TRUS) was introduced to Sri Lanka in 2002. 1. To study clinicopathological features of males subjected to TRUS biopsy 2. To compare estimation of tumour burden by two methods in carcinoma prostate (CaP). 749 symptomatic males subjected to TRUS biopsy over 64 months at a single centre. Information was retrieved from case records. Tumour burden in CaP was calculated as: 1. Calculated tumour burden (CTB)--total percentage tumour in each core/total number of cores 2. Percentage positive biopsy cores (PPBC)--number of positive cores/total number of cores X 100. SPSS 15.0, student's t test and Spearman's rank correlation coefficients were used for statistical analysis. 35.2% had CaP, microacinar in type. 34.88% were poorly differentiated. CaP was frequent among older patients (P<0.00001). The prostate volume in CaP was significantly lower than in the benign group (P<0.05). Prostate specific antigen (PSA) level was significantly higher in CaP (P<0.00001). A 99.6% sensitivity and 4.7% specificity was observed at PSA of 4 ng/ml for detecting CaP. Specificity was 98% at 25.5 ng/ml, with a sensitivity of 44.4%. CTB and PPBC had similar correlations with biochemical/histological parameters of CaP and were strongly correlated (0.786). Males with CaP were older, had higher PSA levels and smaller prostates. A cut off level of PSA >4 ng/ml could be used for directing symptomatic patients for TRUS biopsy to detect CaP, keeping in mind that specificity is 98% only at 25.5 ng/ml. Both CTB and PPBC could be used to calculate tumour burden in TRUS with CaP.
  Ceylon Medical Journal 04/2009; 54(1):6-9.
• Article: Invasive micropapillary carcinoma of the breast: Cytomorphology of a metastatic deposit.

  M D S Lokuhetty, N Fernandopulle
  Diagnostic Cytopathology 02/2007; 35(1):65-6. · 1.16 Impact Factor