Kyu Seop Kim

Catholic University of Korea, Sŏul, Seoul, South Korea

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Publications (31)117.38 Total impact

  • Seung Hoon Oh · Kyu Seop Kim · Won Ki Lee
    Clinical and Experimental Optometry 05/2015; DOI:10.1111/cxo.12273 · 1.26 Impact Factor
  • Donghyun Jee · Kyu Seop Kim · Won Ki Lee · Wungjae Kim · Sohee Jeon
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    ABSTRACT: Abstract Purpose: To investigate the clinical characteristics and treatment results of adult patients with ocular toxocariasis. Methods: A total of 54 consecutive patients who were clinically and serologically diagnosed with ocular toxocariasis were retrospectively reviewed. Results: Among patients, 66.7 and 77.3% showed increases in eosinophil cationic protein (ECP) and total Ig E in serum, respectively. Four eyes (7.2%) initially presented as neuroretinitis with subsequent motile retinal lesion. The recurrence rates in the combination treatment group with albendazole and corticosteroids were significantly lower than those in the steroid-alone group during the mean follow-up of 27.6 months (p = 0.001). Conclusions: The adjunctive test of serum total IgE level may be helpful for the diagnosis of ocular toxocariasis. Ocular toxocariasis should be considered in the differential diagnosis of unilateral neuroretinitis with subsequent motile retinal lesion. Combined treatment with albendazole and corticosteroids appeared to be effective for reducing the recurrence of intraocular inflammation.
    Ocular Immunology and Inflammation 01/2015; DOI:10.3109/09273948.2014.994783 · 1.44 Impact Factor
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    ABSTRACT: Aplastic anemia (AA) is a rare disease with few reports on its ophthalmic manifestations. The ocular findings are described in a retrospective consecutive series of 719 AA Korean patients followed at the Hematology Clinic of The Catholic University of Korea. Out of a total of 719 patients, 269 patients had eye examinations, 156 patients had retinal evaluation, and 37 (23.7%) had retinal findings. These 37 patients had unilateral retinal hemorrhage in seven and bilateral retinal hemorrhage in 30 with mean hemoglobin of 6.6 g/dL (range 2.7-12.6 g/dL) and platelet counts of 18.8×10(9)/L (range 4-157×10(9)/L); central retinal vein occlusion-like picture occurred in nine patients and these had similar rheology to the rest of the subjects; optic disc edema, cotton-wool spots, macular edema, and dry eyes occurred in two, three, five, and three patients, respectively. In this Korean series of 141 subjects with AA, systemic bleeding occurred in 24.8% of subjects, retinal hemorrhage in 37% of subjects, and any bleeding site (eye or elsewhere) occurred in 47.5% of subjects with AA. A literature review (1958-2010) of 200 AA cases revealed retinal hemorrhages in 56%, subhyaloid or vitreous hemorrhage in 9%, peripheral retinal vasculopathy in 5.5%, and cotton-wool spots, Sjögren's syndrome, or optic disc edema in 4% each. The prevalence of retinopathy among series of AA patients varied from 20% to 28.3%, which is consistent with the Korean series of 24.8%. Management of AA patients needs to involve multiple specialties, including hematologists, ophthalmologists, and infectious disease specialists.
    Clinical ophthalmology (Auckland, N.Z.) 04/2014; 8:777-787. DOI:10.2147/OPTH.S62163
  • The Lancet Infectious Diseases 11/2013; 13(11):994. DOI:10.1016/S1473-3099(13)70198-1 · 19.45 Impact Factor
  • Kyu Seop Kim · Won Ki Lee · Seung Bum Lee
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    ABSTRACT: To evaluate the efficacy of half-dose photodynamic therapy (PDT) targeting only the focal leakage point on fluorescein angiography for acute central serous chorioretinopathy (CSC). Non-randomized, retrospective, comparative, interventional case series. Ten consecutive eyes with acute CSC underwent PDT and later 11 eyes were observed without treatment. Main outcome measures included achievement of complete resolution of subretinal fluid (SRF), change in best-corrected visual acuity, and central retinal sensitivity. Complete resolution of SRF was achieved in 80.0% and 18.2% of eyes in the PDT group and the observation group at 1 month (P = .009), 100% and 27.3% at 3 months (P = .001), and 90% and 63.6% at 12 months (P = .311), respectively. At 12 months, three eyes (27%) in the observation group had a persistent lesion, while no such lesions were observed in the eyes in the PDT group. One eye in each group showed recurrence during the 12-month follow-up period. Visual acuity improved significantly in both groups at each time point, and the differences between groups were not significant. The mean central retinal sensitivity at 3 months was significantly higher in the PDT group compared with the observation group. Fluorescein angiography-guided half-dose PDT appears to facilitate faster resolution of SRF in acute CSC without however convincing long-term anatomical and functional benefits. This protocol may further enhance the safety of PDT.
