Kyoko Yamamoto

Publications (3)6.21 Total impact

• Article: Case of Mycoplasma pneumoniae infection with maculopapular-type eruptions due to acetaminophen.

  Naoko Takeo, Yutaka Hatano, Kyoko Yamamoto, Seiji Shiota, Sakuhei Fujiwara
  The Journal of Dermatology 01/2013; · 1.49 Impact Factor
• Article: A diagnosis of depression should be considered in patients with multiple physical symptoms in primary care clinics.

  Kyoko Yamamoto, Seiji Shiota, Shigeki Ohno, Akiko Kuroda, Aoi Yoshiiwa, Koh Abe, Kazunari Murakami, Toshio Fujioka
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  ABSTRACT: Although the vast majority of depressed patients visit primary health care clinics, they often remain undiagnosed and untreated. Therefore, early detection in primary care settings is important. There is a high correlation between number of physical symptoms and the presence of depression, yet little has been reported regarding this relationship in Japanese primary care clinics. We examined number of physical symptoms and depression in a department of general medicine of a Japanese hospital. We included patients with unexplained symptoms after multiple tests to rule out organic diseases. Twenty-one common symptoms were assessed using a symptom checklist. Depression was diagnosed using the Patient Health Questionnaire-9, a self-administered questionnaire designed to diagnose depression. Among 386 patients, 105 (27.2%) (average age: 49.7 ± 20.9 years, 28 men and 77 women) met the criteria for depression. Among the 21 symptoms, 14 were significantly more frequent in patients with depression than in those without depression. When patients had neither general fatigue, nor sleep disturbance nor appetite loss, none met the criteria for depression. Number of symptoms was significantly higher in patients with compared with those without depression. The prevalence of depression increased with number of symptoms: 2% (2/100) for 0 or 1 symptom, 42.4% (42/99) for four to five symptoms and 68.7% (22/32) for more than nine symptoms. Japanese primary care physicians can often rule out depression when patients have neither general fatigue, nor sleep disturbance nor appetite loss. A diagnosis of depression should be considered in patients who report multiple physical symptoms.
  The Tohoku Journal of Experimental Medicine 01/2013; 229(4):279-85. · 1.24 Impact Factor
• Article: The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan.

  Seiji Shiota, Kazunari Murakami, Aoi Yoshiiwa, Kyoko Yamamoto, Shigeki Ohno, Akiko Kuroda, Kazuhiro Mizukami, Katsuhiro Hanada, Tadayoshi Okimoto, Masaaki Kodama, Kou Abe, Yoshio Yamaoka, Toshio Fujioka
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  ABSTRACT: Although two studies have indicated a possible link between Alzheimer's disease (AD) and Helicobacter pylori (H. pylori) infection, these were reported from Europe, where the prevalence of H. pylori infection is not very high. In this study, the prevalence of H. pylori infection was examined in AD patients in Japan, where there is a high prevalence of H. pylori. Consecutive patients referred to the Memory and Dementia Outpatient Clinic from August 2002 to March 2009 were studied. H. pylori infection status was determined by measuring urinary levels of anti-H. pylori antibody (RAPIRUN(®)). Multiple stepwise logistic regression analyses were used to examine the associations of AD with the main predictor variables. Of the 917 patients who visited the clinic, 385 were diagnosed as having AD. Ninety-seven patients did not have dementia and were considered controls. On univariate analysis, average age and the proportion of males were significantly higher in AD patients than in controls. There was no difference in the prevalence of H. pylori infection between patients with AD and controls (62.0% vs. 59.7%, p = 0.67, crude odds ratio (OR), 1.10). Multiple logistic regression analysis showed that older age and male sex, but not H. pylori status, were significantly associated with AD (p < 0.001, p = 0.01, p = 0.83, respectively). The prevalence of H. pylori infection did not differ between AD patients and controls among Japanese subjects. The high prevalence of H. pylori in controls may contribute to the discrepancy with previous reports.
  Journal of Neurology 02/2011; 258(8):1460-3. · 3.47 Impact Factor