    American Journal of Ophthalmology 10/2013; 157(2). DOI:10.1016/j.ajo.2013.10.013 · 4.02 Impact Factor
  • Yuli Park · Kyu Seop Kim · Young-Hoon Park
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    ABSTRACT: Abstract Purpose: To evaluate the incidence, causative organism, clinical features, and visual outcome of acute endophthalmitis following intravitreal injection and to report the clinical outcome of patients receiving preinjection antibiotics for the prevention of endophthalmitis. Methods: For all intravitreal triamcinolone acetonide, bevacizumab, ranibizumab, and C3F8 gas injections performed in our outpatient clinic between June 2008 and November 2012, the number of injections, indications, types of administered drugs, and methods of injection were investigated. A retrospective chart review was performed comparing patients with self-administration of antibiotic eye drops for 3 days before injection (n=8649 injections), and patients those who received no pretreatment with antibiotics (n=8683 injections). Cases of suspected endophthalmitis after intravitreal injection during this period were identified and reviewed retrospectively. Results: The total number of intravitreal injections was 17,332. The incidence of acute endophthalmitis for all intravitreal injections was 0.000% (0/849) for triamcinolone acetonide, 0.022% (2/9,125) for bevacizumab, 0.000% (0/7,061) for ranibizumab, and 0.337% (1/297) for C3F8 gas injections. The overall rate of intravitreal injection-related endophthalmitis with the use of topical antibiotics given 3 days before injection was no less statistically significant compared with that of no antibiotics. Staphylococcus species was confirmed in the bacterial culture of one eye with acute endophthalmitis. After early vitrectomy and intravitreal antibiotic injection, one eye maintained vision, but the other eye developed phthisis. Conclusions: All 3 endophthalmitis patients had not taken prophylactic preinjection topical antibiotics, but the difference in the rates of endophthalmitis between those who received a multiday course of preinjection antibiotics and those who did not was not statistically significant. The rate of endophthalmitis after intravitreal injection using aseptic techniques in the clinical practice setting is similar with or without the use of preinjection antibiotics. Preinjection antibiotic use confers no additional benefit in the treatment of endophthalmitis compared to without preinjection antibiotics.
    Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics 09/2013; DOI:10.1089/jop.2013.0052 · 1.42 Impact Factor
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    The Korean Journal of Internal Medicine 09/2013; 28(5):619-21. DOI:10.3904/kjim.2013.28.5.619
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    ABSTRACT: Aortoenteric fistula (AEF) developed after treatment for an abdominal aortic aneurysm (AAA) is a rare but usually fatal complication. We report a rare case of AEF bleeding after endovascular stent grafting for AAA which was managed angiographically. An 81-year-old man presented with hematochezia and acute abdominal pain for 1 day ago. Four years ago, an aortic stent was implanted in the infrarenal aorta for AAA. Endoscopies were performed to evaluate the hematochezia. Evidence of gastrointestinal bleeding was observed, but a clear bleeding point was not detected on upper endoscopy and colonoscopy. Contrast-enhanced computed tomography performed subsequently showed that the bleeding point was located in the fourth portion of the duodenum as an AEF caused by an inflammatory process in the stent-graft. Intra-arterial angiography showed a massive contrast leakage into the bowel via a small fistula from around the aortic stent graft site. Embolization was successfully performed by injecting a mixture of glue and lipiodol into the AEF tract. The patient was discharged with no evidence of gastrointestinal bleeding after the embolization. (Korean J Gastroenterol 2013;61:230-233).
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 04/2013; 61(4):230-3. DOI:10.4166/kjg.2013.61.4.230
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    ABSTRACT: Abstract Purpose: To determine whether the frequencies of specific killer cell immunoglobulin-like receptors (KIR) genotypes are associated with the incidence of uveitis in ankylosing spondylitis (AS) and Behçet disease (BD). Methods: The authors analyzed the frequency of 16 KIR genes in Koreans with either AS (110 patients, all HLA-B27-positive) or BD (86 patients), using polymerase chain reaction sequence-specific oligonucleotide probing. Results: The frequency of the inhibitory receptor KIR3DL1 was lower in AS patients affected by uveitis than that in the general population (p < 0.05). The frequency of the KIR3DL1(-)/2DS3(-) was significantly higher in AS patients with uveitis (odds ratio = 9.306, p = 0.007). Conclusions: The study suggests that KIR3DL1 might associate with the resistance to AS-associated uveitis by influencing natural killer cell activity.
    Ocular immunology and inflammation 04/2013; 21(2):135-143. DOI:10.3109/09273948.2012.754905 · 1.44 Impact Factor
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    Sohee Jeon · Won Ki Lee · Kyu Seop Kim
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    ABSTRACT: PURPOSE:: The purpose of this study was to evaluate the 3-year outcome of adjusted retreatment with photodynamic therapy (PDT), thermal laser, and intravitreal bevacizumab (IVB) after their initial PDT/IVB combination therapy for polypoidal choroidal vasculopathy. METHODS:: Data on 40 treatment-naive eyes of 38 patients with polypoidal choroidal vasculopathy were reviewed, all initially subjected to whole-lesion PDT/IVB. When retreating persistent or recurrent exudation, the aim was to reduce PDT frequency and spot size, avoiding whole-lesion PDT when feasible. Distinct polyps were thus selectively targeted using PDT and/or laser, routinely combined with IVB. If polyps were absent or questionable, IVB monotherapy was given. RESULTS:: At Year 3, the mean logarithm of minimal angle of resolution best-corrected visual acuity improved from 0.67 (Snellen equivalent of 20/93) to 0.55 (Snellen equivalent of 20/70), but the improvement was not statistically significant (P = 0.076). Best-corrected visual acuity remained stable or improved in 33 eyes (82.5%). The mean number of combination treatments and total IVB courses were 1.66 (range, 1-4) and 5.92 (range, 1-18), respectively. Five eyes (12.5%) required focal laser treatment for extrafoveal polypoidal lesions during follow-up. CONCLUSION:: Compared with reported 3-year outcomes of PDT as monotherapy for polypoidal choroidal vasculopathy, this approach proved favorable in improving or stabilizing visual acuity and reducing cumulative PDT exposure.
    Retina (Philadelphia, Pa.) 03/2013; 33(6). DOI:10.1097/IAE.0b013e318276e096 · 3.18 Impact Factor
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    ABSTRACT: The rate of diagnosis of gastric adenoma has increased because esophagogastroduodenoscopy is being performed at an increasingly greater frequency. However, there are no treatment guidelines for low-grade dysplasia (LGD). To determine the appropriate treatment for LGD, we evaluated the risk factors associated with the categorical upgrade from LGD to high grade dysplasia (HGD)/early gastric cancer (EGC) and the risk factors for recurrence after endoscopic treatment. We compared the complication rates, recurrence rates, and remnant lesions in 196 and 56 patients treated with endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR), respectively, by histologically confi rming low-grade gastric epithelial dysplasia. The en bloc resection rate was significantly lower in the EMR group (31.1%) compared with the ESD group (75.0%) (p<0.001). However, no significant difference was observed in the prevalence of remnant lesions or recurrence rate (p=0.911) of gastric adenoma. The progression of LGD to HGD or EGC caused an increase in the incidence of tumor lesions >1 cm with surface redness and depressions. For the treatment of LGD, EMR resulted in a higher incidence of uncertain resection margins and a lower en bloc resection rate than ESD. However, there was no signifi cant difference in recurrence rate.
    Gut and liver 10/2012; 6(4):446-51. DOI:10.5009/gnl.2012.6.4.446 · 1.49 Impact Factor
  • Mee Yon Lee · Kyu Seop Kim · Won Ki Lee
    American Journal of Ophthalmology 05/2012; 153(5):1004-5; author reply 1005. DOI:10.1016/j.ajo.2012.01.028 · 4.02 Impact Factor
  • Won Ki Lee · Kyu Seop Kim · Wungjae Kim · Seung Bum Lee · Sohee Jeon
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    ABSTRACT: To investigate the responses to photodynamic therapy (PDT) in patients with polypoidal choroidal vasculopathy (PCV) that show large aneurysmal dilation with internal angio-architecture consisting of diverse patterns of curvilinear vessels and polyps resembling grape clusters. Retrospective, interventional case series. Twenty-two eyes of 22 patients were included. All patients initially received PDT monotreatment. The main outcome measures were the rates of complete polyp regression on indocyanine green angiography and initial favorable responses observed clinically. Also, the rates of recurrent exudative changes were evaluated at the 2-year follow-up. We focused on changes in the vascular features and their clinical association. Complete regression of polypoidal lesions was observed in 21 eyes (95%) after a mean of 1.7 PDTs. However, favorable clinical responses were achieved in only 9 eyes (41%), and 6 of them had recurrent exudation. Main vessels, previously consisting of the polypoidal lesion frame, persisted. Additionally, aberrant vessels with a thin radiating or tortuous configuration were observed in the area where large aneurysmal dilation was present. Leakage from this vascular complex or an expanded vascular complex was observed in a total of 14 eyes (64%) during the 2-year follow-up, contributing to persistent (8 eyes) or recurrent (6 eyes) exudation. This seemed to represent secondary choroidal neovascularization (CNV). In another 4 eyes (18%), fibrous changes developed immediately after PDT. Polyps recurred in 8 eyes (38%). This PCV pattern frequently evolved into typical CNV after PDT, resulting in persistent or recurrent exudation despite the disappearance of polypoidal structures.
    American Journal of Ophthalmology 04/2012; 154(2):355-365.e1. DOI:10.1016/j.ajo.2012.02.019 · 4.02 Impact Factor
  • Kyu Seop Kim · Seung Bum Lee · Won Ki Lee
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    ABSTRACT: To compare clinical outcomes after vitrectomy and internal limiting membrane (ILM) peeling, with and without gas tamponade, for the treatment of myopic foveoschisis. Retrospective, comparative, interventional case series. In this retrospective clinical study, 17 eyes of 17 consecutive patients underwent vitrectomy and ILM peeling for treatment of myopic foveoschisis. Eyes were divided into 2 groups, those with gas tamponade (n = 9) and those without (n = 8). Gas tamponade was chosen according to the period and surgeon's discretion. The changes of foveal anatomy on preoperative optical coherence tomography (OCT) were not considered in the decision. Main outcome measures were the rate of resolution of myopic foveoschisis measured by OCT, the time interval until resolution of myopic foveoschisis, central foveal thickness, and best-corrected visual acuity (BCVA). After surgery, OCT showed a resolution of myopic foveoschisis in 8 eyes (88.9%) in the gas-treated group and in 6 eyes (75.0%) in the no-gas group. This difference between the groups was statistically insignificant (P = .576). The mean period until the resolution of myopic foveoschisis was 2.25 months in the gas-treated group and 4.50 months in the no-gas group (P = .011). The mean BCVA improved significantly in both the gas-treated and no-gas groups (P = .011 and P = .017, respectively). Vitrectomy and ILM peeling without gas tamponade appears to be as effective in the treatment of myopic foveoschisis as vitrectomy with gas tamponade. However, eyes treated with gas tamponade showed more rapid resolution of myopic foveoschisis.
    American Journal of Ophthalmology 02/2012; 153(2):320-326.e1. DOI:10.1016/j.ajo.2011.07.007 · 4.02 Impact Factor
  • Kyu Seop Kim · Won Ki Lee
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    ABSTRACT: To report on a patient with bilateral macular holes who developed circular retinal pigment epithelial atrophy at the fovea after macular hole surgery using indocyanine green in both eyes.
    Retinal Cases & Brief Reports 01/2012; 6(3):278-9. DOI:10.1097/ICB.0b013e318228e33e
  • Seung Bum Lee · Kyu Seop Kim · Won Ki Lee
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    ABSTRACT: We report a case of a full-thickness macular hole treated in a female adult with bilateral retinal capillary hemangiomas.
    Journal of the Korean Ophthalmological Society 01/2012; 53(8):1177. DOI:10.3341/jkos.2012.53.8.1177
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    ABSTRACT: Anaplastic carcinoma of the pancreas is an extremely rare but aggressive, rapidly progressive tumor. It often presents with invasion of adjacent organs and distant metastases. Most cases are inoperable and confirmed by autopsy. A correct diagnosis of stomach invasion by anaplastic carcinoma of the pancreas is important due to the risk of bleeding, perforation by rapid tumor growth, and a poor prognosis. However, an accurate diagnosis is difficult as a result of the various clinical presentations, symptoms, and radiological findings. We herein report a case of anaplastic carcinoma of the pancreas in a 78-year-old woman who presented with stomach invasion mimicking a gastrointestinal stromal tumor.
    01/2012; 83(2):226. DOI:10.3904/kjm.2012.83.2.226
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    ABSTRACT: We report a rare case of cervical cancer with duodenal obstruction accompanied by obstructive symptoms, which was treated using duodenal stenting. A 48-year-old woman was diagnosed with stage IV cervical cancer (according to the International Federation of Gynecology and Obstetrics staging system), which had invaded the vagina, the uterine body, and the external iliac and common iliac lymph nodes. Endoscopy showed an encircling mass with erythematous mucosa and luminal narrowing in the second and third portions of the duodenum, which prevented the endoscope from advancing. We placed an uncovered stent in the duodenum, which ameliorated abdominal discomfort, nausea, and vomiting, and simultaneously performed a biopsy. Endoscopic stent insertion appears to be the most effective treatment for duodenal obstruction in patients with advanced cancer.
    01/2012; 12(2):128. DOI:10.7704/kjhugr.2012.12.2.128
  • Young-Hoon Park · Kyu Seop Kim
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    ABSTRACT: A 32-year-old man presented with vision loss in the left eye. One week earlier, while under local anesthesia, he had had an autologous fat injection into his forehead to correct frown lines. During the injection, he felt a sudden, severe periocular pain and had complete vision loss in his left eye.
    New England Journal of Medicine 12/2011; 365(23):2220. DOI:10.1056/NEJMicm1100804 · 54.42 Impact Factor
  • Kyu Seop Kim · Won Ki Lee
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    ABSTRACT: To report the efficacy of intravitreal bevacizumab for either recurrent or persistent serous changes originating from a persistent branching vascular network or secondary choroidal neovascularization after photodynamic therapy for polypoidal choroidal vasculopathy, despite regression of polypoidal lesions. Twenty eyes of 20 patients with at least 12 months of regular follow-up were retrospectively reviewed. Intravitreal bevacizumab was administered on an as-needed basis, guided by optical coherence tomography (OCT), after the first injection. Seventeen (85%) of 20 eyes showed resolution of macular fluid after a mean of 1.9 (range 1-3) consecutive injections; however, 15 (88%) of them had relapsing episodes of fluid collection. The mean number of injections needed was 4.2 (range 1-6) over a period of 12 months. At 12 months, 10 eyes (50%) had no fluid accumulation on OCT, while 10 eyes (50%) had some residual fluid. The mean central foveal thickness improved significantly from 280 ± 37 to 226 ± 62 μm (P = 0.002). Visual acuity was maintained or improved in 16 eyes (80%). Intravitreal bevacizumab appears to be effective in resolving intraretinal and subretinal fluid originating from these lesions. However, the favorable effect was maintained for only a limited period of time and required repeated injections.
    Japanese Journal of Ophthalmology 06/2011; 55(4):370-7. DOI:10.1007/s10384-011-0045-z · 1.80 Impact Factor

Publication Stats

102 Citations
117.38 Total Impact Points

Institutions

  • 2009–2015
    • Catholic University of Korea
      • Department of Ophthalmology
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Chungnam National University Hospital
      Sŏul, Seoul, South Korea
  • 2008–2011
    • Chungnam National University
      • Department of Internal Medicine
      Seongnam, Gyeonggi, South Korea